Pharmaceuticals,
Год журнала:
2024,
Номер
17(2), С. 155 - 155
Опубликована: Янв. 25, 2024
Infections
caused
by
antibiotic-resistant
bacteria
pose
a
significant
global
challenge.
This
study
explores
the
antibacterial
effects
of
bacteriophage-derived
endolysin,
LysAB1245,
against
important
pathogens,
including
Acinetobacter
baumannii,
Escherichia
coli,
Klebsiella
pneumoniae,
Pseudomonas
aeruginosa,
and
Staphylococcus
aureus.
We
determined
minimal
inhibitory
concentration
(MIC)
bactericidal
(MBC)
for
all
tested
isolates.
A
time–kill
was
conducted
to
evaluate
reduction
in
bacterial
survival
following
treatment
with
LysAB1245.
Additionally,
LysAB1245
on
P.
aeruginosa
K1455
methicillin-resistant
S.
aureus
(MRSA)
NPRC
001R-formed
biofilms
were
investigated.
The
MIC
MBC
isolates
ranged
from
4.68
9.36
µg/mL
18.72
µg/mL,
respectively.
demonstrated
more
than
4
log
CFU/mL
(99.99%)
within
6
h
at
2MIC.
(1/8–1/2MIC)
significantly
reduced
formed
MRSA
concentration-dependent
manner.
Furthermore,
scanning
electron
confocal
laser
microscopy
confirmed
potential
inhibition
3-day
established
abiotic
surfaces
upon
findings
indicate
that
endolysin
could
be
employed
as
new
alternative
therapeutic
anti-biofilm
agent
combating
biofilm-related
infections.
Case Studies in Chemical and Environmental Engineering,
Год журнала:
2024,
Номер
10, С. 100776 - 100776
Опубликована: Май 28, 2024
The
growing
global
population
challenges
the
food
industry
to
ensure
it
remains
safe
for
consumption.
Food
waste
caused
by
imbalances
between
production
and
handling
creates
significant
economic,
environmental,
social
risks.
However,
packaging
technology
innovation
has
emerged
as
a
powerful
tool,
offering
solution
extending
shelf
life
maintaining
product
quality.
Consumers'
increasing
interest
in
eco-friendly
driven
research
into
renewable
materials
low-toxicity
bioactive
components.
Gallic
acid,
promising
phenolic
compound,
holds
potential
preservation
sustainable
development.
Its
antibacterial
antifungal
properties
against
resistant
microbes
biofilm
formation,
its
ability
prevent
lipid
protein
oxidation,
color
indicator
monitoring
freshness
all
contribute
preservation.
incorporation
edible
polymers
offers
strategy
innovative
packaging.
Depending
on
dosage
material
composition,
loading
gallic
acid
within
polymer
matrix
can
improve
properties,
including
UV
barrier,
mechanical
strength,
water
vapor
oxygen
permeability.
This
article
reviews
of
developing
biodegradable,
active,
intelligent,
Future
directions
include
evaluating
acid's
toxicity,
dispersion
matrix,
pro-oxidative
activity,
compatibility
with
biodegradable
(especially
those
derived
from
agricultural
by-products),
migration
products,
stability
under
different
environmental
conditions.
sustainability
perspective
(environment,
social)
is
also
discussed.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 27, 2024
Abstract
Previous
studies
reported
microplastics
(MPs),
antibiotics,
and
antibiotic
resistance
genes
(ARGs)
in
wastewater
treatment
plants
(WWTPs).
There
is
still
a
lack
of
research
progress
on
the
origin,
fate,
impact
hazards
MPs
ARGs
WWTPs.
This
paper
fills
gap
this
regard.
In
our
search,
we
used
“microplastics”,
“antibiotic
genes”,
“wastewater
plant”
as
topic
terms
Web
Science,
checking
returned
results
for
relevance
by
examining
titles
abstracts.
study
mainly
explores
following
points:
(1)
origins
fate
MPs,
antibiotics
WWTPs;
(2)
mechanisms
action
sludge
biochemical
pools;
(3)
impacts
WWTPs
spread
ARGs;
(4)
harm
inflicted
environment
human
body.
Contaminants
sewage
such
ARGs,
antibiotic-resistant
bacteria
enter
soil
water.
can
travel
through
food
chain
thus
reach
humans,
leading
to
increased
illness,
hospitalization,
even
mortality.
will
enhance
understanding
among
they
inflict
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 4, 2024
The
development
of
antibiotic
resistance
compromises
the
effectiveness
our
most
effective
defenses
against
bacterial
infections,
presenting
a
threat
to
global
health.
To
date,
large
number
research
articles
exist
in
literature
describing
case
reports
associated
with
extensively
drug-resistant
(XDR)
and
multidrug-resistant
(MDR)
strains.
However,
these
findings
are
scattered,
making
it
time-consuming
for
researchers
locate
promising
results
there
remains
need
comparative
study
compile
from
various
geographical
regions
including
Kingdom
Saudi
Arabia.
Additionally,
no
has
yet
been
published
that
compares
genetic
variations
MDR
XDR
strains
identified
Arabia,
Middle
East,
Central
Europe,
Asian
countries.
This
attempts
provide
analysis
several
Arabia
alongside
other
Furthermore,
purpose
this
work
is
demonstrate
genes
underlying
mechanisms
seen
have
reported
cover
gap,
comprehensive
review
explores
complex
trends
growing
risk
posed
by
superbugs.
We
context
on
concerning
spread
bacteria
analyzing
fundamental
looking
into
individual
reports.
In
article,
we
compiled
cases
stories
countries
China,
Egypt,
India,
Poland,
Pakistan,
Taiwan.
will
serve
as
basis
highlighting
MDR,
poses
urgent
national
action
plans,
stewardship
programs,
preventive
measures,
novel
antibiotics
Kingdom.
