Applied Sciences,
Год журнала:
2024,
Номер
14(16), С. 7280 - 7280
Опубликована: Авг. 19, 2024
Nanoplastics
(NPs)
represent
an
escalating
hazard
to
both
humans
and
the
ecosystem
due
their
pervasive
presence.
This
review
delves
into
(i)
widespread
occurrence
of
NPs
across
different
environmental
matrices,
including
food;
(ii)
routes
estimates
for
human
exposure;
(iii)
mechanisms
blood–brain
barrier
(BBB)
crossing;
(iv)
implications
health,
with
a
specific
focus
on
molecular
features
associated
neurotoxicity
neurodegenerative
processes.
The
impact
central
nervous
system,
ability
cross
BBB
underpinning
mechanisms,
potential
initiate
by
fostering
β-amyloid
aggregation,
interactions
metallo-enzymes
(such
as
superoxide
dismutase)
are
elucidated.
analysis
transcriptomics
epigenomic
results,
microRNA
dysregulation,
unveil
how
could
contribute
neurological
disorders.
need
considering
overlaps
among
diverse
pathogenetic
when
probing
effects
is
discussed.
Additional
urgent
needs
development
reliable
in
vitro
models
studies
able
mimic
complexity
system
exposure
such
more
environmentally
relevant
NPs.
Finally,
extremely
sensitive
detection
methodologies
quantify
biological
matrices
pressing
priority.
Environment International,
Год журнала:
2025,
Номер
197, С. 109323 - 109323
Опубликована: Фев. 7, 2025
Polystyrene
micro/nanoplastics
(MPs/NPs)
are
globally
recognized
environmental
concerns
due
to
their
widespread
pollution
and
detrimental
effects
on
physiological
functions.
However,
the
neurotoxic
underlying
mechanisms
of
MPs/NPs
brain
function
in
adolescents
remain
incompletely
understood.
This
study
investigated
polystyrene
neurobehavioral
adolescent
mice,
utilizing
multi-omic
analysis
molecular
biology
assays
explore
potential
mechanisms.
Following
oral
exposure
MPs
(5
μm)
or
NPs
(0.5
at
0.5
mg/day
for
4
weeks,
induced
more
severe
cognitive
impairment
mice
than
MPs,
as
assessed
by
Morris
water
maze
Y-maze
tests.
might
be
associated
with
neuron
loss
neurogenesis
inhibition
caused
NPs,
while
dendritic
spine
mediated
hippocampus.
Furthermore,
hippocampal
transcriptome
Western
blotting
indicated
involvement
PI3K/AKT
pathway
NPs-induced
neurotoxicity.
Meanwhile,
pronounced
disruptions
metabolome
gut
microbiota,
strong
correlations
were
observed
between
changes
metabolites
bacteria.
elucidated
toxicity
mechanism
inducing
providing
insights
into
toxicological
impacts
strategies
intervention.
The Science of The Total Environment,
Год журнала:
2024,
Номер
932, С. 172915 - 172915
Опубликована: Май 6, 2024
The
increasing
trend
regarding
the
use
of
plastics
has
arisen
an
exponential
concern
on
fate
their
derived
products
to
environment.
Among
these
derivatives,
microplastics
and
nanoplastics
(MNPs)
have
been
featured
for
associated
environmental
impact
due
low
molecular
size
high
surface
area,
which
prompted
ubiquitous
transference
among
all
interfaces.
Due
heterogenous
chemical
composition
MNPs,
study
particles
focused
a
number
studies,
as
result
myriad
physicochemical
properties
that
contribute
co-transference
wide
range
contaminants,
thus
becoming
major
challenge
scientific
community.
In
this
sense,
both
primary
secondary
MNPs
are
well-known
be
adscribed
industrial
urbanized
areas,
from
they
massively
released
environment
through
multiscale
level,
involving
atmosphere,
hydrosphere,
lithosphere.
Consequently,
much
research
conducted
understanding
interconnection
between
those
interfaces,
motivate
spread
contaminants
biological
systems,
being
mostly
represented
by
biosphere,
especially
phytosphere
and,
finally,
anthroposphere.
These
findings
highlighted
potential
hazardous
risk
human
health
different
mechanisms
environment,
requiring
deeper
approach
define
real
exposure.
As
result,
there
is
gap
knowledge
high-throughput
perspective.
review,
metabolomics-based
overview
interfaces
was
proposed,
considering
technology
highly
valuable
tool
decipher
opening
novel
perspective
contaminants.
Applied Sciences,
Год журнала:
2024,
Номер
14(16), С. 7280 - 7280
Опубликована: Авг. 19, 2024
Nanoplastics
(NPs)
represent
an
escalating
hazard
to
both
humans
and
the
ecosystem
due
their
pervasive
presence.
This
review
delves
into
(i)
widespread
occurrence
of
NPs
across
different
environmental
matrices,
including
food;
(ii)
routes
estimates
for
human
exposure;
(iii)
mechanisms
blood–brain
barrier
(BBB)
crossing;
(iv)
implications
health,
with
a
specific
focus
on
molecular
features
associated
neurotoxicity
neurodegenerative
processes.
The
impact
central
nervous
system,
ability
cross
BBB
underpinning
mechanisms,
potential
initiate
by
fostering
β-amyloid
aggregation,
interactions
metallo-enzymes
(such
as
superoxide
dismutase)
are
elucidated.
analysis
transcriptomics
epigenomic
results,
microRNA
dysregulation,
unveil
how
could
contribute
neurological
disorders.
need
considering
overlaps
among
diverse
pathogenetic
when
probing
effects
is
discussed.
Additional
urgent
needs
development
reliable
in
vitro
models
studies
able
mimic
complexity
system
exposure
such
more
environmentally
relevant
NPs.
Finally,
extremely
sensitive
detection
methodologies
quantify
biological
matrices
pressing
priority.
