Effect of Antioxidants on the Gut Microbiome Profile and Brain Functions: A Review of Randomized Controlled Trial Studies

Foods, Год журнала: 2025, Номер 14(2), С. 176 - 176

Опубликована: Янв. 8, 2025

Antioxidants are widely recognized for their potential health benefits, including impact on cognitive function and gut microbiome modulation. Understanding these effects is essential exploring broader clinical applications. This review aims to evaluate the of antioxidants function, with a focus findings from randomized controlled trials (RCTs). The studies involved human participants across range age groups, interventions encompassing natural antioxidant sources, such as berries, well specific vitamins. An extensive search PubMed, SCOPUS, Web Science databases identified six relevant RCTs, each evaluated bias. These focused variety antioxidant-rich products, both naturally derived sources supplemental forms. Antioxidants, vitamins C, B2, D, along polyphenols xanthohumol, fermented papaya, peanuts, berry extracts, demonstrate support promote through mechanisms that modulate diversity reduce inflammation. However, observed changes in were modest inconsistent studies. While preliminary evidence suggests may benefit heterogeneity existing limits immediate applicability. Additionally, more robust RCTs needed substantiate guide future interventions.

Язык: Английский

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Peanut meal-derived bioactive compounds: Extraction, co-extrusion encapsulation and neuroprotection against aluminum-induced Alzheimer's disease via in silico and in vivo studies

Phytomedicine Plus, Год журнала: 2024, Номер 4(3), С. 100588 - 100588

Опубликована: Июнь 7, 2024

Peanut meal (seeds waste with the red skin) contains antioxidants and anti-inflammatory compounds, which protect cells from oxidative stress inflammation. Hypothesis: This byproduct can be used to produce nutraceutical functional food items that may become popular. Methods: Ultrasound-assisted extraction was prepare peanut extracts at various times different solvents of 90 % (acetone, ethanol, methanol, acetic acid ethyl ester). Acetone extracting (for 20 min ) demonstrated highest total phenolic content (83.78 mg GAE/g meal) DPPH scavenging activity (95.83 %). extract (PME) analyzed by HPLC encapsulated using sodium alginate via co-extrusion technique. The alginate/PME microbeads were studied for their morphology release compounds. Results: results molecular docking a strong binding affinity, implying identified compounds in PME inhibit acetylcholinesterase. Through vivo study, it revealed antioxidant effects AlCl3-treated rats. Additionally, reduced acetylcholinesterase while elevating levels dopamine serotonin compared Conclusion: work provided valuable contributions towards valorization byproducts, highlighting potential neuroprotective effect against aluminum-induced Alzheimer's disease.

Язык: Английский

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Journal of functional foods special issue: Phenolic compounds and their impact on the gut-brain axis

Journal of Functional Foods, Год журнала: 2024, Номер 116, С. 106171 - 106171

Опубликована: Апрель 12, 2024

Язык: Английский

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