Critical Reviews in Environmental Science and Technology, Год журнала: 2024, Номер unknown, С. 1 - 26
Опубликована: Сен. 3, 2024
Язык: Английский
Critical Reviews in Environmental Science and Technology, Год журнала: 2024, Номер unknown, С. 1 - 26
Опубликована: Сен. 3, 2024
Язык: Английский
Separation and Purification Technology, Год журнала: 2024, Номер 354, С. 128879 - 128879
Опубликована: Июль 19, 2024
Язык: Английский
Процитировано
10Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 295, С. 118118 - 118118
Опубликована: Апрель 1, 2025
Atrazine (ATR), a widely used herbicide, poses significant environmental and health risks due to its high solubility adsorption in soil. ATR exposure can lead nephrotoxicity humans animals. Curcumin (Cur), an active compound Curcuma species, is renowned for antioxidant anti-inflammatory properties, with potential mitigate chronic disease risks. We hypothesized that the addition of Cur could alleviate renal impairment associated carried out experiments using mice as subjects. This study investigates whether attenuate ATR-induced by modulating mitophagy apoptotic pathways. Our findings illustrate consumption attenuates induced ATR, evidenced lowered serum concentrations uric acid (UA), blood urea nitrogen (BUN), creatinine (CRE), established biomarkers injury. Moreover, enhances defense mechanisms ATR-exposed mice, indicated elevated levels total capacity (T-AOC), catalase (CAT), glutathione peroxidase (GSH-Px), alongside reduced malondialdehyde (MDA). Histopathological electron microscopy analyses further corroborate these findings, showing organelle damage, particularly mitochondrial ridge breakage vacuolization, increased autophagic lysosomes. PINK1/Parkin-mediated autophagy, PINK1, Parkin, LC3BII, P62 compared ATR-treated mice. mitigates pathway, down-regulation apoptosis-related genes (Cytochrome C (Cyto-C), Caspase3, Caspase9) pro-apoptotic marker (Bax), along up-regulation anti-apoptotic (Bcl-2) at both transcriptional translational In summary, demonstrates nephroprotective properties against injury through enhancement autophagy display actions, underscoring curative potency treatment caused ATR.
Язык: Английский
Процитировано
0Опубликована: Апрель 30, 2025
Язык: Английский
Процитировано
0Environmental Science Nano, Год журнала: 2024, Номер 11(9), С. 3693 - 3720
Опубликована: Янв. 1, 2024
The remediation of polluted water via graphene oxide or derived materials has captivated the momentous attention scientific community over past few years.
Язык: Английский
Процитировано
3Journal of Environmental Management, Год журнала: 2024, Номер 370, С. 122807 - 122807
Опубликована: Окт. 4, 2024
Язык: Английский
Процитировано
1Journal of Polymer Research, Год журнала: 2024, Номер 31(5)
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
0Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0Critical Reviews in Environmental Science and Technology, Год журнала: 2024, Номер unknown, С. 1 - 26
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
0