Effects of semaglutide on metabolism and gut microbiota in high-fat diet-induced obese mice DOI Creative Commons

Luyan Sun,

Bin Shang, Suyuan Lv

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Июнь 2, 2025

Background The purpose of this study was to explore how semaglutide, a GLP-1RA, regulates serum metabolism and gut microbiota improve obesity in mice whether fecal transplantation (FMT) can transmit the beneficial effects semaglutide recipient mice. Methods Male C57BL/6J were given standard diet (ND), high-fat (HFD), or with (SHF, 100 μg/kg). Fecal used transplant suspension supernatant (MT) bacteria from SHF group antibiotic-induced pseudo-germ-free Results showed that significantly reduced body weight, fat, FBG, insulin levels induced by diet, improved resistance sensitivity damage ( p < 0.05). This achieved regulating expression genes related lipid such as Pparα, Pparγ, Cpt1a , Pgc1α liver adipose tissue, well appetite-related Leptin, Agrp, Npy, Pomc hypothalamus. After stopping intervention 4 weeks, weight rebounded significantly. could Semaglutide affected metabolic pathways amino acid pyrimidine obese mice, reshaped composition proportion Conclusion In summary, inhibit food intake obesity, regulate Bacterial is key transmitting improvement brought about

Язык: Английский

Structural characteristics of a polysaccharide isolated from Lactaruis volemus Fr. and its anti-diabetic effects regulated by the modulation of gut microbiota and metabolites DOI
Yanan Wang,

Xinyi Qian,

Lingzhi Chen

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142294 - 142294

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Effects of semaglutide on metabolism and gut microbiota in high-fat diet-induced obese mice DOI Creative Commons

Luyan Sun,

Bin Shang, Suyuan Lv

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Июнь 2, 2025

Background The purpose of this study was to explore how semaglutide, a GLP-1RA, regulates serum metabolism and gut microbiota improve obesity in mice whether fecal transplantation (FMT) can transmit the beneficial effects semaglutide recipient mice. Methods Male C57BL/6J were given standard diet (ND), high-fat (HFD), or with (SHF, 100 μg/kg). Fecal used transplant suspension supernatant (MT) bacteria from SHF group antibiotic-induced pseudo-germ-free Results showed that significantly reduced body weight, fat, FBG, insulin levels induced by diet, improved resistance sensitivity damage ( p < 0.05). This achieved regulating expression genes related lipid such as Pparα, Pparγ, Cpt1a , Pgc1α liver adipose tissue, well appetite-related Leptin, Agrp, Npy, Pomc hypothalamus. After stopping intervention 4 weeks, weight rebounded significantly. could Semaglutide affected metabolic pathways amino acid pyrimidine obese mice, reshaped composition proportion Conclusion In summary, inhibit food intake obesity, regulate Bacterial is key transmitting improvement brought about

Язык: Английский

Процитировано

0