Journal of Environmental Exposure Assessment,
Год журнала:
2025,
Номер
4(2)
Опубликована: Апрель 11, 2025
Chemical
composition
plays
a
crucial
role
in
the
adverse
health
effects
of
fine
particulate
matter
(PM2.5),
yet
traditional
methods
fail
to
comprehensively
identify
toxic
components.
In
this
study,
we
developed
non-targeted
approach
using
gas
chromatography
and
high-resolution
mass
spectrometry,
obtained
database
2,138
organic
components
from
PM2.5
samples
collected
urban
Beijing
between
2016
2018.
Meanwhile,
exposed
extracts
human
lung
epithelial
cell
line
measured
intracellular
reactive
oxygen
species
(ROS)
extracellular
cytokines
as
indicators
cellular
response.
A
combination
single
pollutant
model,
partial
least
squares
regression,
Bayesian
kernel
machine
regression
was
applied
filtered
165
robust
database.
Beyond
110
classic
polycyclic
aromatic
compounds
(PACs),
also
identified
14
anhydrides
21
nitrated
contributors
toxicity.
Molecular
features
such
unsaturation
volatility
were
found
be
most
significant
factors
influencing
effects.
Source
apportionment
analysis
demonstrated
distinct
seasonal
patterns
toxicological
impacts.
During
heating
season,
biomass
burning
emerged
predominant
pollution
source,
with
its
two-fold
intensity
elevation
correlating
2.0%
increase
tumor
necrosis
factor
(TNF)-α,
accompanied
by
6.0%
7.6%
decreases
vascular
endothelial
growth
(VEGF)
interleukin
(IL)-8,
respectively.
contrast,
non-heating
season
observations
revealed
vehicular
emission
principal
contributor,
inducing
pronounced
11.0%
ROS
levels.
This
study
introduces
an
effect-oriented
for
screening
ambient
PM2.5,
offering
valuable
insights
support
formulation
public
protection
strategies.
Journal of Geophysical Research Atmospheres,
Год журнала:
2025,
Номер
130(4)
Опубликована: Фев. 19, 2025
Abstract
PM
2.5
‐bound
antimony
(Sb)
may
threaten
human
health
and
sustainable
development,
necessitating
accurate
source
identification
for
its
effective
control.
This
study
pioneered
the
application
of
Sb
isotope
signatures
to
trace
sources,
presenting
first
isotopic
fingerprints
in
urban
.
We
selected
two
mega‐cities
with
contrasting
profiles:
more
developed
Wuhan
central
less
Guiyang
southwest
China.
Urban
both
cities
exhibited
an
ε
123
value
1.84
±
0.79‱,
a
distinct
seasonal
pattern,
that
is,
heavier
isotopes
spring/winter
lighter
summer/autumn.
Isotopic
apportionment
revealed
waste
incineration
as
predominant
anthropogenic
cites
at
34.0–39.1%,
despite
their
massive
economic
industrial
differences.
Brake
wear
emerged
second
major
source,
especially
Wuhan,
where
vehicle
ownership
is
greater,
accounting
21.2%.
Complementary
analyses
using
enrichment
factor,
elemental
ratios,
positive
matrix
factorization
modeling,
backward
trajectory
analysis
corroborated
findings.
offers
novel
approach
identify
unveiling
brake
contributors
from
new
perspective.
Journal of Environmental Exposure Assessment,
Год журнала:
2025,
Номер
4(2)
Опубликована: Апрель 11, 2025
Chemical
composition
plays
a
crucial
role
in
the
adverse
health
effects
of
fine
particulate
matter
(PM2.5),
yet
traditional
methods
fail
to
comprehensively
identify
toxic
components.
In
this
study,
we
developed
non-targeted
approach
using
gas
chromatography
and
high-resolution
mass
spectrometry,
obtained
database
2,138
organic
components
from
PM2.5
samples
collected
urban
Beijing
between
2016
2018.
Meanwhile,
exposed
extracts
human
lung
epithelial
cell
line
measured
intracellular
reactive
oxygen
species
(ROS)
extracellular
cytokines
as
indicators
cellular
response.
A
combination
single
pollutant
model,
partial
least
squares
regression,
Bayesian
kernel
machine
regression
was
applied
filtered
165
robust
database.
Beyond
110
classic
polycyclic
aromatic
compounds
(PACs),
also
identified
14
anhydrides
21
nitrated
contributors
toxicity.
Molecular
features
such
unsaturation
volatility
were
found
be
most
significant
factors
influencing
effects.
Source
apportionment
analysis
demonstrated
distinct
seasonal
patterns
toxicological
impacts.
During
heating
season,
biomass
burning
emerged
predominant
pollution
source,
with
its
two-fold
intensity
elevation
correlating
2.0%
increase
tumor
necrosis
factor
(TNF)-α,
accompanied
by
6.0%
7.6%
decreases
vascular
endothelial
growth
(VEGF)
interleukin
(IL)-8,
respectively.
contrast,
non-heating
season
observations
revealed
vehicular
emission
principal
contributor,
inducing
pronounced
11.0%
ROS
levels.
This
study
introduces
an
effect-oriented
for
screening
ambient
PM2.5,
offering
valuable
insights
support
formulation
public
protection
strategies.
