Molecular Systems Design & Engineering, Год журнала: 2024, Номер 9(10), С. 977 - 999
Опубликована: Янв. 1, 2024
Complex multilayered tissues have been regenerated by extrusion-based 3D bioprinting with biocompatible polymers. Multilayer fabrications tissue-specific bioinks are possible controlling gel properties including interaction between layers.
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 262, С. 129923 - 129923
Опубликована: Фев. 6, 2024
Язык: Английский
Процитировано
21
International Journal of Biological Macromolecules, Год журнала: 2022, Номер 222, С. 1110 - 1126
Опубликована: Сен. 28, 2022
Язык: Английский
Процитировано
62
Gut Microbes, Год журнала: 2023, Номер 15(2)
Опубликована: Ноя. 10, 2023
Low molecular weight (6.5 kDa) Glycyrrhiza polysaccharide (GP) exhibits good immunomodulatory activity, however, the mechanism underlying GP-mediated regulation of immunity and gut microbiota remains unclear. In this study, we aimed to reveal mechanisms using cyclophosphamide (CTX)-induced immunosuppressed intestinal mucosal injury models. GP reversed CTX-induced structural damage increased number goblet cells, CD4+, CD8+ T lymphocytes, mucin content, particularly by maintaining balance helper lymphocyte 1/helper 2 (Th1/Th2). Moreover, alleviated immunosuppression down-regulating extracellular regulated protein kinases/p38/nuclear factor kappa-Bp50 pathways increasing short-chain fatty acids level secretion cytokines, including interferon-γ, interleukin (IL)-4, IL-2, IL-10, IL-22, transforming growth factor-β3 immunoglobulin (Ig) M, IgG secretory A. treatment total species diversity microbiota. Microbiota analysis showed that promoted proliferation beneficial bacteria, Muribaculaceae_unclassified, Alistipes, Lachnospiraceae_NK4A136_group, Ligilactobacillus, Clostridia_vadinBB60_group, reduced abundance Proteobacteria CTX-derived bacteria (Clostridiales_unclassified, Candidatus_Arthromitus, Firmicutes_unclassified, Clostridium). The studies fecal transplantation pseudo-aseptic model conformed is crucial in regulation. shows great potential as an immune enhancer a natural medicine for treating inflammatory diseases.
Язык: Английский
Процитировано
31
The American Journal of Chinese Medicine, Год журнала: 2023, Номер 51(05), С. 1085 - 1104
Опубликована: Янв. 1, 2023
Ginseng is a very commonly used natural product in the world, and its two main species are Asian ginseng American ginseng. an adaptogenic botanical that reportedly protects body against stress, stabilizes physiological processes, restores homeostasis. Previously, different animal models contemporary research methodologies have been to reveal ginseng’s biomedical activities systems linked mechanisms of actions. However, human clinical observation data on effects attracted more attention from general public medical community. In this paper, after introduction phytochemistry species, we review positive studies, mainly conducted developed countries, performed over past 20 years. The reported presented several sections, conditions impacted by include diabetes; cardiovascular disorders; cognition, memory, mood; common cold flu; cancer fatigue well-being; quality life social functioning, etc. Administration demonstrated good safety record humans. Although encouraging beneficial obtained data, using study treatment regimen, only ranged mild moderate. Nonetheless, these could be valuable add-on therapy for patients receiving standard drug treatments. Additionally, as dietary supplement, possesses important role maintaining promoting health. We believe future trials should improved, particularly providing detailed herbal control information. With solid effectiveness well-designed, carefully executed trial, meritoriously medicine will widely consumers patients.
Язык: Английский
Процитировано
29
Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(3), С. 1735 - 1747
Опубликована: Янв. 12, 2023
The use of diversified ginseng extracts in health-promoting foods is difficult to differentiate, as they share bioactive ginsenosides among different Panax species (e.g., P. ginseng, quinquefolius, notoginseng, and japonicus) parts root, leaf, flower). This work was designed develop a pseudo-targeted metabolomics approach discover ginsenoside markers facilitating the precise authentication its compound formulation products (CFPs). Versatile mass spectrometry experiments on QTrap spectrometer achieved classified characterization neutral, malonyl, oleanolic acid-type ginsenosides, with 567 components characterized. A by multiple reaction monitoring (MRM) 262 ion pairs could assist establish key identification points for 12 species. simultaneous detection 14 enabled from 15 ginseng-containing CFPs. strategy better performance differentiating compared full-scan high-resolution approach.
Язык: Английский
Процитировано
27
Carbohydrate Polymers, Год журнала: 2023, Номер 321, С. 121284 - 121284
Опубликована: Авг. 14, 2023
Polysaccharide-based gold nanomaterials have attracted great interest in biomedical fields such as cancer therapy and immunomodulation due to their prolonged residence time vivo enhanced immune response. This review aims provide an up-to-date comprehensive summary of polysaccharide-based Au NMs synthesis, including mechanisms, polysaccharide structure-effects, anticancer activity. Firstly, research progress on the synthesis mechanism was addressed, which included three types based variety polysaccharides reaction environment: breaking glycosidic bonds via (III) or base-mediated production highly reduced intermediates, reduction free hydroxyl groups molecules, amino molecules. Then, potential effects structure characteristics (molecular weight, composition monosaccharides, functional groups, bonds, chain conformation) conditions (the temperature, time, pH, concentration precursor polysaccharides) size shape were explored. Finally, current status summarized before reaching our conclusions perspectives.
Язык: Английский
Процитировано
22
Carbohydrate Polymer Technologies and Applications, Год журнала: 2024, Номер 7, С. 100430 - 100430
Опубликована: Янв. 11, 2024
This work characterized the structural features and investigated immunomodulatory activity of an alkaline-precipitated polysaccharide fraction produced by Chaetomium globosum CGMCC 6882 (CGP-AP) in RAW 264.7 macrophages. The CGP-AP yield was 0.93 ± 0.08 g/L, which contained 98.33% 2.04% (w/w) carbohydrate 1.52% 0.26% protein. Structural analysis showed that comprised glucose (99.51%) arabinose (0.49%), its weight (Mw) number (Mn) average molecular weights were 0.948 0.55 kDa, polydispersity (Mw/Mn) 1.724. In vitro results show stimulated nitric oxide production tumor necrosis factor-α, interleukin (IL)-1β, IL-6, IL-8 secretion via upregulation expression levels related genes Meanwhile, upregulated proinflammatory (inducible synthase cyclooxygenase-2 COX-2). Furthermore, improved antioxidant status cells increasing antioxidase (superoxide dismutase, catalase, glutathione peroxidase) enhancing mRNA nuclear factor erythroid-2 2. above indicate may be used as a potential immunomodulator pharmaceutical industry.
Язык: Английский
Процитировано
11
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 313, С. 124124 - 124124
Опубликована: Март 6, 2024
Язык: Английский
Процитировано
8
Frontiers in Nutrition, Год журнала: 2022, Номер 9
Опубликована: Сен. 9, 2022
Traditional Chinese medicines (TCM), as the unique natural resource, are rich in polysaccharides, polyphenols, proteins, amino acid, fats, vitamins, and other components. Hence, TCM have high medical nutritional values. Polysaccharides one of most important active components TCM. Growing reports indicated that polysaccharides (TCMPs) various biological activities, such antioxidant, anti-aging, immunomodulatory, hypoglycemic, hypolipidemic, anti-tumor, anti-inflammatory, activities. research progresses future prospects TCMPs must be systematically reviewed to promote their better understanding. The aim this review is provide comprehensive systematic recombinant information on extraction, purification, structure, chemical modification, potential mechanism support therapeutic effects health functions. findings new valuable insights theoretical basis for development TCMPs.
Язык: Английский
Процитировано
28
Nutrients, Год журнала: 2023, Номер 15(13), С. 3019 - 3019
Опубликована: Июль 3, 2023
Dietary plant polysaccharides, one of the main sources natural possess significant cancer prevention activity and potential development value in food medicine fields. The anti-tumor mechanisms polysaccharides are mainly elaborated from three perspectives: enhancing immunoregulation, inhibiting tumor cell growth invasion metastasis. immune system plays a key role progression, immunomodulation is considered pathway for or treatment. Although much progress has been made revealing relationship between huge challenges still met research polysaccharides. Results suggest that certain polysaccharide types glycosidic linkage forms significantly affect biological immunoregulation. At present, vitro effects immunoregulation dietary widely reported articles; however, vivo deserving further investigation. In this paper, aspects behind polysaccharides' achieved through cells mediatory gut microbiota systematically summarized, with aim encouraging future on use prevention.
Язык: Английский
Процитировано
21