Chemosphere, Год журнала: 2024, Номер 369, С. 143856 - 143856
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Hazardous Materials, Год журнала: 2025, Номер 486, С. 137110 - 137110
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
1
Antioxidants, Год журнала: 2024, Номер 13(7), С. 786 - 786
Опубликована: Июнь 28, 2024
Previous research has established a correlation between PM2.5 exposure and aging-related cardiovascular diseases, primarily in blood vessels. However, the impact of on cardiomyocyte aging remains unclear. In this study, we observed that extractable organic matter (EOM) from led to cellular senescence H9c2 cardiomyoblast cells, as characterized by an increase percentage β-galactosidase-positive elevated expression levels p16 p21, enhanced H3K9me3 foci. EOM also induced cell cycle arrest at G1/S stage, accompanied downregulation CDK4 Cyclin D1. Furthermore, significant elevation intracellular reactive oxygen species (ROS), mitochondrial ROS, DNA damage. Supplementation with antioxidant NAC effectively attenuated EOM-induced cardiac senescence. Our findings revealed activated aryl hydrocarbon receptor (AhR) signaling pathway, evidenced AhR translocation nucleus upregulation Cyp1a1 Cyp1b1. Importantly, antagonist CH223191 mitigated oxidative stress conclusion, our results indicate PM2.5-induced activation leads stress, damage, arrest, leading Targeting AhR/ROS axis might be promising therapeutic strategy for combating aging.
Язык: Английский
Процитировано
7
Environment & Health, Год журнала: 2024, Номер 2(3), С. 105 - 113
Опубликована: Янв. 18, 2024
Fine particulate matter (PM2.5) is a significant risk factor for birth defects. As the first and most important organ to develop during embryogenesis, heart's potential susceptibility PM2.5 has attracted growing concern. Despite several studies supporting cardiac developmental toxicity of PM2.5, diverse study types, models, end points have prevented integration mechanisms. In this Review, we present an adverse outcome pathway framework elucidate association between PM2.5-induced molecular initiating events outcomes. Activation aryl hydrocarbon receptor (AhR) excessive generation reactive oxygen species (ROS) were considered as events. The production ROS induced oxidative stress, endoplasmic reticulum DNA damage, inflammation, resulting in apoptosis. activation AhR inhibited Wnt/β-catenin then suppressed cardiomyocyte differentiation. Impaired differentiation persistent apoptosis resulted abnormalities structure function. All aforementioned been identified key (KEs). culmination these KEs ultimately led outcome, increased morbidity congenital heart defects (CHDs). This work contributes understanding causes CHDs promotes safety evaluation PM2.5.
Язык: Английский
Процитировано
6
Toxics, Год журнала: 2024, Номер 12(4), С. 274 - 274
Опубликована: Апрель 6, 2024
Particulate matter of size ≤ 2.5 μm (PM2.5) is a critical environmental threat that considerably contributes to the global disease burden. However, accompanied by rapid research progress in this field, existing on developmental toxicity still constrained limited data sources, varying quality, and insufficient in-depth mechanistic analysis. This review includes currently available epidemiological laboratory evidence comprehensively characterizes adverse effects PM2.5 developing individuals different regions various pollution sources. In addition, explores effect exposure ethnicities, genders, socioeconomic levels birth outcomes cardiopulmonary neurological development. Furthermore, molecular mechanisms involved health primarily encompass transcriptional translational regulation, oxidative stress, inflammatory response, epigenetic modulation. The primary findings novel perspectives regarding association between public were examined, highlighting need for future studies explore its composition, sex-specific effects. Additionally, further required delve deeper into more intricate underlying effectively prevent or mitigate harmful air human health.
Язык: Английский
Процитировано
5
The Science of The Total Environment, Год журнала: 2023, Номер 906, С. 167636 - 167636
Опубликована: Окт. 7, 2023
Язык: Английский
Процитировано
12
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 13897 - 13897
Опубликована: Сен. 9, 2023
Epigenetic methylation has been shown to play an important role in transcriptional regulation and disease pathogenesis. Recent advancements detection techniques have identified DNA N6-methyldeoxyadenosine (6mA) RNA N6-methyladenosine (m6A) as modifications at the sixth position of adenine RNA, respectively. While distributions functions 6mA m6A extensively studied prokaryotes, their roles mammalian brain, where they are enriched, still not fully understood. In this review, we provide a comprehensive summary current research progress on m6A, well associated writers, erasers, readers both levels. Specifically, focus potential fundamental biological pathways genome highlight significant regulatory neurodegenerative diseases.
Язык: Английский
Процитировано
11
Pharmacological Research, Год журнала: 2024, Номер 207, С. 107305 - 107305
Опубликована: Июль 11, 2024
Cardiomyopathy (CM) represents a heterogeneous group of diseases primarily affecting cardiac structure and function, with genetic epigenetic dysregulation playing pivotal role in its pathogenesis. Emerging evidence from the burgeoning field epitranscriptomics has brought to light significant impact various RNA modifications, notably N6-methyladenosine (m6A), 5-methylcytosine (m5C), N7-methylguanosine (m7G), N1-methyladenosine (m1A), 2′-O-methylation (Nm), 6,2′-O-dimethyladenosine (m6Am), on cardiomyocyte function broader processes vascular remodelling. These modifications have been shown influence key pathological mechanisms including mitochondrial dysfunction, oxidative stress, apoptosis, inflammation, immune response, myocardial fibrosis. Importantly, aberrations methylation machinery observed human CM cases animal models, highlighting critical methylating enzymes their potential as therapeutic targets or biomarkers for CM. This review underscores necessity deeper understanding context CM, illuminate novel avenues diagnostic tools, thereby addressing gap current management strategies this complex disease.
Язык: Английский
Процитировано
2
Journal of Hazardous Materials, Год журнала: 2024, Номер 476, С. 135004 - 135004
Опубликована: Июнь 26, 2024
Процитировано
1
Experimental and Therapeutic Medicine, Год журнала: 2024, Номер 29(1)
Опубликована: Окт. 29, 2024
Fine particulate matter (PM2.5) has become an important risk factor threatening human health. Epidemiological and toxicological investigations have revealed that PM2.5 not only leads to cardiovascular dysfunction, but it also gives rise various adverse health effects on the body, such as cerebrovascular diseases, cancers, neurodevelopmental disorders, depression autism. is able penetrate both respiratory placental barriers, thereby resulting in negative fetal development. A large body of epidemiological evidences suggested gestational exposure increases incidence congenital diseases offspring, including heart defects. In addition, animal model studies can disrupt normal development although potential molecular mechanisms yet be fully elucidated. The aim present review was provide a brief overview what currently known regarding underlying cardiac developmental toxicity offspring induced by PM2.5.
Язык: Английский
Процитировано
1
Chemosphere, Год журнала: 2024, Номер 369, С. 143856 - 143856
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0