Emerging multi-drug resistant and extended-spectrum b-lactamase (ESBL)-positive enterotoxigenic E. coli (ETEC) clones circulating in aquatic environments and in patients DOI Creative Commons
Enrique Joffré, Alberto J. Martín‐Rodríguez,

Annie Justh de Neczpal

и другие.

One Health, Год журнала: 2025, Номер 20, С. 100968 - 100968

Опубликована: Янв. 10, 2025

Diarrheal disease pathogens often spread through water-borne routes. Enterotoxigenic Escherichia coli (ETEC) is a major bacterial agent causing diarrheal in children, adults, and travelers endemic areas. In addition, ETEC responsible for outbreaks of water food-borne gasteroenteritis globally, isolates also show robust survival capacity various environmental settings, including aquatic environments. During the last decade, studies have indicated rapid increase multi-drug resistant extended-spectrum β-lactamase (ESBL)-positive human-specific strains. These been found both sources human patients, warranting urgent need focused monitoring antibiotic resistance development ETEC. Whole genome sequencing (WGS) from environmental, animal, enables silico surveillance emerging pathogenic This method allows re-analysis genomic data, aiding identification new variants clones. By integrating data diverse inclusing sequenced isolates, we that certain clonal lineages e.g., those expressing toxin-colonization factor profiles STp/CS6, LT STh/CS2 + CS3, STh/CFA/I are more at risk to develop than other lineages. Comparizon multi-locus sequence types papers with WGS ST182, ST4, ST2332 ST be We conclude further on ETEC/E. genomes needed enhance our understanding dynamics evolution, relation virulence clinical isolates.

Язык: Английский

Occurrence and spread of carbapenemase‐producing Enterobacterales (CPE) in the food chain in the EU/EFTA. Part 1: 2025 update DOI Creative Commons
Ana Allende, Avelino Álvarez‐Ordóñez, Valeria Bortolaia

и другие.

EFSA Journal, Год журнала: 2025, Номер 23(4)

Опубликована: Апрель 1, 2025

Abstract Carbapenemase‐producing Enterobacterales (CPE) have been reported in the food chain 14 out of 30 EU/EFTA countries. Commonly genes are blaVIM‐1, blaOXA‐48 and blaOXA‐181, followed by blaNDM‐5 blaIMI‐1. Escherichia coli, target most studies, Enterobacter cloacae complex, Klebsiella pneumoniae complex Salmonella Infantis frequent CPE. E. coli isolates show a high clonal diversity. IncHI2 (blaVIM‐1 blaOXA‐162), IncC blaNDM‐1), IncX3 (blaNDM‐5 blaOXA‐181), IncI IncL (blaOXA‐48) plasmids frequently reported. Most reports from terrestrial food‐producing animals their environments – mainly pigs, bovines poultry with occasional meat thereof (targets EU monitoring follow up trace back investigations). Few studies investigated foods aquatic animal origin non‐animal origin, finding great CPE A notable increase number detections has observed, predominantly surge certain countries 2021 (blaOXA‐181, Italy) 2023 (blaOXA‐48, Spain; blaOXA‐48, blaOXA‐244 blaNDM‐5, Portugal). Very few data points to circumstantial evidence transmission, and/or horizontal gene spread within from/to humans. Various methods used detect characterise chain. Improvement sensitivity should be investigated. Ten specific contingency plans for control, being epidemiological investigations (e.g. trace‐back) common action included those plans. Overall, remain scarce bacterial species sources beyond systematically monitored. Recommendations fill gaps on other sources, dissemination pathways optimisation detection given. One Health approach address drivers is needed.

Язык: Английский

Процитировано

1
Genomic comparative analysis of Enterobacter asburiae harbouring a conjugative blaIMI−6-plasmid isolated from a public garden in Switzerland DOI Creative Commons

Yvonne Spahr,

Andrea Endimiani, Vincent Perreten

и другие.

European Journal of Clinical Microbiology & Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

0
Emerging multi-drug resistant and extended-spectrum b-lactamase (ESBL)-positive enterotoxigenic E. coli (ETEC) clones circulating in aquatic environments and in patients DOI Creative Commons
Enrique Joffré, Alberto J. Martín‐Rodríguez,

Annie Justh de Neczpal

и другие.

One Health, Год журнала: 2025, Номер 20, С. 100968 - 100968

Опубликована: Янв. 10, 2025

Diarrheal disease pathogens often spread through water-borne routes. Enterotoxigenic Escherichia coli (ETEC) is a major bacterial agent causing diarrheal in children, adults, and travelers endemic areas. In addition, ETEC responsible for outbreaks of water food-borne gasteroenteritis globally, isolates also show robust survival capacity various environmental settings, including aquatic environments. During the last decade, studies have indicated rapid increase multi-drug resistant extended-spectrum β-lactamase (ESBL)-positive human-specific strains. These been found both sources human patients, warranting urgent need focused monitoring antibiotic resistance development ETEC. Whole genome sequencing (WGS) from environmental, animal, enables silico surveillance emerging pathogenic This method allows re-analysis genomic data, aiding identification new variants clones. By integrating data diverse inclusing sequenced isolates, we that certain clonal lineages e.g., those expressing toxin-colonization factor profiles STp/CS6, LT STh/CS2 + CS3, STh/CFA/I are more at risk to develop than other lineages. Comparizon multi-locus sequence types papers with WGS ST182, ST4, ST2332 ST be We conclude further on ETEC/E. genomes needed enhance our understanding dynamics evolution, relation virulence clinical isolates.

Язык: Английский

Процитировано

0