ABSTRACT
Sample
preparation
maintains
a
key
bottleneck
in
the
whole
analytical
procedure.
Solid‐phase
sorbents
(SPSs)
have
garnered
increasing
attention
sample
research
due
to
their
crucial
roles
achieving
high
clean‐up
and
enrichment
efficiency
analysis
of
trace
targets
present
complex
matrices.
Novel
nanoscale
materials
with
improved
characteristics
considerable
interest
across
different
scientific
disciplines
limited
capabilities
traditional
bulk‐scale
materials.
The
purpose
this
review
is
offer
thorough
summary
latest
developments
uses
SPSs
preparing
samples
for
chromatographic
analysis,
focusing
on
years
2020–2024.
techniques
are
examined,
such
as
metal–organic
frameworks
(MOFs),
covalent
organic
(COFs),
carbon
nanoparticles
(CNPs),
molecularly
imprinted
polymers
(MIPs),
metallic
nanomaterials
(MNs).
Examining
pros
cons
extraction
methods,
including
solid‐phase
(SPE),
magnetic
SPE
(MSPE),
flow‐based
(FBA‐SPE),
microextraction
(SPME),
stir‐bar
sorptive
(SBSE),
dispersive
(DSPE),
main
focus.
Furthermore,
article
presents
utilization
technology
isolating
common
contaminants
various
environmental,
biological,
food
specimens.
We
highlight
persistent
challenges
anticipate
future
advancements
applications
novel
SPSs.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 16, 2025
Bioenergetic
therapy
based
on
tumor
glucose
metabolism
is
emerging
as
a
promising
therapeutic
modality.
To
overcome
the
poor
bioavailability
and
toxicity
of
arenobufagin
(ArBu),
MOF-derived
intelligent
nanosystem,
ZIAMH,
was
designed
to
facilitate
energy
deprivation
by
simultaneous
interventions
glycolysis,
OXPHOS
TCA
cycle.
Herein,
zeolitic
imidazolate
framework-8
loaded
with
ArBu
indocyanine
green,
encapsulated
within
metal-phenolic
networks
for
chemodynamic
hyaluronic
acid
modification
targeting.
ZIAMH
nanoparticles
can
release
in
microenvironment
chemtherapy,
ICG
enables
photothermal
under
near-infrared
laser
irradiation.
In
vitro
vivo
mechanism
studies
revealed
that
nanoplatform
downregulated
related
genes,
resulting
reduction
substances
metabolites
tumors.
Additionally,
it
significantly
promoted
cell
apoptosis
upregulating
pro-apoptotic
proteins
such
Bax,
Bax/Bcl-2,
cytochrome
C.
Animal
have
shown
inhibition
efficiency
nanomedicines
three
fold
higher
than
free
drugs.
Therefore,
this
study
provides
new
strategy
metabolism-mediated
bioenergetic
PTT/CDT/CT
combined
Point-of-care
testing
(POCT)
with
multiplexed
capability,
ultrahigh
sensitivity,
affordable
smart
devices,
and
user-friendly
operation
is
critically
needed
for
clinical
diagnostics
food
safety.
This
study
presents
a
deep-learning-assisted
microfluidic
immunoassay
platform
that
uses
smartphone-based
imaging
transcoding
system,
polystyrene
microsphere-based
encoding,
artificial-intelligence-assisted
decoding.
Microspheres
of
varying
sizes
act
as
multiprobes,
their
quantities
correlating
to
target
concentrations
after
an
immunoreaction
separation-filtration
within
the
chip.
A
smartphone
intelligent
decoding
software
captures
images
multiprobes
from
chip
performs
classification,
counting,
concentration
calculations.
The
"encoding-decoding"
strategy
integrated
design
allow
these
processes
be
completed
in
simple
steps,
eliminating
need
additional
immunomagnetic
separation.
As
proof
concept,
this
successfully
detected
multiple
respiratory
viruses
antibiotics
various
real
samples
high
sensitivity
30
min,
demonstrating
great
potential
smart,
universal
toolkit
next-generation
POCT
applications.
