Simultaneous Detection of Hydrogen Sulfide and Peroxynitrite Dysregulation with a Sequentially Activated Fluorescent Probe in Ulcerative Colitis Disease DOI
Yiliang Chen,

Jiawei Bao,

Qi Wang

и другие.

Analytical Chemistry, Год журнала: 2024, Номер 97(1), С. 721 - 730

Опубликована: Дек. 30, 2024

Ulcerative colitis (UC), often referred to as "green cancer", is a chronic inflammatory bowel disease with an unclear etiology, closely associated the imbalance of hydrogen sulfide (H2S) and peroxynitrite (ONOO-). H2S exhibits anti-inflammatory effects at physiological levels, but excessive concentrations can compromise intestinal barrier, while ONOO- aggravates inflammation. To facilitate molecular-level monitoring these compounds in UC, we developed novel fluorescent probe, BCH, capable simultaneously detecting via distinct channels cascade mode. BCH features rapid response times (H2S: 6 min; ONOO-: 5 min) well-separated emission peaks (120 nm), minimizing spectral overlap. The probe demonstrates high selectivity good detection linearity for (0-500 μM) (0-100 μM), limits 1.6 μM 0.05 ONOO-. has been successfully applied imaging living cells zebrafish, enabling sensitive their fluctuations UC mouse model. These findings indicate that highly promising studying roles assessing biological functions.

Язык: Английский

A fluorescent probe for visualizing peroxynitrite levels during plant growth under abiotic stresses DOI
Shuang Cao, Qijun Sun,

Chenglin Su

и другие.

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137253 - 137253

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
An ingenious chemiluminescence sensing strategy for recalcitrant triphenyl phosphate based on oxidant-free UV-activated MIL-100(Fe) gel system DOI
Huanhuan Zhu, Shuo Chen, Xiao‐Ying Huang

и другие.

Analytica Chimica Acta, Год журнала: 2024, Номер 1330, С. 343274 - 343274

Опубликована: Сен. 21, 2024

Язык: Английский

Процитировано

0
Simultaneous Detection of Hydrogen Sulfide and Peroxynitrite Dysregulation with a Sequentially Activated Fluorescent Probe in Ulcerative Colitis Disease DOI
Yiliang Chen,

Jiawei Bao,

Qi Wang

и другие.

Analytical Chemistry, Год журнала: 2024, Номер 97(1), С. 721 - 730

Опубликована: Дек. 30, 2024

Ulcerative colitis (UC), often referred to as "green cancer", is a chronic inflammatory bowel disease with an unclear etiology, closely associated the imbalance of hydrogen sulfide (H2S) and peroxynitrite (ONOO-). H2S exhibits anti-inflammatory effects at physiological levels, but excessive concentrations can compromise intestinal barrier, while ONOO- aggravates inflammation. To facilitate molecular-level monitoring these compounds in UC, we developed novel fluorescent probe, BCH, capable simultaneously detecting via distinct channels cascade mode. BCH features rapid response times (H2S: 6 min; ONOO-: 5 min) well-separated emission peaks (120 nm), minimizing spectral overlap. The probe demonstrates high selectivity good detection linearity for (0-500 μM) (0-100 μM), limits 1.6 μM 0.05 ONOO-. has been successfully applied imaging living cells zebrafish, enabling sensitive their fluctuations UC mouse model. These findings indicate that highly promising studying roles assessing biological functions.

Язык: Английский

Процитировано

0