Extraction methods, structural diversity and potential biological activities of Artemisia L. polysaccharides (APs): A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142802 - 142802
Опубликована: Апрель 1, 2025
Язык: Английский
Structural Characterization of a Novel Lactuca Sativa Polysaccharide and its Adjuvant Hypoglycemic Effect in Hfd/Stz-Induced Obese C57 Bl/6 J Mice
Опубликована: Янв. 1, 2025
A
novel
natural
polysaccharide
(LSP)
was
isolated
and
purified
from
Lactuca
sativa
L.
The
structure
of
LSP
characterized
using
various
techniques,
including
FT-IR,
IC,
Congo
red,
XRD,
DSC,
SEM,
AFM,
NMR.
Furthermore,
its
in
vivo
hypoglycemic
activity
as
an
adjuvant
studied
a
diabetic
mouse
model
induced
by
HFD/STZ.
findings
revealed
that
possesses
molecular
weight
1.3
×
10⁶
kDa,
with
primary
structural
elements
identified
→4)-α-D-Glcp-(1→,
→4,6)-α-Glcp-(1→,
α-Araf-(1→,
→6)-β-D-Galp-(1→,
→3,4)-β-Xylp-(1→,
→4)-β-D-GalpA-(1→.
contains
Ara,
Gal,
Glc,
Xyl
GalA
molar
ratio
0.44:1:2.07:2.11:0.77.
is
semi-crystalline
polymer
lacking
triple
helix
exhibiting
stable
thermal
properties
below
200°C.
Studies
on
demonstrated
the
conjunction
metformin
significantly
improved
effects,
decreased
body
weight,
boosted
antioxidant
capacity,
enhanced
lipid
profiles,
insulin
sensitivity,
hepatic
glycolysis-related
enzyme
activities
mice
compared
to
alone.
This
research
presents
conceptual
rationale
for
exploring
function
polysaccharides,
highlighting
their
potential
adjunctive
role
control
diabetes
mellitus.
Язык: Английский
Structural characterization of a novel Lactuca sativa L. polysaccharide and its adjuvant hypoglycemic effect in HFD/STZ-induced obese C57 BL/6 J mice
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106458 - 106458
Опубликована: Апрель 1, 2025
Язык: Английский
The current understanding of Artemisia argyi as a potential food and medicine homology
Food, Nutrition and Health.,
Год журнала:
2025,
Номер
2(1)
Опубликована: Апрель 20, 2025
Abstract
Artemisia
argyi
H.
Lév.
&
Vaniot,
also
known
as
mugwort,
wild
,
etc.,
is
a
perennial
herb
of
the
Asteraceae
family.
It
has
long
history
applications
in
food
and
traditional
medicine.
Modern
studies
have
shown
that
it
contains
various
ingredients
with
wide
range
bioactivities.
However,
research
application
still
face
some
challenges,
such
unclear
functional
mechanisms,
non-uniform
quality
standards.
To
get
most
current
understanding
research,
we
searched
PubMed,
ScienceDirect,
Springer,
China
National
Knowledge
Infrastructure,
CQVIP
Network
Database
using
keyword
"
Argyi
alone
combination
chemical
composition
characteristics
for
its
use,
botanical
characteristics,
composition,
pharmacological
effects,
edible
value,
safety,
industry
status.
The
relevant
literature
published
from
2000
to
present
was
included.
search
results
indicate
been
used
medicine
time.
Its
fresh
tender
leaves
prepare
food,
aged
medicinal
purposes.
Various
active
components
identified
volatile
oil,
extracts
derived
.
limited.
Clearly,
more
works
are
anticipated
thoroughly
investigate
establish
standards
uses
homology,
fully
develop
promote
individual
population
health.
Future
should
prioritize
elucidating
particularly
anti-inflammatory
antioxidant
pathways,
while
strengthening
assessments
nutritional
bioactive
profiles.
Such
efforts
will
advance
rational
utilization
both
medical
industries,
fostering
broader
disease
management
development.
Язык: Английский
Mechanistic Advances in Hypoglycemic Effects of Natural Polysaccharides: Multi-Target Regulation of Glycometabolism and Gut Microbiota Crosstalk
Molecules,
Год журнала:
2025,
Номер
30(9), С. 1980 - 1980
Опубликована: Апрель 29, 2025
Natural
polysaccharides
(NPs),
as
a
class
of
bioactive
macromolecules
with
multitarget
synergistic
regulatory
potential,
exhibit
significant
advantages
in
diabetes
intervention.
This
review
systematically
summarizes
the
core
hypoglycemic
mechanisms
NPs,
covering
structure-activity
relationships,
integration
gut
microbiota-metabolism-immunity
axis,
and
regulation
key
signaling
pathways.
Studies
demonstrate
that
molecular
weight,
branch
complexity,
chemical
modifications
NPs
mediate
their
activity
by
influencing
bioavailability
target
specificity.
improve
glucose
metabolism
through
multiple
pathways:
activating
insulin
signaling,
improving
resistance
(IR),
enhancing
glycogen
synthesis,
inhibiting
gluconeogenesis,
regulating
microbiota
homeostasis.
Additionally,
protect
pancreatic
β-cell
function
via
nuclear
factor
E2-related
2
(Nrf2)/Antioxidant
Response
Element
(ARE)
antioxidant
pathway
Toll-like
receptor
4
(TLR4)/nuclear
factor-κB
(NF-κB)
anti-inflammatory
pathway.
Clinical
application
still
requires
overcoming
challenges
such
resolving
complex
relationships
dynamically
integrating
cross-organ
signaling.
Future
research
should
focus
on
multi-omics
technologies
(e.g.,
metagenomics,
metabolomics)
organoid
models
to
decipher
action
networks
promote
translation
from
basic
clinical
applications.
Язык: Английский
Preliminary characterization of Ramaria botrytoides polysaccharide RB-P1-1 and analysis of its hypoglycemic effects by altering the gut microbiota and metabolites in mice with type 2 diabetes mellitus
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 138774 - 138774
Опубликована: Дек. 1, 2024
Язык: Английский