Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
73(9), С. 5067 - 5078
Опубликована: Фев. 13, 2025
This
study
investigates
the
uptake,
biotransformation,
and
phytotoxicity
of
sulfadiazine
(SDZ)
its
acetyl
derivative
N4-acetylsulfadiazine
(NASDZ)
in
rice.
Results
showed
that
rice
was
more
tolerant
to
NASDZ,
with
lower
malondialdehyde
reactive
oxygen
species
levels
but
higher
antioxidant
enzyme
activities
(SOD,
POD,
CAT).
The
maximum
accumulations
SDZ
roots
shoots
were
19.3
±
1.0
3.6
1.1
μg/g,
while
NASDZ
18.6
2.5
3.5
1.4
respectively.
exposure
generated
metabolic
intermediates,
including
deamination,
hydroxylation,
glycosylation,
acetylation,
formylation
products,
metabolism
documented
for
first
time.
Key
genes
involved
biotransformation
include
cytochrome
P450,
acetyltransferase,
glycosyltransferases,
methyltransferase.
Density
functional
theory
calculations
structural
differences
affecting
sites
intermediates.
disrupted
lipid
metabolism,
altered
carbohydrate
amino
acid
pathways,
highlighting
their
selective
effects
on
metabolism.
Our
data
help
understand
sulfonamide
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
Mushroom
production
using
agroforestry
biowaste
is
a
great
green
cycling
agriculture
alternative.
Therefore,
the
current
study
explored
Livestock-Crop-Mushroom
(LCM)
circular
model,
starting
with
co-composting
of
straw
and
cow
manure
as
a'St'
biofertilizer
further
used
for
mushroom
cultivation
that
ultimately
produced
a'StM'
biofertilizer.
The
two
biofertilizers
were
tested
their
impacts
on
plant
growth
potential
microbial
risks.
results
show
significant
oats
stimulated
by
biofertiliser
use.
Both'St'
and'StM'
increased
biomass,
while
latter,
crude
protein
content
(+5.1%)
root
biomass
also
higher.
Reduced
abundances
resistome
genes
(30%)
pathogens
(25%)
observed
during
oat
growth.
Further,
metagenomics
analysis
indicated
reduction
in
antibiotic-resistance
-20%
soils
treated
by'St'
-46%
in'StM'
treatment.
The'StM'
had
three-fold
stronger
inhibitory
effect
rhizosphere
soil
than'St'.
Moreover,
compared
to'St','StM'
suppressed
seeds
stems,
specific
beneficial
biomarker
microbes
different
parts.
Overall,
antibiotic
resistance
gene
related
to
oxytetracycline
decreased
more
than
LCM
system.
This
demonstrates
substantial
scalability
system
within
agricultural
domain.
