Arsenic and Chromium Induced Toxicity on Zebrafish Kidney: Mixture Effects on Oxidative Stress and Involvement of Nrf2‐Keap1‐ARE, DNA Repair, and Intrinsic Apoptotic Pathways DOI

Sreejata Kamila,

Koushik Kumar Dey,

Ansuman Chattopadhyay

и другие.

Journal of Applied Toxicology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

ABSTRACT In polluted water, cooccurrences of two carcinogens, arsenic (As) and chromium (Cr), are extensively reported. Individual effects these heavy metals have been reported in kidney fishes, but underlying molecular mechanisms not well established. There is no report on combined exposure As Cr kidney. Thus, the present study investigated compared individual zebrafish ( Danio rerio ) treating at their environmentally relevant concentrations for 15, 30, 60 days. Increased ROS levels, lipid peroxidation, GSH level, decreased catalase activity implied oxidative stress treated Damage histoarchitecture groups was also noticed. The current involved gene expression Nrf2, an important transcription factor cellular responses along with its negative regulator Keap1 downstream antioxidant genes nqo1 ho1 . Results indicated activation Nrf2‐Keap1 pathway after exposure. Expression pattern ogg1 , apex1 polb creb1 revealed inhibition base excision repair treatments. mRNA tumor suppressor p53 brca2 altered. Expressional alteration bax bcl2 caspase9 caspase 3 apoptosis (intrinsic pathway) induction, which maximum group. Inhibition DNA induction that activated system enough to overcome damage caused by Cr. Overall, this additive chronic focusing responses.

Язык: Английский

Ferulic Acid Ameliorates Chromium-Induced Nephrotoxicity: Modulation of PERK/eIF2α/ATF4/CHOP, Nrf2, and Inflammatory Signaling DOI
Samyah Alanazi, Samir A. Salama,

Musaad M Althobaiti

и другие.

Biological Trace Element Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский

Процитировано

0
Chronic Exposure to Lead Causes Neurotoxicity by Generating Oxidative Stress and Inducing DNA Damages in Zebrafish Brain: Involvement of Nrf2-Keap1 Regulation and DNA Repair Pathways DOI

Koushik Kumar Dey,

Sreejata Kamila,

Tanmoy Das

и другие.

Biological Trace Element Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

0
Arsenic and Chromium Induced Toxicity on Zebrafish Kidney: Mixture Effects on Oxidative Stress and Involvement of Nrf2‐Keap1‐ARE, DNA Repair, and Intrinsic Apoptotic Pathways DOI

Sreejata Kamila,

Koushik Kumar Dey,

Ansuman Chattopadhyay

и другие.

Journal of Applied Toxicology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

ABSTRACT In polluted water, cooccurrences of two carcinogens, arsenic (As) and chromium (Cr), are extensively reported. Individual effects these heavy metals have been reported in kidney fishes, but underlying molecular mechanisms not well established. There is no report on combined exposure As Cr kidney. Thus, the present study investigated compared individual zebrafish ( Danio rerio ) treating at their environmentally relevant concentrations for 15, 30, 60 days. Increased ROS levels, lipid peroxidation, GSH level, decreased catalase activity implied oxidative stress treated Damage histoarchitecture groups was also noticed. The current involved gene expression Nrf2, an important transcription factor cellular responses along with its negative regulator Keap1 downstream antioxidant genes nqo1 ho1 . Results indicated activation Nrf2‐Keap1 pathway after exposure. Expression pattern ogg1 , apex1 polb creb1 revealed inhibition base excision repair treatments. mRNA tumor suppressor p53 brca2 altered. Expressional alteration bax bcl2 caspase9 caspase 3 apoptosis (intrinsic pathway) induction, which maximum group. Inhibition DNA induction that activated system enough to overcome damage caused by Cr. Overall, this additive chronic focusing responses.

Язык: Английский

Процитировано

2