A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12091 - 12091
Опубликована: Ноя. 11, 2024
The
main
goal
of
this
systematic
review
on
the
flavonol
class
secondary
metabolite
quercetin
is
to
evaluate
and
summarize
existing
research
quercetin's
potential
health
benefits,
therapeutic
properties,
effectiveness
in
disease
prevention
treatment.
In
addition
evaluating
for
drug
development
with
fewer
side
effects
lower
toxicity,
type
attempts
collect
scientific
evidence
addressing
roles
as
an
antioxidant,
anti-inflammatory,
antibacterial,
anticancer
agent.
first
part,
we
analyze
various
flavonoid
compounds,
focusing
their
chemical
structure,
classification,
natural
sources.
We
highlight
most
recent
biological
activities
reported
literature.
Among
these
pay
special
attention
quercetin,
detailing
its
physicochemical
process
biosynthesis
plants.
also
present
sources
emphasize
such
antioxidant
anti-inflammatory
effects.
Additionally,
discuss
methods
enhance
bioavailability,
analyzing
latest
effective
delivery
systems
based
quercetin.
Язык: Английский
In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches
Computers in Biology and Medicine,
Год журнала:
2025,
Номер
187, С. 109754 - 109754
Опубликована: Фев. 4, 2025
Язык: Английский
Identification and Inhibition Mechanism of Novel Collagen-Derived Hyaluronidase Inhibitory Peptides
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106263 - 106263
Опубликована: Фев. 1, 2025
Язык: Английский
Micro- and nano-bubble mediated ultrasound-assisted extraction of quercetin from red onion peels using glycerol–water solvent
Journal of Molecular Liquids,
Год журнала:
2025,
Номер
unknown, С. 127492 - 127492
Опубликована: Апрель 1, 2025
Язык: Английский
The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SARS‐CoV‐2 infection in cultured human lung cells
BioFactors,
Год журнала:
2024,
Номер
50(6), С. 1268 - 1286
Опубликована: Июнь 17, 2024
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
binds
to
angiotensin-converting
enzyme
(ACE2)
on
host
cells,
via
its
spike
protein,
and
transmembrane
protease,
serine
(TMPRSS2)
cleaves
the
spike-ACE2
complex
facilitate
virus
entry.
As
rate-limiting
steps
for
entry,
modulation
of
ACE2
and/or
TMPRSS2
may
decrease
SARS-CoV-2
infectivity
COVID-19
severity.
In
silico
modeling
suggested
natural
bioactive
flavonoid
quercetin
can
bind
a
recent
randomized
clinical
trial
demonstrated
that
oral
supplementation
with
increased
recovery.
A
range
cultured
human
cells
were
assessed
co-expression
TMPRSS2.
Immortalized
Calu-3
lung
matured
at
an
air-liquid
interface
(Calu-3-ALIs),
established
as
most
appropriate.
Primary
bronchial
epithelial
(PBECs)
obtained
from
healthy
adult
males
(N
=
6)
under
submerged
conditions
corroborate
outcomes.
Upon
maturation
or
reaching
80%
confluence,
respectively,
Calu-3-ALIs
PBECs
treated
quercetin,
mRNA
protein
expression
by
droplet
digital
PCR
ELISA,
respectively.
infectivity,
effects
pre-
co-treatment
was
median
tissue
culture
infectious
dose
assay.
Quercetin
dose-dependently
decreased
in
both
after
4
h,
while
remained
suppressed
response
prolonged
treatment
lower
doses
(twice
daily
3
days).
also
acutely
ADAM17
mRNA,
but
not
ACE,
Calu-3-ALIs,
this
warrants
further
investigation.
PBECs,
successfully
infected
SARS-CoV-2;
however,
had
no
antiviral
effect,
neither
directly
nor
indirectly
through
downregulation
reaffirmed
be
optimal
cell
model
research
into
regulation
TMPRSS2,
without
need
prior
genetic
modification,
will
prove
valuable
future
disease
work.
However,
our
data
demonstrate
significant
promising
prophylactic
candidate
translate
infection
prevention.
Язык: Английский