Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells DOI Creative Commons

Wenxia Bu,

Cui Ye, Yan Jin

и другие.

Toxics, Год журнала: 2024, Номер 12(12), С. 908 - 908

Опубликована: Дек. 14, 2024

Polystyrene nanoplastics (PS-NPs), a pervasive component of plastic pollution, have emerged as significant environmental and health threat due to their microscopic size bioaccumulative properties. This review systematically explores the biological effects mechanisms PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, disruptions in autophagy. Notably, induce multiple forms cell death, including apoptosis, ferroptosis, necroptosis, pyroptosis, mediated through distinct yet interconnected molecular pathways. The also highlights various factors that influence cytotoxicity PS-NPs, such particle size, surface modifications, co-exposure with other pollutants, protein corona formation. These complex interactions underscore extensive potentially hazardous impacts health. findings presented here emphasize need for continued research underlying PS-NP toxicity development effective strategies mitigating effects, thereby informing regulatory frameworks aimed at minimizing risks.

Язык: Английский

Identification of Microplastics in Human Tear Fluid and Meibum: Implications for Dry Eye Disease Pathogenesis DOI Creative Commons
Jingyi Wang, Huanmin Kang,

Xixuan Huang

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137635 - 137635

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

1
α‐Lipoic Acid Ameliorates Arsenic‐Induced Lipid Disorders by Promoting Peroxisomal β‐Oxidation and Reducing Lipophagy in Chicken Hepatocyte DOI Creative Commons
Yangfei Zhao, Mingyue Guo,

Ting Pei

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

Abstract Liver disease poses a significant threat to global public health, with arsenic (As) recognized as major environmental toxin contributing liver injury. However, the specific mechanisms and protective effects of α‐lipoic acid (LA) remain unclear. Therefore, this study employs network toxicology pharmacology comprehensively analyze hepatotoxic mechanism As hepatoprotective LA, further verifies peroxisomal β‐oxidation lipophagy in process. The analysis results show that induces damage mainly through autophagy, apoptosis, lipid metabolism, oxidative stress, whereas LA exerts its properties by regulating metabolism. Further verifications find inhibits SIRT1 expression, activates P53 Notch pathways, damages mitochondria, β‐oxidation, increases accumulation, enhances liver, while intervention alleviates As‐induced accumulation targeting SIRT1, ameliorating mitochondrial damage, enhancing thereby alleviating damage. This clarifies hepatotoxicity provides theoretical basis for potential agent.

Язык: Английский

Процитировано

0
Low molecular weight protein tyrosine phosphatase: A driver of lipid metabolic remodeling in Caenorhabditis elegans DOI Creative Commons
Lu An,

Bingyu Geng,

Lin An

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141332 - 141332

Опубликована: Фев. 21, 2025

Язык: Английский

Процитировано

0
Unraveling the Impact of Micro- and Nano-sized Polymethyl methacrylate on Gut Microbiota and Liver Lipid Metabolism: Insights from Oral Exposure Studies DOI

Peng Chen Zheng,

Xin Pan, Yi Zhou

и другие.

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126157 - 126157

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
PVC Nanoplastics Impair Cardiac Function via Lysosomal and Mitochondrial Dysfunction DOI
Guoxia Liu,

Qimei Bao,

Chunkai Zhang

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер unknown, С. 151736 - 151736

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells DOI Creative Commons

Wenxia Bu,

Cui Ye, Yan Jin

и другие.

Toxics, Год журнала: 2024, Номер 12(12), С. 908 - 908

Опубликована: Дек. 14, 2024

Polystyrene nanoplastics (PS-NPs), a pervasive component of plastic pollution, have emerged as significant environmental and health threat due to their microscopic size bioaccumulative properties. This review systematically explores the biological effects mechanisms PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, disruptions in autophagy. Notably, induce multiple forms cell death, including apoptosis, ferroptosis, necroptosis, pyroptosis, mediated through distinct yet interconnected molecular pathways. The also highlights various factors that influence cytotoxicity PS-NPs, such particle size, surface modifications, co-exposure with other pollutants, protein corona formation. These complex interactions underscore extensive potentially hazardous impacts health. findings presented here emphasize need for continued research underlying PS-NP toxicity development effective strategies mitigating effects, thereby informing regulatory frameworks aimed at minimizing risks.

Язык: Английский

Процитировано

0