Abstract
The
“hotness”
or
“coldness”
of
the
tumors
are
determined
by
information
cancer
cells
themselves,
tumor
immune
characteristics,
microenvironment,
and
signaling
mechanisms,
which
key
factors
affecting
patients’
clinical
efficacy.
switch
mechanism
its
corresponding
pathological
characteristics
treatment
strategies
frontier
hot
spot
treatment.
How
to
distinguish
effectively
clarify
causes,
microenvironment
state,
very
important
for
response
efficacy
treatments.
Starting
from
concept
cold
tumor,
this
review
systematically
summarized
molecular
influencing
factors,
therapeutic
“hot
tumors,”
analyzed
immunophenotypes,
pathways,
markers
that
contribute
tumors”
in
details.
Different
“cold
based
on
were
with
drug
targets
proteins
tumors.”
Furthermore,
combines
different
traditional
medicine
modern
medicine,
provide
a
basis
guidance
decision‐making
Ectopic
lymphoid
aggregates,
termed
tertiary
structures
(TLSs),
are
formed
in
numerous
cancer
types,
and,
with
few
exceptions,
their
presence
is
associated
superior
prognosis
and
response
to
immunotherapy.
In
spite
of
presumed
importance,
the
triggers
that
lead
TLS
formation
tissue
contribution
these
intratumoral
immune
responses
remain
incompletely
understood.
Here,
we
discuss
present
knowledge
on
TLSs
cancer,
focusing
(i)
drivers
formation,
(ii)
function
antitumor
response,
(iii)
potential
as
therapeutic
targets
human
cancers.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Янв. 15, 2020
Abstract
Clonal
evolution
of
a
tumor
ecosystem
depends
on
different
selection
pressures
that
are
principally
immune
and
treatment
mediated.
We
integrate
RNA-seq,
DNA
sequencing,
TCR-seq
SNP
array
data
across
multiple
regions
liver
cancer
specimens
to
map
spatio-temporal
interactions
between
cells.
investigate
how
these
reflect
intra-tumor
heterogeneity
(ITH)
by
correlating
regional
neo-epitope
viral
antigen
burden
with
the
adaptive
response.
Regional
expression
passenger
mutations
dominantly
recruits
responses
as
opposed
hepatitis
B
virus
cancer-testis
antigens.
detect
clonal
expansion
system
in
distant
same
tumor.
An
ITH-based
gene
signature
improves
single-biopsy
patient
survival
predictions
an
survey
38,553
single
cells
7
2
patients
further
reveals
cancer.
These
quantify
transcriptomic
ITH
components
HCC
interact
during
evolution.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Авг. 6, 2022
Abstract
Hepatocellular
carcinoma
(HCC)
represents
a
paradigm
of
the
relation
between
tumor
microenvironment
(TME)
and
development.
Here,
we
generate
single-cell
atlas
multicellular
ecosystem
HCC
from
four
tissue
sites.
We
show
enrichment
central
memory
T
cells
(T
CM
)
in
early
tertiary
lymphoid
structures
(E-TLSs)
assess
relationships
chronic
HBV/HCV
infection
cell
infiltration
exhaustion.
find
MMP9
+
macrophages
to
be
terminally
differentiated
tumor-associated
(TAMs)
PPARγ
pivotal
transcription
factor
driving
their
differentiation.
also
characterize
heterogeneous
subpopulations
malignant
hepatocytes
multifaceted
functions
shaping
immune
HCC.
Finally,
identify
seven
microenvironment-based
subtypes
that
can
predict
prognosis
patients.
Collectively,
this
large-scale
deepens
our
understanding
microenvironment,
which
might
facilitate
development
new
therapy
strategies
for
malignancy.
