Lactiplantibacillus plantarum FEED8 Biosynthesis of Pyranoanthocyanin (Cyanidin-3-glucoside-4-vinylcatechol) Improves Oxidative Stress and Inflammation of the Gut Microbiome in Cadmium-Exposed Mice

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

The study is to explore the biosynthesis of cyanidin-3-glucoside-4-vinylcatechol (C3G_VC) through Lactiplantibacillus plantarum-fermented caffeic acid and cyanidin-3-glucoside (C3G) extract (molar ratio = 1:30) in model medium. C3G_VC was isolated purified by a venusil ASB-C18 column with medium-pressure liquid chromatography (MPLC) system. chemical structure identified high-performance (HPLC), which showed maximum absorption wavelength 505.57 nm. This that Cd exposure mice induced liver damage, oxidative stress, inflammation gut microbiome. Our findings demonstrated intervention Cd-exposed significantly mitigated stress injury declining malondialdehyde (MDA) level increasing activity superoxide dismutase (SOD) glutathione peroxidase (GSH-PX) liver, meanwhile alleviating decreasing bile (BA) accelerating excretion fecal BA. Moreover, Cd_C3G_VC group elevated levels mRNA expression pro-inflammatory cytokines (IL6, IL1β, TNF-α) inhibited BA synthesis (CYP7A1) mice. fermentation results vitro had higher residue than cyanidin-3-glucoside. 16S rRNA high-throughput sequencing disclosed increased abundance Faecalibaculum unidentified_Lachnospiraceae. It noteworthy supplement Akkermansia. Overall, this potential decrease occurrence inflammatory maintain homeostasis regulating microflora.

Язык: Английский

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Degradation of sweet corn cob polysaccharides by ultrasound-assisted H2O2/Vc treatment: Structural characterization and hypoglycemic effects in vitro and in vivo

Food Research International, Год журнала: 2025, Номер unknown, С. 116354 - 116354

Опубликована: Апрель 1, 2025

Язык: Английский

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Polysaccharides from fermented garlic attenuate high‐fat diet‐induced obesity in mice through gut microbes

Journal of Food Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

Abstract The weight loss and lipid‐lowering effects of fermented garlic polysaccharides (BGP) in obese mice were analyzed by detecting the intestinal flora short‐chain fatty acids. An obesity model was established feeding a high‐fat diet (HFD) for 8 weeks. After euthanasia, biochemical index testing hematoxylin eosin staining performed. Spearman analysis used to assess relationship between 16S rRNA sequencing results acid content mouse feces. Compared with mice, BGP group had significantly reduced body serum triglycerides, total cholesterol, low‐density lipoprotein malondialdehyde, free acids serum. Moreover, reversed HFD‐induced gut microbiota dysbiosis, as indicated elevated populations Paraclostridium , Lachnospiraceae _UCG_006, Enterorhabdus ‐NK4A136. also increased contents acetic, propionic, butyric, valeric These indicate that may serve potential prebiotic agent modulates particular bacteria their byproducts play crucial role preventing diseases associated obesity.

Язык: Английский

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Bangia fusco-purpurea polysaccharide with ultra-high pressure assisted extraction alleviates dyslipidemia in high-fat diet induced mice

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 290, С. 138933 - 138933

Опубликована: Дек. 19, 2024

Язык: Английский

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