Deleted Journal,
Год журнала:
2023,
Номер
unknown, С. 18 - 46
Опубликована: Ноя. 28, 2023
GINSENOSIDES,
the
principal
constituent
of
plants
from
genus
Panax,
have
been
indicated
in
multitudinous
ailments
by
Homos
sapiens,
for
more
than
2
millennia.
Mostly
and
notably
ginsenosides,
mainstay
Chinese
herbal
system
medication,
are
harnessed
multifarious
disorders
viz.
Neurodegenerative
diseases,
Diabetes
mellitus,
Cardiovascular
abnormalities,
Septic
shock,
inflammatory
disorders,
Obesity
most
striking
all
owing
to
prevalent
circumstances
potential
manage,
even
treat
COVID-19,
albeit
empirically.
Whereas,
considering
plant
itself,
it
strikes
researcher
as
perennial
although,
with
significantly
slow
progress.
The
spectrum
review
encompasses
functional
reach
ginsenosides
special
emphasis
on
antiplatelet
therapeutics,
conjunction
notoriety
prospect
compounds
multitude
disorders.
However,
mechanism
which
edifice,
antithrombotic
efficiency
is
contingent,
expressed
keen
interest.
Ultimately,
root
or
its
extract,
evidenced
be
sufficiently
effective
curbing
foresaid
whether
authenticated
systematic
review,
clinical
trials,
mechanistic
patterns
animal
investigations.
Overall,
herb
shows
immense
packaged
into
a
unit
dosage
form
brought
market
especially
an
agent.
Electronic Journal of Biotechnology,
Год журнала:
2023,
Номер
66, С. 67 - 74
Опубликована: Сен. 20, 2023
Ginsenoside
Rg1
has
been
studied
to
improve
systemic
inflammatory
injury
induced
by
sepsis,
but
its
mechanism
is
not
fully
understood.
The
objective
of
this
study
was
explore
the
potential
molecular
which
ameliorates
septic
intestinal
barrier
function
impairment.
In
vitro
and
in
vivo
models
sepsis
were
established
LPS
induction
CLP
surgery,
administered.
Meanwhile,
miR-30e-5p/FBXO11
axis
regulated
transfection.
LDH
assay,
CCK-8,
flow
cytometry
utilized
assess
cell
damage.
HE
staining
TUNEL
applied
pathological
lesions
colon.
ELISA
Western
blot
employed
evaluate
changes
cytokines,
apoptotic
proteins,
signaling
pathway
tight
junction
proteins
tissues
cells.
Dual
luciferase
reporting
assay
RIP
evaluated
targeting
relationship
miR-30e-5p/FBXO11.
administration
or
miR-30e-5p
upregulation
alleviated
LPS-induced
apoptosis
Caco2
cells,
decreased
cytokines
levels,
enhanced
proliferation,
promoted
protein
expression,
inhibited
p65
phosphorylation.
These
beneficial
effects
compensated
knockdown
FBXO11
overexpression.
Animal
studies
have
also
yielded
consistent
results.
Mechanistically,
performed
role
upregulating
inhibiting
expression.
protects
regulating
axis.
data
provide
new
insights
into
development
targeted
agents
for
understanding
Rg1's
therapeutic
mechanisms.
Materials & Design,
Год журнала:
2024,
Номер
245, С. 113291 - 113291
Опубликована: Сен. 1, 2024
Cytokin
storms
play
a
key
role
in
the
pathogenesis
of
acute
lung
injury
(ALI)
caused
by
sepsis,
which
pulmonary
macrophage
PANoptosis
is
involved.
At
present,
main
treatment
methods
for
sepsis-induced
ALI
are
antibiotics
and
fluid
resuscitation,
but
efficacy
these
unsatisfactory
enough;
therefore,
development
new
therapeutic
urgently
needed.
In
this
study,
we
developed
novel
bionic
nanoparticle
(R@ZQC
NPs)
using
ZIF-8
nanoparticles
as
carrier,
internally
supported
with
ginsenoside
Rb1,
externally
coated
quaternated
chitosan
membrane
layer
layer.
The
biomimetic
controlled
release
had
good
biocompatibility,
strong
antibacterial
activity,
targeted
inhibition
PANoptosis.
vitro
vivo,
R@ZQC
NPs
effectively
inhibited
activity
Escherichia
coli
reduced
mitochondrial
damage
activating
AMPK
pathway,
thus
alleviating
inflammatory
response
ameliorating
ALI.
summary,
study
revealed
great
potential
antimicrobial
reduction
represents
first
attempt
This
provides
ideas
strategies
clinical
Deleted Journal,
Год журнала:
2023,
Номер
unknown, С. 18 - 46
Опубликована: Ноя. 28, 2023
GINSENOSIDES,
the
principal
constituent
of
plants
from
genus
Panax,
have
been
indicated
in
multitudinous
ailments
by
Homos
sapiens,
for
more
than
2
millennia.
Mostly
and
notably
ginsenosides,
mainstay
Chinese
herbal
system
medication,
are
harnessed
multifarious
disorders
viz.
Neurodegenerative
diseases,
Diabetes
mellitus,
Cardiovascular
abnormalities,
Septic
shock,
inflammatory
disorders,
Obesity
most
striking
all
owing
to
prevalent
circumstances
potential
manage,
even
treat
COVID-19,
albeit
empirically.
Whereas,
considering
plant
itself,
it
strikes
researcher
as
perennial
although,
with
significantly
slow
progress.
The
spectrum
review
encompasses
functional
reach
ginsenosides
special
emphasis
on
antiplatelet
therapeutics,
conjunction
notoriety
prospect
compounds
multitude
disorders.
However,
mechanism
which
edifice,
antithrombotic
efficiency
is
contingent,
expressed
keen
interest.
Ultimately,
root
or
its
extract,
evidenced
be
sufficiently
effective
curbing
foresaid
whether
authenticated
systematic
review,
clinical
trials,
mechanistic
patterns
animal
investigations.
Overall,
herb
shows
immense
packaged
into
a
unit
dosage
form
brought
market
especially
an
agent.
