Environmental Science Nano,
Год журнала:
2024,
Номер
11(9), С. 3843 - 3855
Опубликована: Янв. 1, 2024
High
concentration
of
nanoplastics
inhibited
serum
hormone
levels,
glucose
metabolism
related
enzyme
activity
and
gene
expression.
Nanoplastic
exposure
may
have
a
negative
effect
on
metabolites
via
inhibition
the
pentose
phosphate
pathway.
Journal of Applied Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
ABSTRACT
In
the
environment,
nanoplastics
(NPs)
have
been
shown
to
adversely
impact
reproductive
health,
yet
research
on
their
effects
during
early
pregnancy
is
scarce.
This
study
investigated
of
NPs
endometrial
decidualization
in
pregnant
mice
and
fertility.
Female
were
administered
polystyrene
(PS‐NPs)
orally
for
90
days
before
pregnancy.
Our
findings
indicated
that
PS‐NPs
exposure
decreased
live
birth
rate
neonatal
crown‐rump
length.
Decreased
embryo
implantation
sites
uterine
wet
weight
observed
post
exposure.
Histological
examination
revealed
structural
defects
uteri
a
significant
reduction
follicular
count
across
all
stages
PS‐NPs‐treated
groups.
Serum
levels
estradiol
(E
2
)
progesterone
(P)
elevated,
while
follicle‐stimulating
hormone
(FSH)
luteinizing
(LH)
diminished
post‐exposure.
Additionally,
upregulated
expression
marker
HOXA10
decidua.
conclusion,
our
results
suggest
may
disrupt
disruption
likely
due
perturbation
hormonal
balance
within
hypothalamic–pituitary–ovary
including
FSH,
LH,
E
,
P
levels.
These
alterations
arrest
development,
consequently
leading
detrimental
outcomes
compromised
conditions.
provided
new
perspective
understanding
possible
microplastics
female
Sustainability,
Год журнала:
2024,
Номер
16(10), С. 4066 - 4066
Опубликована: Май 13, 2024
In
recent
years,
the
adverse
effects
of
nanoplastics
(NPs)
and
pyriproxyfen
on
aquatic
environments
have
attracted
widespread
attention.
However,
research
their
combined
exposure
to
organisms
could
be
more
extensive.
This
work
evaluated
acute
chronic
toxic
polystyrene
NPs
(PS-NPs)
Daphnia
magna
(D.
magna)
under
conditions.
The
addition
PS-NPs
within
24
h
reduced
toxicity
D.
magna,
resulting
in
an
increase
24-h
EC50
values
from
0.24
mg/L
0.35,
0.51,
1.26
mg/L,
respectively
when
1,
5,
10
were
added.
Compared
with
PS-NPs,
significantly
disturbed
growth
reproduction
test
at
21
days.
caused
by
alleviated
co-exposed.
addition,
it
was
observed
that
resulted
less
uptake
using
a
time-gated
imaging
technique.
These
findings
provide
new
insight
into
is
important
understand
complex
pollutants
systems.
Moreover,
has
provided
scientific
basis
for
environmental
protection
sustainable
development.