Liver International,
Год журнала:
2024,
Номер
44(5), С. 1093 - 1105
Опубликована: Фев. 26, 2024
Abstract
Plastics,
while
providing
modern
conveniences,
have
become
an
inescapable
source
of
global
concern
due
to
their
role
in
environmental
pollution.
Particularly,
the
focus
on
bisphenol
A
(BPA)
reveals
its
biohazardous
nature
and
association
with
liver
issues,
specifically
steatosis.
However,
research
indicates
that
BPA
is
just
one
facet
problem,
as
other
analogues,
microplastics,
nanoplastics
additional
plastic
derivatives
also
pose
potential
risks.
Notably,
implicated
every
stage
non‐alcoholic
fatty
disease
(NAFLD)
onset
progression,
surpassing
hepatitis
B
virus
a
primary
cause
chronic
worldwide.
As
contamination
tops
contaminants
list,
urgent
action
needed
assess
causative
factors
mitigate
impact.
This
review
delves
into
molecular
disruptions
linking
pollutant
exposure
diseases,
emphasizing
broader
connection
between
plastics
rising
prevalence
NAFLD.
Biomolecules,
Год журнала:
2023,
Номер
13(11), С. 1616 - 1616
Опубликована: Ноя. 5, 2023
Pregnancy
and
lactation
are
critical
periods
for
human
well-being
sensitive
windows
pollutant
exposure.
Bisphenol
A
(BPA)
is
well
demonstrated
as
a
toxicant
has
been
replaced
in
the
plastic
industry
with
other
bisphenol
analogs
that
share
similarities
structure
characteristics,
most
commonly
S
(BPS)
F
(BPF).
Maternal
exposure
to
BPS
or
BPF
can
result
their
accumulation
fetal
compartment,
leading
chronic
potentially
limiting
normal
growth
development.
This
review
summarizes
considerable
findings
of
epidemiological
experimental
studies
reporting
associations
between
impaired
Briefly,
available
indicate
two
during
pregnancy
multiple
disturbances
offspring,
including
restrictions,
neurological
dysfunctions,
metabolic
disorders
potential
persist
throughout
childhood.
The
occurrence
premature
births
may
also
be
attributed
bisphenols.
possible
mechanisms
actions
by
which
bisphenols
induce
such
effects
complex
interactions
physiological
mechanisms,
placental
functioning
development,
dysregulation
gene
expression,
altered
hormonal
balance,
immune
responses
induced
inflammations
oxidative
stress.
In
conclusion,
evidence
suggests
have
toxic
compartment
level
BPA.
Future
research
needed
provide
more
intensive
information;
long-term
research,
wide
scale
populations
different
settings,
recommended.
Public
awareness
regarding
safety
BPA-free
products
should
enhanced,
particular
emphasis
on
educating
individuals
responsible
children.
European Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
193, С. 106690 - 106690
Опубликована: Янв. 4, 2024
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
the
most
prevalent
chronic
hepatic
disorder
on
a
global
scale.
Atherosclerosis
(AS),
leading
cause
of
cardiovascular
diseases,
stands
as
primary
contributor
to
mortality
among
patients
diagnosed
with
NAFLD.
However,
precise
etiology
by
which
NAFLD
causes
AS
remains
unclear.
Exosomes
are
nanoscale
extracellular
vesicles
secreted
cells,
and
considered
participate
in
complex
biological
processes
promoting
cell-to-cell
organ-to-organ
communications.
As
containing
protein,
mRNA,
non-coding
RNA
other
bioactive
molecules,
exosomes
can
development
respectively.
Recently,
studies
have
shown
that
also
promote
via
secreting
exosomes.
Herein,
we
summarized
recent
advantages
pathogenesis
AS,
highlighted
role
mediating
information
exchange
between
AS.
Further,
discussed
how
play
prominent
enabling
diverse
organs,
delving
into
novel
avenue
for
investigating
link
diseases
their
associated
complications.
The
future
directions
emerging
challenges
listed
regarding
exosome-based
therapeutic
strategies
under
conditions.
Environment International,
Год журнала:
2025,
Номер
199, С. 109477 - 109477
Опубликована: Апрель 17, 2025
Bisphenol
S
(BPS)
has
become
extensively
used
in
the
manufacturing
of
consumer
products.
BPS
mainly
enters
body
through
food
and
water,
with
oral
exposure
targeting
gastrointestinal
tract.
However,
its
safety
profile
remains
contentious
warrants
further
investigation.
In
this
study,
we
aimed
to
assess
whether
exerts
harmful
effects
on
absence
overt
pathological
damage.
Our
results
revealed
that
although
did
not
lead
significant
histopathological
damage,
it
induced
intestinal
barrier
dysfunction.
Additionally,
vitro
investigations
utilizing
NCM460
cells
human-derived
colorectal
organoids
demonstrated
mitochondrial
reactive
oxygen
species
(ROS)
levels
endocrine
(EECs),
upregulating
expression
inflammatory
mediators
TNF-α
CXCL10.
Using
a
DSS-induced
colitis
mouse
model,
was
found
exacerbates
progression
diseases.
Analysis
single-cell
databases
reduction
CHGA,
functional
protein
enteroendocrine
patients
bowel
disease
(IBD).
The
CHGA
showed
negative
correlation
IL17.
Notably,
supplementation
3-Indoleglyoxylic
acid
effectively
mitigates
damage
by
BPS.
These
findings
highlight
role
oxidative
stress
IL-17/CXCL10/TNF-α
signaling
BPS-induced
demonstrate
therapeutic
potential
mitigating
these
effects.
Bisphenol
analogs
and
their
derivatives
have
been
identified
in
human
tissue
our
living
environment.
There
are
major
concerns
over
exposure
to
bisphenol
analogs,
especially
the
low-dose-
mixture-related
toxicities,
as
they
considered
potential
endocrine-disrupting
chemicals
that
may
cause
adverse
effects
multiple
organ
systems.
The
liver
is
a
critical
responsible
for
an
array
of
functions,
e.g.,
metabolism,
immunity,
digestion,
detoxification
vitamin
storage,
addition
being
leading
chemical
target
site.
In
this
literature
review
species,
we
discussed
metabolism
liver,
which
was
followed
by
discussions
analog-induced
toxicity
various
including
humans,
rodents
(mice
rats)
other
species
(chicken,
pig,
sheep,
etc.).
Further,
mechanisms
action
markers
damage
such
oxidative
stress,
apoptosis,
inflammation
fibrosis
were
discussed.
It
concluded
can
produce
toxic
on
different
through
mechanisms,
epigenetic
modifications
disruptions
cell
signaling
pathways,
gene
expression,
microbiome
metabolome.
More
research
should
be
conducted
study
than
A
underlying
action,
particular
causing
dysbiosis.
Understanding
injury
holds
promise
improving
prediction
from
environmental
chemicals,
risk
assessment
legislation.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(35), С. 15463 - 15474
Опубликована: Авг. 21, 2024
Many
environmental
pollutants
have
neurotoxic
effects,
but
the
initial
molecular
events
involved
in
these
effects
are
unclear.
Here,
zebrafish
were
exposed
to
neurotoxicant
bisphenol
S
(BPS,
1,
10,
or
100
μg/L)
from
embryonic
stage
larval
explore
ability
of
BPS
interfere
with
energy
metabolism
brain.
BPS,
which
is
similar
a
glucose
transporter
1
(GLUT1)
inhibitor,
inhibited
GLUT1
function
increased
mitochondrial
activity
brains
zebrafish.
Interestingly,
inhibitor
treatment
and
exposure
did
not
reduce
production
brain;
instead,
they
ATP
by
inducing
preferential
use
ketone
bodies.
Moreover,
promoted
protein
expression
purinergic
2X
receptor
2Y-mediated
phosphatidylinositol
signaling
pathway,
indicating
that
excess
acts
as
neurotransmitter
activate
under
BPS-induced
restriction
function.
inhibition
number
neurons
apoptosis
activating
ATP-purinergic
receptors
brain,
causing
excitatory
neurotoxicity.
Our
data
reveal
potential
mechanism
induced
may
represent
new
adverse
outcome
pathway.
