International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(24), С. 15489 - 15489
Опубликована: Дек. 7, 2022
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
the
most
prevalent
chronic
disease,
affecting
approximately
one-quarter
of
global
population,
and
has
become
a
world
public
health
issue.
NAFLD
clinicopathological
syndrome
characterized
by
hepatic
steatosis,
excluding
ethanol
other
definite
damage
factors.
Recent
studies
have
shown
that
development
associated
with
lipid
accumulation,
oxidative
stress,
endoplasmic
reticulum
lipotoxicity.
A
range
natural
products
been
reported
as
regulators
in
vivo
vitro.
This
paper
reviews
pathogenesis
some
to
therapeutic
effects
on
NAFLD.
Our
work
shows
can
be
potential
option
for
Oxidative Medicine and Cellular Longevity,
Год журнала:
2018,
Номер
2018, С. 1 - 14
Опубликована: Янв. 1, 2018
Liver
steatosis
without
alcohol
consumption,
namely,
nonalcoholic
fatty
liver
disease
(NAFLD),
is
a
common
hepatic
condition
that
encompasses
wide
spectrum
of
presentations,
ranging
from
simple
accumulation
triglycerides
in
the
hepatocytes
any
damage
to
inflammation,
necrosis,
ballooning,
and
fibrosis
(namely,
steatohepatitis)
up
severe
eventually
cirrhosis
and/or
hepatocellular
carcinoma.
The
pathophysiology
its
progression
influenced
by
multiple
factors
(environmental
genetics),
“multiple
parallel-hit
model,”
which
oxidative
stress
plays
very
likely
primary
role
as
starting
point
extrahepatic
damage.
aim
this
review
give
comprehensive
insight
on
present
researches
findings
mechanisms
pathogenesis
NAFLD.
With
aim,
we
evaluated
available
data
basic
science
clinical
studies
field,
reviewing
most
recent
works
published
topic.
Journal of Diabetes Research,
Год журнала:
2020,
Номер
2020, С. 1 - 16
Опубликована: Авг. 4, 2020
Nonalcoholic
fatty
liver
disease
(NAFLD)
and
type
2
diabetes
mellitus
(T2DM)
remain
as
one
of
the
most
global
problematic
metabolic
diseases
with
rapidly
increasing
prevalence
incidence.
Epidemiological
studies
noted
that
T2DM
patients
have
by
two-fold
increase
to
develop
NAFLD,
vice
versa.
This
complex
intricate
association
is
supported
mediated
insulin
resistance
(IR).
In
this
review,
we
discuss
NAFLD
immunopathogenesis,
connection
IR
T2DM,
role
screening
noninvasive
tools,
mostly
impact
current
antidiabetic
drugs
on
steatosis
new
potential
therapeutic
targets.
Nature Reviews Endocrinology,
Год журнала:
2021,
Номер
17(3), С. 135 - 149
Опубликована: Янв. 21, 2021
Obesity
and
impaired
metabolic
health
are
established
risk
factors
for
the
non-communicable
diseases
(NCDs)
type
2
diabetes
mellitus,
cardiovascular
disease,
neurodegenerative
diseases,
cancer
nonalcoholic
fatty
liver
otherwise
known
as
associated
disease
(MAFLD).
With
worldwide
spread
of
severe
acute
respiratory
syndrome
coronavirus
(SARS-CoV-2),
obesity
also
emerged
important
determinants
2019
(COVID-19).
Furthermore,
novel
findings
indicate
that
specifically
visceral
characteristics
such
hyperglycaemia,
hypertension
subclinical
inflammation
with
a
high
COVID-19.
In
this
Review,
we
highlight
how
increase
complications
mortality
in
We
summarize
consequences
SARS-CoV-2
infection
organ
function
NCDs.
addition,
discuss
data
indicating
COVID-19
pandemic
could
have
serious
epidemic.
As
both
accelerators
COVID-19,
might
adversely
influence
efficacy
vaccines,
propose
strategies
prevention
treatment
on
clinical
population
level,
particularly
while
is
present.
This
Review
highlights
(COVID-19)
summarizes
function.
there
discussion
implications
pandemic.
Transplantation,
Год журнала:
2018,
Номер
103(1), С. e1 - e13
Опубликована: Окт. 9, 2018
Nonalcoholic
fatty
liver
disease
(NAFLD)
represents
a
growing
cause
of
chronic
injury,
especially
in
western
countries,
where
it
is
becoming
the
most
frequent
indication
for
transplantation.
encompasses
spectrum
diseases
that
from
simple
steatosis
(pure
NAFLD)
can
progress
to
nonalcoholic
steatohepatitis
(NASH),
cirrhosis
and
hepatocellular
carcinoma.
The
pathogenesis
NAFLD
mechanisms
behind
its
progression
NASH
have
been
extensively
studied.
However,
although
processes
determine
fat
accumulation
are
mostly
clear,
associated
with
not
fully
characterized.
In
predisposed
patients,
lipid
promote
lipotoxicity
mitochondrial
dysfunction,
thus
triggering
hepatocyte
death,
inflammation
fibrosis.
specific
role
different
lipids
has
identified
free
acids
as
well
cholesterol
toxic
species.
To
make
picture
more
complex,
involves
pathological
connections
between
several
organs,
including
adipose
tissue
gut,
liver.
"inflamed"
plays
key
release
lipids,
whereas
alterations
gut-liver
axis
mediated
by
dysbiosis,
alteration
intestinal
barrier,
finally
bacterial
translocation,
which
trigger
proinflammatory
profibrogenetic
pathways,
leading
development.
