Tertiary lymphoid structures marker CXCL13 is associated with better survival for patients with advanced-stage bladder cancer treated with immunotherapy

European Journal of Cancer, Год журнала: 2021, Номер 148, С. 181 - 189

Опубликована: Март 19, 2021

Язык: Английский

---

Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies

OncoImmunology, Год журнала: 2021, Номер 10(1)

Опубликована: Янв. 1, 2021

Tertiary lymphoid structures (TLS) are ectopic cellular aggregates that resemble secondary organs in their composition and structural organization. In contrast to organs, TLS not imprinted during embryogenesis but formed non-lymphoid tissues response local inflammation. exhibiting a variable degree of maturation found solid tumors. They composed various immune cell types including dendritic cells antigen-specific B T lymphocytes, together, actively drive the against tumor development progression. This review highlights successive steps leading formation its association with clinical outcomes. We discuss role played by tumor-infiltrating lymphocytes plasma cells, prognostic value tumors immunotherapeutic responses potential for future targeting.

Язык: Английский

---

B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication

Frontiers in Cell and Developmental Biology, Год журнала: 2021, Номер 9

Опубликована: Июнь 7, 2021

The immune system plays a crucial role in cancer development either by fostering tumor growth or destroying cells, which has open new avenues for immunotherapy. It was only over the last decade that of B cells controlling anti-tumor responses milieu begun to be appreciated. and plasma can exert effects through antibody-dependent cell cytotoxicity (ADCC) activation complement cascade, even though their effector functions extend beyond classical humoral immunity. In tissues, found lymphoid aggregates, known as tertiary structures (TLSs), well-organized non-encapsulated composed stromal cells. These reflect process neogenesis occurring peripheral tissues upon long-lasting exposure inflammatory signals. TLS provides an area intense antigen presentation lead optimal T functions, well generation further differentiated antibody-secreting memory Of clinical interest, crosstalk between antigen-experienced exhausted CD8 + within mature recently associated with improved response checkpoint blockade (ICB) melanoma, sarcoma lung cancer. Otherwise, sparsely distributed microenvironment organized immature TLSs were immune-regulatory inhibiting immunity secretion anti-inflammatory cytokines. Such phenotype might arise when interact malignant rather than dendritic Differences spatial distribution likely underlie discrepancies inferred from human samples mouse models. Many fast-growing orthotopic tumors develop cell-rich bulk reduced stroma are devoid TLSs, highlights importance carefully selecting pre-clinical summary, strategies promote formation close proximity favor immunotherapy responses. Here, cellular molecular programs coordinating development, organization will reviewed, focusing on translational relevance

Язык: Английский

---

Predicting Microvascular Invasion in Hepatocellular Carcinoma Using CT-based Radiomics Model

Radiology, Год журнала: 2023, Номер 307(4)

Опубликована: Апрель 25, 2023

Background Prediction of microvascular invasion (MVI) may help determine treatment strategies for hepatocellular carcinoma (HCC). Purpose To develop a radiomics approach predicting MVI status based on preoperative multiphase CT images and to identify MVI-associated differentially expressed genes. Materials Methods Patients with pathologically proven HCC from May 2012 September 2020 were retrospectively included four medical centers. Radiomics features extracted tumors peritumor regions registration or subtraction images. In the training set, these used build five models via logistic regression after feature reduction. The tested using internal external test sets against pathologic reference standard calculate area under receiver operating characteristic curve (AUC). optimal AUC model clinical-radiologic characteristics combined hybrid model. log-rank was in outcome cohort (Kunming center) analyze early recurrence-free survival overall high versus low model-derived score. RNA sequencing data Cancer Image Archive gene expression analysis. Results A total 773 patients (median age, 59 years; IQR, 49–64 633 men) divided into set (n = 334), 142), 141), 121), analysis 35). AUCs models, respectively, 0.76 0.86 0.72 0.84 set. Early (P < .01) .007) can be categorized Differentially genes findings positive involved glucose metabolism. Conclusion showed best performance prediction MVI. © RSNA, 2023 Supplemental material is available this article. See also editorial by Summers issue.

Язык: Английский

---

Hot and cold tumors: Immunological features and the therapeutic strategies

MedComm, Год журнала: 2023, Номер 4(5)

Опубликована: Авг. 26, 2023

Abstract The “hotness” or “coldness” of the tumors are determined by information cancer cells themselves, tumor immune characteristics, microenvironment, and signaling mechanisms, which key factors affecting patients’ clinical efficacy. switch mechanism its corresponding pathological characteristics treatment strategies frontier hot spot treatment. How to distinguish effectively clarify causes, microenvironment state, very important for response efficacy treatments. Starting from concept cold tumor, this review systematically summarized molecular influencing factors, therapeutic “hot tumors,” analyzed immunophenotypes, pathways, markers that contribute tumors” in details. Different “cold based on were with drug targets proteins tumors.” Furthermore, combines different traditional medicine modern medicine, provide a basis guidance decision‐making

Язык: Английский

---