The micro(nano)plastics perspective: exploring cancer development and therapy

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Язык: Английский

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Physicochemical Aspects Regarding the Sustainable Conversion of Carwash Slurry as Coverage Admixture for Landfills

Sustainability, Год журнала: 2025, Номер 17(7), С. 2906 - 2906

Опубликована: Март 25, 2025

Transport and vehicle traffic are closely connected with particulate matter (PM) pollution, inducing various fractions into the atmosphere, some of them forming significant deposits on surface car. They washed away during carwash-inducing slurries collecting PM deposits, which characteristic a large area. Crystalline was investigated by XRD coupled polarized optical microscopy (POM). Organic matters were Fourier-Transform Infrared spectrometry (FTIR) gas chromatography, GC-MS. Their microstructure elemental composition SEM-EDX. The crystalline features contain mainly quartz, calcite, clay (muscovite kaolinite) particles having traces goethite lepidocrocite. Slurry particle size distribution established sieving following meshes: 63 µm, 125 250 500 1000 2000 4000 µm. Coarse 250–4000 μm dominated quartz calcite particles. amount decreases size, while muscovite kaolinite increases in finest 0–125 μm. evidenced, firstly, FTIR spectroscopy, revealing mostly CH2; C=O, NH4 bonds that more intense for fine fractions. organic form amorphous crusts associated micro- nano-plastic related to phthalates washing detergents. Atomic Force Microscopy revealed their range between 60 90 nm evidenced nanoparticles within samples. nanofractions adhere bigger humid environments, assuring immobilization reduce hazardous potential. Carwash slurry blending fertile soil ensures proper grass seed germination growth at mixtures up 60% slurry, allowing its sustainable reconversion as landfill dump rehabilitation, preventing emission hazard. Blended compositions containing than have noxious effects seeds, inhibiting germination.

Язык: Английский

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Phthalate exposure induces microRNA-5010/Nrf2-EGR1/GDF15 signaling expression in prostate cancer

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 290, С. 117759 - 117759

Опубликована: Янв. 1, 2025

Phthalate exposure is linked to prostate enlargement through sex hormonal changes and oxidative stress. However, its role action mechanism in cancer remain unclear. This study examined two patient cohorts: 204 patients undergoing biopsy (24 benign 180 malignancies) 85 with confirmed receiving robotic-assisted radical prostatectomy. Urine samples, collected informed consent, were analyzed for urinary DEHP metabolites using HPLC-MS ELISA. Patients exhibited significantly higher MEOHP ΣDEHP metabolite levels than those who underwent (unpaired t-test, p = 0.027 0.039, respectively). MIR-5010 upregulation MIR-205 downregulation observed paired small RNA sequencing analyses (urine pellets of vs. malignant PC3 cells without or treatment), correlating tumor staging the TCGA cohort. Unlike MIR-205, a known suppressor gene cancer, set enrichment analysis revealed that expression was increased Nrf-2 downstream signaling (enriched score: 0.35; 0.17). In vitro assays showed enhanced protein molecules (i.e., SOD2, Heme oxygenase-1, EGR-1) while increasing GDF15 mRNA via EGR-1 regulation dose- time-dependent manner. Furthermore, positively associated MEHP cohort (p 0.0007 0.011, respectively) stress marker 8-OHdG, aggressive VEGF, CCL2/MCP-1 prostatectomy 0.0004, 0.006, 0.0034, These findings suggest phthalate induces EGR-1/GDF-15) microRNA regulation, contributing aggressiveness.

Язык: Английский

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Design of magnetically functionalized hydrogen-bonded organic framework for extraction and enrichment of bisphenols from environmental and human samples

Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157223 - 157223

Опубликована: Ноя. 1, 2024

Язык: Английский

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The protection of bisphenol A-modulated miRNAs and targets by natural products

Environment International, Год журнала: 2025, Номер unknown, С. 109299 - 109299

Опубликована: Янв. 1, 2025

Bisphenol A (BPA) is a ubiquitous environmental pollutant with endocrine-disrupting functions. Identifying protective drugs and exploring the mechanisms against BPA are crucial in healthcare. Natural products exhibiting antioxidant properties considered to be able protect toxicity. Although BPA-modulated targets miRNAs have been individually reported, their connections natural were rarely organized. With help of protein-protein interaction database (STRING), relationship between individual was interconnected provide systemic view. In this review, BPA-downregulated -upregulated classified, interactive network innovatively analyzed using bioinformatic (STRING). also retrieved ingeniously connected targets. Moreover, novel connection BPA-countering integrated into All these targets-associated and/or incorporated STRING network, providing relationships. Overall, target-miRNA-protecting product axis constructed, straightforward direction for effects products.

Язык: Английский

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Association of maternal prenatal phthalate exposure and genetic polymorphisms of metabolic enzyme genes with spontaneous preterm birth: a nested case–control study in China

BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)

Опубликована: Март 17, 2025

The relationship between prenatal phthalate exposure and preterm birth from previous studies has been inconsistent. Meanwhile, few have explored the spontaneous (SPTB) genetic polymorphisms of metabolic enzyme genes or gene-phthalate interactions. aim this study is to evaluate association maternal exposure, polymorphisms, their interactions with SPTB. A total 182 cases SPTB 321 controls full-term delivery were enrolled. Nine metabolites in second trimester urine samples measured by ultra-high performance liquid chromatography coupled tandem mass spectrometry. Genotyping was performed on twenty-six single nucleotide (SNPs) genes, including CYP2C9, CYP2C19, UGT1A7, UGT2B7 UGT2B15 genes. associations estimated multivariable logistic regression analysis. impact gene-gene analyzed via generalized multifactor dimensionality reduction. There no significant differences concentrations two groups. No statistically observed rs4244285 polymorphism CYP2C19 gene associated decreased odds under log-additive (aOR = 0.73, 95% CI: 0.55-0.98) recessive model 0.37, 0.18-0.74). Two SNP loci increased 3.85, 1.31-11.35 for rs3100, aOR rs4148269). However, these not after false discovery rate correction. observed. Maternal present subjects Moreover, there gene-phthalates

Язык: Английский

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Analysis of Phthalate Monoesters and Bisphenols in Human Prostate Cancer Tissue and Urine

Journal of Separation Science, Год журнала: 2025, Номер 48(4)

Опубликована: Апрель 1, 2025

ABSTRACT A growing concern has been raised about human exposure to phthalates and bisphenols, while data is limited regarding the accumulation of these endocrine disrupting chemicals at target tissue. In this study, a novel, simple, sensitive method was successfully developed for simultaneous determination nine phthalate monoesters bisphenols in prostate tissue samples. solid–liquid extraction procedure applied following ultra‐high performance liquid chromatography tandem mass spectrometry analysis. The detection quantification limits were range 4.12 × 10 −3 0.370 ng/g 1.38 1.23 ng/g, respectively. average spiked recoveries varied from 71.4% 102%, with relative standard deviations ≤ 10%. Finally, 76 Four (mono‐ethyl phthalate, mono‐ iso ‐butyl n mono‐benzyl phthalate) detected highest frequency 98.68%, followed by other five (71.05% ∼ 94.74%), bisphenol S (72.37%), (57.89%). Five not any sample. concentrations ranged 1.12 1.86 2 6.08 39.0 respectively, errors ranging 3.25×10 4.64 ng/g. Besides, positive correlation concentration seven could be observed between urine, which indicates that metabolites urine can serve as noninvasive biomarkers evaluate true level This study provides information on association their urinary metabolites, supporting further studies pollutant disease.

Язык: Английский

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Revealing the role of bisphenol A on prostate cancer progression and identifying potential targets: A comprehensive analysis from population cohort to molecular mechanism

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 296, С. 118209 - 118209

Опубликована: Апрель 17, 2025

Язык: Английский

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Association between endocrine disrupting chemicals exposure and the risk of all-cause mortality in individuals with diabetes mellitus or its complications: A prospective cohort study

Environment International, Год журнала: 2025, Номер unknown, С. 109556 - 109556

Опубликована: Май 1, 2025

Язык: Английский

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Establishment and application of a high-performance liquid chromatography-mass spectrometry method for analysis of 15 bisphenols and halogenated phenols in tea

Food Chemistry, Год журнала: 2024, Номер 469, С. 142561 - 142561

Опубликована: Дек. 17, 2024

Язык: Английский

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