Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 471, С. 134356 - 134356

Опубликована: Апрель 19, 2024

Язык: Английский

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Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 472, С. 134598 - 134598

Опубликована: Май 13, 2024

Язык: Английский

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Occurrence of Multiple Classes of Emerging Synthetic Antioxidants, Including p-Phenylenediamines, Diphenylamines, Naphthylamines, Macromolecular Hindered Phenols, and Organophosphites, in Human Milk: Implications for Infant Exposure

Environmental Science & Technology Letters, Год журнала: 2024, Номер 11(3), С. 259 - 265

Опубликована: Фев. 26, 2024

Synthetic antioxidants (AOs) have received increasing attention in recent years due to their environmental ubiquity. However, lactational exposure these emerging contaminants of current concern remains unknown. In this study, 21 amine antioxidants, 18 macromolecular hindered phenol 3 organophosphite and 2 p-phenylenediamine-derived quinones (PPD-Qs) were integrated into a dedicated screening human milk from South China. Among all 42 target AOs, 19 detected, but no PPD-Qs detected any the samples. Eight including N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), frequently more than half The summed concentrations detectable AOs ranged 133 7,560 pg/mL, with median 713 pg/mL. Significant correlations observed among antioxidants. preliminary risk assessment revealed that under high scenario, overall daily intake identified through breastfeeding might pose non-negligible health newborns. This study is first attempt comprehensively identify wide range prevalent milk. findings call for urgent infant widely used less well evaluated chemicals possible increased accumulative future.

Язык: Английский

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A nation-wide study for the occurrence of PPD antioxidants and 6PPD-quinone in road dusts of China

The Science of The Total Environment, Год журнала: 2024, Номер 922, С. 171393 - 171393

Опубликована: Фев. 29, 2024

Язык: Английский

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Potential human health risk of the emerging environmental contaminant 6-PPD quinone

The Science of The Total Environment, Год журнала: 2024, Номер 949, С. 175057 - 175057

Опубликована: Июль 26, 2024

Язык: Английский

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Toxicity of substituted p-phenylenediamine antioxidants and their derived novel quinones on aquatic bacterium: Acute effects and mechanistic insights

Journal of Hazardous Materials, Год журнала: 2024, Номер 469, С. 133900 - 133900

Опубликована: Фев. 27, 2024

Язык: Английский

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6-PPD quinone causes alteration in ubiquinone-mediated complex III associated with toxicity on mitochondrial function and longevity in Caenorhabditis elegans

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 116571 - 116571

Опубликована: Апрель 1, 2025

Язык: Английский

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P-phenylenediamine antioxidants and their quinone derivatives: A review of their environmental occurrence, accessibility, potential toxicity, and human exposure

The Science of The Total Environment, Год журнала: 2024, Номер 948, С. 174449 - 174449

Опубликована: Июль 3, 2024

Язык: Английский

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6PPDQ induces cardiomyocyte senescence via AhR/ROS-mediated autophagic flux blockage

Environmental Pollution, Год журнала: 2024, Номер 349, С. 123872 - 123872

Опубликована: Апрель 9, 2024

Язык: Английский

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Environmentally Relevant Concentrations of S-6PPD-Quinone Caused More Serious Hepatotoxicity Than R-Enantiomer and Racemate in Oncorhynchus mykiss

Environmental Science & Technology, Год журнала: 2024, Номер 58(40), С. 17617 - 17628

Опубликована: Сен. 23, 2024

6PPD-quinone (6PPD-Q) is frequently detected in various environmental media, and the environmentally relevant concentrations can be fatal to

Язык: Английский

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