Probiotic Intervention Alleviates Helicobacter pylori-induced Intestinal Inflammation by Sustaining Intestinal Homeostasis DOI Creative Commons

Shiying Wu,

Fangtong Wei,

Yongqiang Chen

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Abstract Helicobacter pylori (H. pylori) infection poses significant risks for gastric cancer and intestinal inflammation, yet effective prevention strategies inflammation remain elusive. Here, we aimed to investigate the protective effects underlying mechanisms of Lactiplantibacillus plantarum ZJ316 (L. ZJ316) in a mouse model H. pylori-induced inflammation. Our results demonstrated that treatment with L. effectively reduced tissue damage upregulated expression tight junction proteins such as Zonula occludens-1 (ZO-1), Occludin, Claudin-1, while decreased pro-inflammatory cytokines interleukin-1β (IL-1β), interferon γ (IFN-γ), tumor necrosis factor α (TNF-α). Additionally, intaking relative abundance pathogenic bacteria Staphylococcus Desulfovibrio by 69%, 42%, respectively, enhancing beneficial including Ligilactobacillus, Akkermansia, Lactobacillus associated short-chain fatty acids (SCFAs) synthesis, 88%, 85%, 16%, respectively. Gas chromatography–mass spectrometry (GC-MS) analysis confirmed reversed declines SCFA levels. In vitro, inhibited IκBα/NF-κB pathway, thereby reducing TNF-α IL-8 production HT-29 cells following infection. These findings collectively suggest ameliorates gut barrier function, improving flora structure, increasing levels, mitigating through NF-κB pathway inhibition, offering promise therapeutic development.

Язык: Английский

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies DOI Creative Commons

Neelakanta Sarvashiva Kiran,

Chandrashekar Yashaswini,

Rahul Maheshwari

и другие.

ACS Pharmacology & Translational Science, Год журнала: 2024, Номер 7(4), С. 967 - 990

Опубликована: Март 19, 2024

Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized effective disease management. Identification key driver mutations molecular profiling have deepened our comprehension genetic alterations in cancer, facilitating targeted therapy immunotherapy selection. Biomarkers such as microsatellite instability (MSI) DNA mismatch repair deficiency (dMMR) guide decisions, opening avenues for immunotherapy. Emerging liquid biopsies, artificial intelligence, machine learning promise to revolutionize early detection, monitoring, selection precision medicine. Despite these advancements, ethical regulatory challenges, including equitable access data privacy, emphasize importance responsible implementation. The dynamic nature with its tumor heterogeneity clonal evolution, underscores necessity adaptive strategies. future lies potential enhance patient care, clinical outcomes, understanding this intricate disease, marked by ongoing evolution field. current reviews focus on providing in-depth knowledge various diverse approaches utilized against at both biochemical levels.

Язык: Английский

Процитировано

19
Effects of the plastic additive 2,4-di-tert-butylphenol on intestinal microbiota of zebrafish DOI
Yongmeng Yang,

Chen Yan,

Aifeng Li

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 469, С. 133987 - 133987

Опубликована: Март 8, 2024

Язык: Английский

Процитировано

9
Mechanisms of eco-corona effects on micro(nano)plastics in marine medaka: Insights into translocation, immunity, and energy metabolism DOI
Ling Liu,

Yuqing Ma,

Yanan Xu

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136236 - 136236

Опубликована: Окт. 21, 2024

Язык: Английский

Процитировано

4
Lactiplantibacillus plantarum ZJ316 Alleviates Helicobacter pylori-Induced Intestinal Inflammation by Sustaining Intestinal Homeostasis DOI

Shiying Wu,

Fangtong Wei,

Yongqiang Chen

и другие.

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Язык: Английский

Процитировано

0
Effects of okadaic acid on Pyropia yezoensis: Evidence from growth, photosynthesis, oxidative stress and transcriptome analysis DOI
Ruolin Wu, Jiangbing Qiu,

Xianghai Tang

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер 491, С. 137902 - 137902

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

0
RuSiNPs@N,S-GQDs as self-enhanced anodic electrochemiluminescent immunobeacons for the highly sensitive quantitation of okadaic acid in shellfish DOI

Silun Li,

Jiawei Peng,

Xueying Lin

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Abstract The accurate and rapid assessment of okadaic acid (OA) levels in shellfish is paramount importance for ensuring seafood safety. In this study, a competitive electrochemiluminescence (ECL) immunosensor was proposed the precise quantitation OA, utilizing novel self-enhanced solid-state ECL marker. Graphene quantum dots doped with nitrogen sulfur (N,S-GQDs) were synthesized through electrolysis graphite 3-(N-morpholine) propane sulfonic (MOPS) solution. Intriguingly, these N,S-GQDs exhibited exceptional co-reactant properties, significantly enhancing anodic performance Ru(bpy)32+ phosphate-buffered saline Following functionalization Ru(bpy)32+-doped silica nanoparticles (RuSiNPs) poly(diallyldimethylammonium) chloride (PDDA), we achieved well-dispersed assembly on exterior RuSiNPs electrostatic interactions. Importantly, core-shell structure RuSiNPs@N,S-GQDs efficiently encapsulated both luminophore co-reactant, facilitating improved electron transfer rates, shorter interaction distances, reduced energy loss during light emission. Consequently, displayed enhanced properties compared to bare RuSiNPs. Leveraging "bright" beacon, our demonstrated remarkable analytical performance, yielding low half maximal inhibitory concentration (IC50) 0.14 ng mL− 1, an extensive linear range spanning 0.003-40 impressively limit detection 1 fg 1 OA determination.

Язык: Английский

Процитировано

0
Short-term exposure to okadaic acid induces behavioral and physiological responses in sea urchin (Strongylocentrotus intermedius) DOI

Hongce Song,

Meiyun Dong,

Lei Wei

и другие.

Marine Environmental Research, Год журнала: 2024, Номер 202, С. 106823 - 106823

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0
RuSiNPs@N,S-GQDs as self-enhanced anodic electrochemiluminescent immunobeacons for the highly sensitive quantitation of okadaic acid in shellfish DOI

Silun Li,

Jiawei Peng,

Xueying Lin

и другие.

Microchimica Acta, Год журнала: 2024, Номер 191(12)

Опубликована: Ноя. 12, 2024

Язык: Английский

Процитировано

0
Probiotic Intervention Alleviates Helicobacter pylori-induced Intestinal Inflammation by Sustaining Intestinal Homeostasis DOI Creative Commons

Shiying Wu,

Fangtong Wei,

Yongqiang Chen

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Abstract Helicobacter pylori (H. pylori) infection poses significant risks for gastric cancer and intestinal inflammation, yet effective prevention strategies inflammation remain elusive. Here, we aimed to investigate the protective effects underlying mechanisms of Lactiplantibacillus plantarum ZJ316 (L. ZJ316) in a mouse model H. pylori-induced inflammation. Our results demonstrated that treatment with L. effectively reduced tissue damage upregulated expression tight junction proteins such as Zonula occludens-1 (ZO-1), Occludin, Claudin-1, while decreased pro-inflammatory cytokines interleukin-1β (IL-1β), interferon γ (IFN-γ), tumor necrosis factor α (TNF-α). Additionally, intaking relative abundance pathogenic bacteria Staphylococcus Desulfovibrio by 69%, 42%, respectively, enhancing beneficial including Ligilactobacillus, Akkermansia, Lactobacillus associated short-chain fatty acids (SCFAs) synthesis, 88%, 85%, 16%, respectively. Gas chromatography–mass spectrometry (GC-MS) analysis confirmed reversed declines SCFA levels. In vitro, inhibited IκBα/NF-κB pathway, thereby reducing TNF-α IL-8 production HT-29 cells following infection. These findings collectively suggest ameliorates gut barrier function, improving flora structure, increasing levels, mitigating through NF-κB pathway inhibition, offering promise therapeutic development.

Язык: Английский

Процитировано

0