Systematic Evaluation and Identification of Anti-Inflammatory and Anti-Aging Ginseng Peptides for Skincare Applications DOI Creative Commons

Z. C. Xia,

Wei Liu,

Fang Zeng

и другие.

Cosmetics, Год журнала: 2025, Номер 12(2), С. 85 - 85

Опубликована: Апрель 21, 2025

This study explores the potential of ginseng-derived peptides (GPs) as multifunctional bioactive agents for skincare. Unlike previous research into ginseng saponins and polysaccharides, we identified that extracts containing water-soluble small molecules polypeptides exhibit potent antioxidant, anti-inflammatory, anti-aging properties. In vitro assays revealed peptide extract (GPE) reduced reactive oxygen species (ROS) inflammatory cytokines (IL-6, TNF-α, IL-1β) in RAW264.7 macrophages while enhancing collagen synthesis human skin fibroblasts (HSFs). Validation using 3D epidermal dermal models further confirmed GPE’s ability to mitigate UV-induced damage, restore barrier proteins (filaggrin, loricrin), increase content. addition, screened 19 candidate from machine learning prioritized their interaction with aging inflammation-related targets. Three (QEGIYPNNDLYRPK, VDCPTDDATDDYRLK, ADEVVHHPLDKSSEVE) demonstrated significant collagen-promoting, anti-inflammatory effects cellular models. These findings highlight efficacy computational approaches identifying natural ingredients, positioning promising candidates innovative cosmeceutical formulations targeting inflammaging rejuvenation.

Язык: Английский

Ginsenosides analysis in different aged rhizomes of Panax sokpayensis: a Panax species from Indian Himalaya DOI
Shweta Rai, Bhusan Gurung, Dinesh Kumar

и другие.

Next research., Год журнала: 2025, Номер unknown, С. 100231 - 100231

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Systematic Evaluation and Identification of Anti-Inflammatory and Anti-Aging Ginseng Peptides for Skincare Applications DOI Creative Commons

Z. C. Xia,

Wei Liu,

Fang Zeng

и другие.

Cosmetics, Год журнала: 2025, Номер 12(2), С. 85 - 85

Опубликована: Апрель 21, 2025

This study explores the potential of ginseng-derived peptides (GPs) as multifunctional bioactive agents for skincare. Unlike previous research into ginseng saponins and polysaccharides, we identified that extracts containing water-soluble small molecules polypeptides exhibit potent antioxidant, anti-inflammatory, anti-aging properties. In vitro assays revealed peptide extract (GPE) reduced reactive oxygen species (ROS) inflammatory cytokines (IL-6, TNF-α, IL-1β) in RAW264.7 macrophages while enhancing collagen synthesis human skin fibroblasts (HSFs). Validation using 3D epidermal dermal models further confirmed GPE’s ability to mitigate UV-induced damage, restore barrier proteins (filaggrin, loricrin), increase content. addition, screened 19 candidate from machine learning prioritized their interaction with aging inflammation-related targets. Three (QEGIYPNNDLYRPK, VDCPTDDATDDYRLK, ADEVVHHPLDKSSEVE) demonstrated significant collagen-promoting, anti-inflammatory effects cellular models. These findings highlight efficacy computational approaches identifying natural ingredients, positioning promising candidates innovative cosmeceutical formulations targeting inflammaging rejuvenation.

Язык: Английский

Процитировано

0