Micro-nanoplastics pollution and mammalian fertility: a systematic review and meta-analysis

Theriogenology, Год журнала: 2025, Номер 238, С. 117369 - 117369

Опубликована: Фев. 26, 2025

Язык: Английский

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Weakened serum albumin binding-to-activated EGFR internalization in cellular accumulation for the synergistic toxicity of tetrabromobisphenol A and perfluorooctanoic acid

Environmental Chemistry and Ecotoxicology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Chlorocholine chloride exposure induced spermatogenic dysfunction via iron overload caused by AhR/PERK axis-dependent ferritinophagy activation

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 274, С. 116193 - 116193

Опубликована: Март 9, 2024

Chlorocholine chloride (CCC) is a plant growth regulator used worldwide that detectable in cereals, fruits and animal products. The health effects of CCC exposure have raised public concern. Our previous research showed decreased testosterone synthesis pubertal rats. However, little known about whether how impacts spermatogenesis. In this study, we BALB/c mice spermatogonia-derived GC-1 cells to examine CCC-induced spermatogenic dysfunction. vivo, led testicular weight, germ poor sperm quality. This effect worsened after cessation for the next 30 days. RNA-seq western blot analysis revealed induced aryl hydrocarbon receptor (AhR) signaling, endoplasmic reticulum stress (ERS) ferritinophagy. Increased iron content lipid peroxidation levels were also observed CCC-treated testes. vitro, it was identified overload mediated by enhanced ferritinophagy occurred cells, which might be attributed PERK pathway ERS. Further, first time, our study elucidated involvement AhR overload, aggravated oxidative damage via peroxidation. Considering adverse impact on rodents, supportive evidence from critical importance spermatogenesis male development, reproduction warrant increased attention.

Язык: Английский

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Molybdenum and cadmium co-induce apoptosis and ferroptosis through inhibiting Nrf2 signaling pathway in duck (Anas platyrhyncha) testes

Poultry Science, Год журнала: 2024, Номер 103(5), С. 103653 - 103653

Опубликована: Март 13, 2024

Cadmium (Cd) and high molybdenum (Mo) are injurious to the body. Previous research has substantiated that Cd Mo exposure caused testicular injury of ducks, but concrete mechanism is not fully clarified. To further survey toxicity co-exposure in testis, 40 healthy 8-day-old Shaoxing ducks (Anas platyrhyncha) were stochasticly distributed four groups raised with basic diet embracing (4 mg/kg Cd) or (100 Mo) both. At 16th week, testis tissues gathered. The characteristic ultrastructural changes related apoptosis ferroptosis observed both groups. Besides, repressed nuclear factor erythroid 2-related 2(Nrf2) pathway via decreasing Nrf2, Heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), Glutamate-cysteine ligase catalytic subunit (GCLC) modifier (GCLM) mRNA expression Nrf2 protein expression, then stimulated by elevating Bcl-2 antagonist/killer-1 (Bak-1), Bcl-2-associated X-protein (Bax), Cytochrome complex (Cyt-C), caspase-3 cleaved-caspase-3 rate, as well reducing B-cell lymphoma-2 (Bcl-2) ratio Bax, triggered upregulating Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4), transferrin receptor (TFR1) Prostaglandin-Endoperoxide Synthase 2 (PTGS2) levels, downregulating ferritin heavy chain (FTH1), light (FTL1), ferroportin (FPN1), solute carrier family 7 member 11 (SCL7A11) glutathione peroxidase (GPX4) levels. most obvious these indexes co-treated group. Altogether, results announced evoked inhibiting exacerbated variations.

Язык: Английский

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Enhanced cadmium ions capture performance with a dual-zinc metal-organic framework composite

Journal of Solid State Chemistry, Год журнала: 2024, Номер 335, С. 124703 - 124703

Опубликована: Апрель 8, 2024

Язык: Английский

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