The influence of Akkermansia muciniphila on intestinal barrier function
Chunyan Mo,
Xiran Lou,
Jinfang Xue
и другие.
Gut Pathogens,
Год журнала:
2024,
Номер
16(1)
Опубликована: Авг. 3, 2024
Intestinal
barriers
play
a
crucial
role
in
human
physiology,
both
homeostatic
and
pathological
conditions.
Disruption
of
the
intestinal
barrier
is
significant
factor
pathogenesis
gastrointestinal
inflammatory
diseases,
such
as
bowel
disease.
The
profound
influence
gut
microbiota
on
diseases
has
sparked
considerable
interest
manipulating
it
through
dietary
interventions,
probiotics,
fecal
transplantation
potential
approaches
to
enhance
integrity
barrier.
Numerous
studies
have
underscored
protective
effects
specific
their
associated
metabolites.
In
recent
years,
an
increasing
body
research
demonstrated
that
Akkermansia
muciniphila
(A.
muciniphila,
Am)
plays
beneficial
various
including
diabetes,
obesity,
aging,
cancer,
metabolic
syndrome.
It
gaining
popularity
regulator
influences
flora
recognized
'new
generation
probiotics'.
Consequently,
may
represent
target
promising
therapy
option
for
diseases.
This
article
systematically
summarizes
Am
gut.
Specifically,
we
carefully
discuss
key
scientific
issues
need
resolution
future
regarding
bacteria
represented
by
Am,
which
provide
insights
application
drugs
targeting
clinical
treatment.
Язык: Английский
Hawthorn Pectin Alleviates DSS-Induced Colitis in Mice by Ameliorating Intestinal Barrier Function and Modulating Gut Microbiota
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Pectin,
as
a
kind
of
soluble
dietary
fiber
in
hawthorns,
exhibits
wide
range
biological
activities.
Nevertheless,
its
role
and
mechanism
ulcerative
colitis
(UC)
remain
unclear.
In
this
study,
the
effect
hawthorn
pectin
(HP)
against
dextran
sulfate
sodium
(DSS)-induced
UC
mice
underlying
were
evaluated.
HP
dramatically
alleviated
pathological
symptoms
related
to
mice,
displaying
an
increase
body
weight
colon
length
inhibition
damage.
Importantly,
inhibited
serum
levels
inflammation-related
factors
including
tumor
necrosis
factor-α,
IL-1β,
IL-6
well
decreased
number
F4/80-positive
macrophages
colon.
Moreover,
expression
ZO-1
occludin
proteins
intestinal
permeability
increased.
A
significant
decrease
dose-dependent
manner
at
gut
bacterial
genus
level
(such
Alistipes,
Colidextribacter,
Blautia)
was
observed
after
treatment.
improved
metabolic
pathways
microbiota
increased
concentrations
short-chain
fatty
acids
cecal
contents
mice.
Intriguingly,
fecal
transplantation
intervention
with
HP-derived
microbiome
notably
relieved
histopathological
changes
Conclusively,
our
study
provided
valuable
insights
into
potential
prebiotic
for
maintaining
health
confirmed
that
could
ameliorate
microbiota-dependent
manner.
Язык: Английский
Akkermansia muciniphila: promises and pitfallsfor next-generation beneficial microorganisms
Archives of Microbiology,
Год журнала:
2025,
Номер
207(4)
Опубликована: Март 4, 2025
Язык: Английский
Akkermansia muciniphila protects against dopamine neurotoxicity by modulating butyrate to inhibit microglia-mediated neuroinflammation
International Immunopharmacology,
Год журнала:
2025,
Номер
152, С. 114374 - 114374
Опубликована: Март 7, 2025
Язык: Английский
A comprehensive update on the immunoregulatory mechanisms of Akkermansia muciniphila : insights into active ingredients, metabolites, and nutrient-driven modulation
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 18
Опубликована: Окт. 16, 2024
Akkermansia
muciniphila
(A.
muciniphila)
has
gained
recognition
as
a
pioneering
probiotic,
exhibiting
considerable
potential
to
enhance
immune
conditions
across
both
humans
and
animals.
The
health
benefits
of
A.
are
attributed
its
various
components,
including
outer
membrane
proteins
(PilQ
Amuc_1100),
secreted
(P9
AmTARS),
extracellular
vesicles,
metabolites
such
SCFAs,
ornithine
lipids,
γ-aminobutyric
acid,
cobalamin,
inosine.
dynamic
control
the
mucus
layer
by
plays
crucial
role
in
regulating
intestinal
mucosal
immunity.
Furthermore,
modulates
function
interacting
with
macrophages,
dendritic
cells,
T
lymphocytes,
Paneth
cells.
Increasing
abundance
gut
through
nutritional
strategies
represents
safe
effective
means
augment
function.
Various
polyphenols,
oligosaccharides,
polysaccharides
have
been
shown
elevate
levels
this
bacterium,
thereby
contributing
favorable
immunoregulatory
outcomes.
This
paper
delves
into
latest
research
advancements
related
probiotic
mechanisms
provides
an
overview
current
understanding
how
responds
nutrients.
These
insights
offer
theoretical
foundation
for
utilization
immunoregulation.
Язык: Английский