Deleted Journal,
Год журнала:
2023,
Номер
unknown, С. 18 - 46
Опубликована: Ноя. 28, 2023
GINSENOSIDES,
the
principal
constituent
of
plants
from
genus
Panax,
have
been
indicated
in
multitudinous
ailments
by
Homos
sapiens,
for
more
than
2
millennia.
Mostly
and
notably
ginsenosides,
mainstay
Chinese
herbal
system
medication,
are
harnessed
multifarious
disorders
viz.
Neurodegenerative
diseases,
Diabetes
mellitus,
Cardiovascular
abnormalities,
Septic
shock,
inflammatory
disorders,
Obesity
most
striking
all
owing
to
prevalent
circumstances
potential
manage,
even
treat
COVID-19,
albeit
empirically.
Whereas,
considering
plant
itself,
it
strikes
researcher
as
perennial
although,
with
significantly
slow
progress.
The
spectrum
review
encompasses
functional
reach
ginsenosides
special
emphasis
on
antiplatelet
therapeutics,
conjunction
notoriety
prospect
compounds
multitude
disorders.
However,
mechanism
which
edifice,
antithrombotic
efficiency
is
contingent,
expressed
keen
interest.
Ultimately,
root
or
its
extract,
evidenced
be
sufficiently
effective
curbing
foresaid
whether
authenticated
systematic
review,
clinical
trials,
mechanistic
patterns
animal
investigations.
Overall,
herb
shows
immense
packaged
into
a
unit
dosage
form
brought
market
especially
an
agent.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(16), С. 12732 - 12732
Опубликована: Авг. 12, 2023
Sepsis
is
a
serious
disease
with
high
mortality
and
has
been
hot
research
topic
in
medical
recent
years.
With
the
continuous
reporting
of
in-depth
on
pathological
mechanisms
sepsis,
various
compounds
have
developed
to
prevent
treat
sepsis.
Natural
small-molecule
play
vital
roles
prevention
treatment
sepsis;
for
example,
such
as
resveratrol,
emodin,
salidroside,
ginsenoside,
others
can
modulate
signaling
through
NF-κB,
STAT3,
STAT1,
PI3K,
other
pathways
relieve
inflammatory
response,
immunosuppression,
organ
failure
caused
by
Here,
we
discuss
functions
natural
preventing
treating
This
review
will
lay
theoretical
foundation
discovering
new
that
potentially
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2593 - 2593
Опубликована: Март 13, 2025
Colorectal
cancer
(CRC)
poses
a
significant
health
burden
worldwide
and
necessitates
novel
treatment
approaches
with
fewer
side
effects
than
conventional
chemotherapy.
Many
natural
compounds
have
been
tested
as
possible
treatments.
Plants
in
the
genus
Panax
widely
studied
due
to
their
therapeutic
potential
for
various
diseases
such
inflammatory
disorders
cancers.
Extracts
from
plants
of
activate
upstream
signals,
including
those
related
autophagy
generation
reactive
oxygen
species,
induce
intrinsic
apoptosis
CRC
cells.
The
root
extract
notoginseng
(P.
notoginseng)
regulated
gut
microbiota
enhance
T-cell-induced
immune
response
against
CRC.
Protopanaxadiol
(PPD)-type
ginsenosides,
especially
Rh2,
Rg3,
Rb1,
Rb2,
significantly
reduced
proliferation
cells
tumor
size
xenograft
mouse
model,
well
targeting
programmed
death
(PD)-1
block
checkpoint
Moreover,
modified
nanocarriers
ginsenosides
upregulated
drug
efficacy,
showing
that
can
also
be
utilized
carriers.
An
increasing
body
studies
has
demonstrated
curing
Ginsenosides
are
promising
active
Panax,
which
support
activity
therapies.
Molecules,
Год журнала:
2024,
Номер
29(7), С. 1455 - 1455
Опубликована: Март 24, 2024
Intracellular
protein
complexes,
known
as
inflammasomes,
activate
caspase-1
and
induce
the
secretion
of
pro-inflammatory
cytokines,
namely
interleukin
(IL)-1β
-18.
Korean
Red
Ginseng
extract
(RGE)
is
a
immunomodulator
potential
candidate
for
regulation
inflammasomes.
The
saponins,
such
ginsenosides,
RGE
inhibit
inflammasome
signaling,
while
non-saponin
substances
containing
amino
sugars
promote
priming
step,
up-regulating
components
(pro-IL-1β,
NLRP3,
caspase-1,
Asc).
In
this
study,
sugar-enriched
fraction
(ASEF),
which
increases
only
components,
including
sugars,
without
changing
concentration
saponin
substances,
was
used
to
investigate
whether
or
would
have
greater
impact
on
step.
When
murine
macrophages
were
treated
with
ASEF,
gene
expression
inflammatory
cytokines
(IL-1α,
TNFα,
IL-6,
IL-10)
increased.
Additionally,
ASEF
induced
step
but
did
not
affect
activation
IL-1β,
cleavage
formation
Asc
pyroptosome.
Furthermore,
upregulation
by
blocked
inhibitors
Toll-like
receptor
4
signaling.
Maltol,
main
constituent
promoted
inhibited
inflammasome,
arginine,
arginine–fructose–glucose,
fructose–arginine,
other
constituents
had
no
effect
either
Thus,
certain
in
RGE,
excluding
maltol,
are
believed
be
that
prepares
NLRP3
appears
thereby
contributing
immune-boosting
effects
RGE.
Journal of Ginseng Research,
Год журнала:
2024,
Номер
48(4), С. 428 - 434
Опубликована: Апрель 7, 2024
Platelet–leukocyte
aggregates
(PLAs)
play
important
roles
in
cardiovascular
disease
and
sepsis.
Red
ginseng
extract
(RGE)
has
been
well-studied
for
its
antiplatelet
anti-inflammatory
activities.
However,
the
potential
inhibitory
effects
of
RGE
on
PLA
have
not
investigated.
Six-week-old
ICR
mice
were
given
oral
gavage
7
days,
followed
by
an
intraperitoneal
injection
15
mg/kg
lipopolysaccharide.
Mice
euthanized
24
h
later,
blood
samples
collected
further
analysis.
Flow
cytometry
was
utilized
to
sort
populations
PLAs
platelet–neutrophil
(PNAs).
By
using
confocal
microscopy,
PNAs
validated.
Morphological
changes
platelets
leukocytes
visualized
with
scanning
electron
microscopy.
Expressions
tissue
factor
(TF)
platelet
4
(PF4)
investigated
enzyme-linked
immunosorbent
assay.
Populations
activated
platelets,
PNAs,
significantly
increased
LPS-induction.
Treatment
200
400
decreased
activation.
Moreover,
reduced.
visible
septic
mice,
this
attenuated
treatment
RGE.
Morphologically,
sepsis-induced
activation
fibrin
formation
blood.
This
reduced
treatment.
Sepsis-induced
increase
plasma
levels
TF
PF4
also
study
shows
that
is
a
therapeutic
reduces
targets
PNA
formation.
Detailed
mechanisms
should
be
studied.
