Industrialization drives the gut microbiome and resistome of the Chinese populations
mSystems,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
ABSTRACT
Industrialization
has
driven
lifestyle
changes
in
eastern
and
western
Chinese
populations,
yet
we
have
a
poor
understanding
of
the
dynamic
their
gut
microbiome
resistome
under
industrialization,
which
is
essential
for
scientific
management
public
health.
Here,
this
study
employed
metagenomics
to
analyze
microbiota
1,382
healthy
individuals
from
China,
including
415
region
advanced
industrialization
967
developing
industrialization.
Compared
with
populations
show
significant
increase
interindividual
dissimilarity
microbial
species
composition
metabolic
pathways
but
decrease
intraindividual
functional
diversity.
Furthermore,
our
results
found
significantly
less
abundance
richness
antibiotic
resistance
genes
(ARGs)
alongside
lower
prevalence
unique
core
ARG
subtypes.
For
12
types
shared
between
mean
relative
two
was
notably
higher
while
eight
had
populations.
Based
on
reconstruction
metagenomic
assembled
genomes,
that
Escherichia
coli
genomes
carried
more
virulence
factor
(VFGs)
mobile
genetic
elements
(MGEs)
compared
those
This
large-scale
first
time
revealed
potentially
led
unexpected
alterations
provide
vital
implication
health
may
aid
development
region-specific
strategies
managing
pathogenic
infections.
IMPORTANCE
As
China
experiences
rapid
uneven
its
effect
people’s
bacteria
critical
reveals
how
reshape
risks
related
resistance.
work
provides
crucial
information
help
create
customized
policies
different
regions.
Язык: Английский
Urbanization enhances consumer protist-driven ARGs dissemination in riverine ecosystems
Environment International,
Год журнала:
2024,
Номер
195, С. 109238 - 109238
Опубликована: Дек. 24, 2024
Despite
the
emergence
of
antibiotic
resistance
genes
(ARGs)
and
resistant
bacteria
(ARBs),
how
biological
inter-trophic
interactions,
modulated
by
watershed
urbanization,
shape
resistome
remains
unexplored.
We
collected
water
samples
from
highly
urbanized
(western:
65
%
built
land,
sewage-affected)
lesser-urbanized
(northern:
25
drinking
source)
downstream
tributaries
Jiulong
River
in
southeast
China
over
dry
wet
seasons.
utilized
metagenomic
amplicon
(16S
18S
rDNA)
sequencing
to
investigate
relationships
among
microeukaryotic
algae,
consumer
protists,
bacterial
communities,
resistome.
Metagenomic
results
showed
that
ARG-MGE-carrying
contigs
(mobile
ARGs),
rather
than
ARG-carrying
(non-mobile
exhibited
more
pronounced
discrepancies
between
tributaries.
A
higher
total
abundance
ARGs
a
greater
number
co-shared
pathogen
non-pathogen
were
observed
western
tributary.
Structural
equation
modeling
revealed
protist-bacteria
algae-bacteria
cohesions
predominantly
influenced
northern
tributaries,
respectively.
Additionally,
protists
had
significant
associations
(511
out
634)
with
carrying
mobile
tributary,
while
algae
(73
105)
These
highlight
distinct
driving
factors
urbanization.
Язык: Английский