
Heliyon, Год журнала: 2024, Номер 11(1), С. e41298 - e41298
Опубликована: Дек. 18, 2024
Язык: Английский
Heliyon, Год журнала: 2024, Номер 11(1), С. e41298 - e41298
Опубликована: Дек. 18, 2024
Язык: Английский
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(5), С. 4186 - 4202
Опубликована: Апрель 30, 2024
As environmental plastic waste degrades, it creates an abundance of diverse microplastic particles. Consequently, microplastics contaminate drinking water and many staple food products, meaning the oral ingestion is important exposure route for human population. Microplastics have long been considered inert, however their ability to promote microbial dysbiosis as well gut inflammation dysfunction suggests they are more noxious than first thought. More alarmingly, there evidence permeating from throughout body, with adverse effects on immune nervous systems. Coupled now-accepted role gut-brain axis in neurodegeneration, these findings support hypothesis that this ubiquitous pollutant contributing rising incidence neurodegenerative diseases, like Alzheimer’s disease Parkinson’s disease. This comprehensive narrative review explores consequences gut-brain-axis by considering current gastrointestinal uptake disruption, activation, translocation neurological effects. now a permanent feature global environment, understanding gut, brain, whole body will facilitate critical further research inform policy changes aimed at reducing any consequences.
Язык: Английский
Процитировано
10Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 116925 - 116925
Опубликована: Авг. 27, 2024
Microplastic (MP) are an emerging environmental pollutant, which has toxic effects on organisms, and it received extensive attention currently. Studying the transcriptomic metabolic responses of mice to nanoplastic-contaminated water is critical for understanding molecular-level toxicity nanoplastics (NPs), but there few studies this topic. To analyze different concentrations polystyrene (PS) at transcriptome metabolism spleens study molecular toxicity. Here, testing histopathology spleen female was performed after drinking containing 0.1 μm PS-NPs (1 mg/mL 50 mg/mL) 49 days, respectively. The tissue samples were subjected metabolome sequencing. Four differentially expressed genes randomly chosen qRT-PCR confirm correctness Common Kyoto encyclopedia genomes (KEGG) pathway analysis showed that a large number differential metabolites mainly focused immune, inflammation, neurodegenerative disease, cardiovascular nervous, etc. in organism systems module; lipid, amino acid, taurine hypotaurine metabolisms, signaling translation, molecules interaction, neuroactive ligand-receptor information processing. results levels confirmed immune system affected contaminated with nanoplastics.
Язык: Английский
Процитировано
7Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137170 - 137170
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
0International Journal of Biological Macromolecules, Год журнала: 2025, Номер 302, С. 140531 - 140531
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
0International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1222 - 1222
Опубликована: Янв. 30, 2025
Alzheimer’s disease (AD) is one of the most common and severe forms dementia neurodegenerative disease. As life expectancy increases in line with developments medicine, elderly population projected to increase next few decades; therefore, an prevalence some diseases, such as AD, also expected. a result, until radical treatment becomes available, AD expected be more frequently recorded top causes death worldwide. Given current lack cure for only treatments available being ones that alleviate major symptoms, identification contributing factors influence incidence crucial. In this context, genetic and/or epigenetic factors, mainly environmental, disease-related, dietary, or combinations/interactions these are assessed. review, we conducted literature search focusing on environmental air pollution, toxic elements, pesticides, infectious agents, well dietary including various diets, vitamin D deficiency, social (e.g., tobacco alcohol use), variables affected by both behavior gut microbiota. We evaluated studies beneficial effects antibiotics Mediterranean-DASH Intervention Neurodegenerative Delay (MIND) Mediterranean diets.
Язык: Английский
Процитировано
0F1000Research, Год журнала: 2025, Номер 14, С. 284 - 284
Опубликована: Март 12, 2025
Язык: Английский
Процитировано
0Molecules, Год журнала: 2025, Номер 30(7), С. 1432 - 1432
Опубликована: Март 24, 2025
Exposure of organisms to nanoplastics (NPs) is inevitable given their global abundance and environmental persistence. Polyethylene terephthalate (PET) a common plastic used in wide range products, including clothing food beverage packaging. Recent studies suggest that NPs can cross the blood-brain barrier cause potential neurotoxicity. It widely known aggregation amyloid beta (Aβ) peptides brain pathological hallmark Alzheimer’s disease (AD). While impact such as polystyrene (PS) on has been studied, effects PET remain unexplored. In this study, we examined effect different sizes (PET50nm PET140nm) concentrations (0, 10, 50, 100 ppm) fibrillation Aβ1-40. Our results showed presence PET50nm well PET140nm decreased lag phase processes dose- size-dependent manner from 6.7 ± 0.08 h for Aβ absence (Aβcontrol) 3.1 0.03 3.8 0.06 PET140nm. CD spectroscopy significantly impacts structural composition aggregates. A significant rise antiparallel β-sheet content β-turn structure substantial reduction other structures were observed ppm PET50nm. These changes indicate higher (100 promote more rigid uniform peptide Although influence kinetics secondary structure, overall morphology resulting fibrils remains largely unaltered, seen using transmission electron microscopy. Also, local cross-β was not affected by during fibrillation, confirmed 13C solid-state NMR spectroscopy. Overall, these findings show accelerate fibril formation alter fibrils. also accumulation PET-NPs may facilitate progression various neurodegenerative diseases, disease.
Язык: Английский
Процитировано
0Tissue and Cell, Год журнала: 2025, Номер 95, С. 102869 - 102869
Опубликована: Март 28, 2025
Язык: Английский
Процитировано
0Journal of Hazardous Materials, Год журнала: 2025, Номер 492, С. 138074 - 138074
Опубликована: Март 30, 2025
Язык: Английский
Процитировано
0Environment International, Год журнала: 2025, Номер unknown, С. 109441 - 109441
Опубликована: Апрель 1, 2025
Nanoplastics (NPs) have been widely detected in freshwater environments and photodegradation, as well physical chemical breakdown, lead to different surface charges on the plastics. Although evidence literature highlights importance of NPs charge neurotoxicity, substantial gaps mechanistic understanding remain. In current study, zebrafish (Danio rerio) were exposed differentially charged (PS, PS-NH2, PS-COOH) at environmentally relevant concentration (10 μg/L). After full life cycle exposure, potential brain damage, altered metabolism was investigated through light sheet microscopy 3-dimensional imaging, histopathology, Evans blue dye (EBD) extravasation, gene expression, untargeted targeted metabolomics tissue zebrafish. Exposure PS, PS-COOH caused adverse effects performance neurobehaviors, blood-brain-barrier (BBB) permeability, amino acid metabolism, damage BBB mitochondria, overt inflammatory response. PS-NH2 (4.56-fold) (3.59-fold) accumulated reticular formation (RF) male brain, while only RF (6.57-fold) ventral hypothalamus (Hv) (3.08-fold) female brains. Several important biological pathways negatively impacted a charge- gender-specific fashion. This study provides novel insights into underlying toxicity mechanisms model aquatic species, associated environmental risks this group emerging contaminants.
Язык: Английский
Процитировано
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