A peptide from Boletus griseus‐Hypomyces chrysospermus protects against hypertension and associated cardiac and renal damage through modulating RAAS and intestinal microbiota

Journal of Food Science, Год журнала: 2025, Номер 90(1)

Опубликована: Янв. 1, 2025

Abstract Hypertension is a major risk factor for many cardiovascular diseases, which can lead to kidney and heart disease, stroke, premature death. Inhibiting angiotensin‐converting enzyme (ACE) activity an effective method relieve hypertension. Previously, we screened active peptide KYPHVF (KF6) from Boletus griseus‐Hypomyces chrysospermus with excellent ACE inhibitory activity. This study further evaluated the antihypertensive of KF6 in vivo. at 10 mg/kg Captopril (CAP, positive control) were administrated spontaneous hypertensive rats (SHRs) 5 weeks. The results demonstrated that effectively lowered both diastolic blood pressure (DBP) systolic (SBP), decreased ACE, AGT, ALD, ANG II levels serum SHRs. Furthermore, cardiac renal injury SHRs ameliorated by through inhibiting fibrosis, inflammation, oxidative stress. Moreover, inhibited ACE‐ANG II‐AT1 axis while activating ACE2‐Ang (1‐7)‐MAS1L pathway, two mutually antagonistic axes RAAS, Additionally, improved intestinal microbiota composition, mainly increasing abundance Prevotella Phascolarctobacterium decreasing Alistipes , Clostridium_IV Nosocomiicoccus Allobaculum . Overall, promising lowering mitigating hypertension‐related damage. protective effect against hypertension attributed its ability modulate RAAS microbiota.

Язык: Английский

A type 4 resistant potato starch alters the cecal microbiome, gene expression and resistance to colitis in mice fed a Western diet based on NHANES data

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Feeding Versafibe 1490, a type 4 resistant starch, alters the cecal microbiome, gene expression and resistance to colitis in mice fed Western diet.

Язык: Английский

Dual Functions of Whey Protein Peptides: Investigating Antioxidant Properties and Mechanisms of Colitis Relief

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105733 - 105733

Опубликована: Дек. 1, 2024

Язык: Английский