Mechanistic Insights into Maltol-Mediated Reversal of Postmenopausal Osteoporosis via Regulation of CDK14 Ubiquitination in Macrophages DOI

Zhuoru Jin,

Yufei Wei, Zimo Zhou

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Maltol, primarily derived from Korean red ginseng, exhibits anti-inflammatory properties by modulating macrophage polarization and has potential therapeutic effects on postmenopausal osteoporosis, a condition linked to inflammation. This study explored the molecular mechanisms underlying maltol's ability inhibit M1 regulate osteoblast differentiation via macrophage-mediated pathways. Using in vitro vivo models, we demonstrated that maltol upregulates RNF213, which inhibits CDK14-Pdgfrβ signaling pathway, suppressing reducing NFκB phosphorylation pro-inflammatory cytokine production. Additionally, decreases TNFSF12 secretion, mitigating estrogen deficiency-induced apoptosis promoting differentiation. These findings highlight managing osteoporosis other inflammatory diseases.

Язык: Английский

Camellia Tea Saponin Ameliorates 5–Fluorouracil-Induced Damage of HaCaT Cells by Regulating Ferroptosis and Inflammation DOI Open Access

Tanrada Likitsatian,

Pimpisid Koonyosying, Narisara Paradee

и другие.

Nutrients, Год журнала: 2025, Номер 17(5), С. 764 - 764

Опубликована: Фев. 21, 2025

Background/Objective: Ferroptosis is an iron-dependent form of programmed cell death characterized by lipid peroxidation products (LPOs). A chemotherapeutic drug, 5–fluorouracil (5–FU), can induce epithelial mucositis and favor drug synergism with erastin in ferroptosis. Camellia tea saponin extract (TS) known to exert antioxidative properties. This study aims delineate the protective role TS mitigating 5–FU-induced ferroptosis inflammation human keratinocytes. Methods: HaCaT cells were induced 5–FU erastin, treated different doses, their viability was then determined. Levels cellular reactive oxygen species (ROS), LPOs, labile iron pool (LIP), glutathione (GSH), peroxidase 4 (GPX–4) activity, as well IL–6, IL–1β, TNF–α levels, wound healing properties assessed. Results: per se (at up 25 µg/mL) not toxic but unable restore baseline levels. The compound significantly diminished increases ROS, LIP, while restoring GSH content GPX–4 activity. Additionally, it suppressed cytokine production a concentration–dependent manner. Moreover, exerted wound-healing effects against skin injuries damage dose dependently. Conclusions: insights this work have identified biochemical mechanisms using protect keratinocyte inflammation. highlights promising adjunctive potential mitigation management chemotherapy-induced mucositis.

Язык: Английский

Процитировано

1
Mechanistic Insights into Maltol-Mediated Reversal of Postmenopausal Osteoporosis via Regulation of CDK14 Ubiquitination in Macrophages DOI

Zhuoru Jin,

Yufei Wei, Zimo Zhou

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Maltol, primarily derived from Korean red ginseng, exhibits anti-inflammatory properties by modulating macrophage polarization and has potential therapeutic effects on postmenopausal osteoporosis, a condition linked to inflammation. This study explored the molecular mechanisms underlying maltol's ability inhibit M1 regulate osteoblast differentiation via macrophage-mediated pathways. Using in vitro vivo models, we demonstrated that maltol upregulates RNF213, which inhibits CDK14-Pdgfrβ signaling pathway, suppressing reducing NFκB phosphorylation pro-inflammatory cytokine production. Additionally, decreases TNFSF12 secretion, mitigating estrogen deficiency-induced apoptosis promoting differentiation. These findings highlight managing osteoporosis other inflammatory diseases.

Язык: Английский

Процитировано

0