Journal of Natural Products, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Plant-derived natural products are commonly consumed orally and can be structurally modified by the gut microbiota, potentially altering their biological activity. However, high-throughput studies on microbial metabolism remain limited. This study applied an in vitro screening system for microbiome-derived using liquid chromatography-mass spectrometry to analyze of 200 human successfully annotated 118 metabolized microbiota. For first time, metabolic reactions isorhynchophylline wilforgine intestine were documented. Notably, a substantial increase plasma concentration isocorynoxeine was observed microbiota-colonized rats following administration compared those without colonization, suggesting that dehydrogenation microbiota also occurs vivo. 16S rRNA gene sequencing further revealed increased abundance Klebsiella Escherichia-Shigella administration, these genera may influence its transformation or pharmacological

Язык: Английский