Alimentary Pharmacology & Therapeutics,
Год журнала:
2024,
Номер
60(3), С. 340 - 349
Опубликована: Май 29, 2024
Summary
Backgrounds
and
Aims
Alcohol
use
leads
to
disabilities
deaths
worldwide.
It
not
only
harms
the
liver
but
also
causes
alcohol
disorder
(AUD)
heart
disease.
Additionally,
consumption
contributes
health
disparities
among
different
socio‐economic
groups.
Methods
We
estimated
global
regional
trends
in
burden
of
AUD,
disease,
cardiovascular
disease
from
using
methodology
Global
Burden
Disease
study.
Results
In
2019,
highest
disability‐adjusted
life
years
rate
per
100,000
population
was
due
AUD
(207.31
[95%
Uncertainty
interval
(UI)
163.71–261.66]),
followed
by
alcohol‐associated
(ALD)
(133.31
UI
112.68–156.17]).
The
prevalence
decreased
for
(APC
[annual
percentage
change]
−0.38%)
alcohol‐induced
cardiomyopathy
−1.85%)
increased
ALD
0.44%)
cancer
0.53%).
Although
mortality
0.30%),
rates
other
diseases
decreased.
Between
2010
complications
countries
with
low
low‐middle
sociodemographic
index
(SDI),
contributing
more
significantly
burden.
Conclusion
liver,
has
been
high
increasing
over
past
decade,
particularly
complications.
Lower
SDI
are
this
There
is
a
pressing
need
effective
strategies
address
escalating
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(4), С. 1931 - 1931
Опубликована: Фев. 16, 2021
Insulin-like
Growth
Factor
(IGF)/IGF-1
Receptor
(IGF-1R)
signaling
is
known
to
regulate
stem
cell
pluripotency
and
differentiation
trigger
proliferation,
organ
development,
tissue
regeneration
during
embryonic
development.
Unbalanced
IGF/IGF-1R
can
promote
cancer
proliferation
activate
reprogramming
in
tumor
tissues,
especially
the
liver.
Hepatocellular
carcinoma
(HCC)
one
of
leading
causes
cancer-related
death,
with
a
high
incidence
mortality
rate
Asia.
Most
patients
advanced
HCC
develop
tyrosine
kinase
inhibitor
(TKI)-refractoriness
after
receiving
TKI
treatment.
Dysregulation
may
expression
stemness
that
leads
refractoriness
recurrence.
In
this
review,
we
summarize
evidence
for
dysregulated
hepatitis
B
virus
(HBV)-associated
HCC.
The
regulation
drug
resistance
will
be
highlighted.
Current
clinical
treatments
potential
therapies
targeting
treatment
discussed.
Cancer Medicine,
Год журнала:
2022,
Номер
11(5), С. 1357 - 1370
Опубликована: Янв. 6, 2022
Liver
cancer
is
one
of
the
most
common
cancers
worldwide.
We
aimed
to
report
burden
liver
at
global,
regional,
and
national
levels
in
204
countries
from
1990
2019,
stratified
by
etiology,
sex,
age,
sociodemographic
index
(SDI).Data
mortality,
incidence,
disability-adjusted
life
years
(DALYs)
its
etiology
were
available
Global
Burden
Diseases,
Injuries,
Risk
Factors
(GBD)
Study
2019.
The
trends
assessed
annual
percentage
change.
All
estimates
are
presented
as
numbers
age-standardized
rates
(ASRs)
per
100,000
population,
with
uncertainty
intervals
(UIs).Globally,
484,577
(95%
UI
444,091-525,798)
mortalities,
534,364
(486,550-588,639)
incident
cases,
12,528,422
(11,400,671-13,687,675)
due
occurred
ASRs
5.95
(5.44-6.44),
6.51
(5.95-7.16),
151.08
(137.53-164.8)
population
for
incidences,
DALYs,
respectively.
From
increased,
whereas
decreased.
Hepatitis
B
C
major
causes
mortality.
mortality
2019
increased
peaking
65-69
70-74
age
group
males
females,
respectively,
number
was
higher
than
females.
Generally,
there
nonlinear
associations
between
ASR
SDIs
values
regional
levels.
China
had
highest
Mongolia
has
2019.Liver
remains
a
public
health
issue
worldwide,
but
etiological
geographical
variations
exist.
It
necessary
increase
awareness
regarding
cancer,
etiologies
importance
early
detection,
diagnosis
treatment.
Microorganisms,
Год журнала:
2022,
Номер
10(2), С. 288 - 288
Опубликована: Янв. 26, 2022
Over
the
past
decade,
scientific
evidence
for
properties,
functions,
and
beneficial
effects
of
probiotics
humans
has
continued
to
accumulate.
Interest
in
use
increased
tremendously.
Among
various
microorganisms,
using
bacteria
have
been
widely
studied
commercialized,
and,
among
them,
Lactobacillus
is
representative.
This
genus
contains
about
300
species
(recently
differentiated
into
23
genera)
countless
strains
reported.
They
improved
a
wide
range
diseases
including
liver
disease,
gastrointestinal
diseases,
respiratory
autoimmune
diseases.
Here,
we
intend
discuss
depth
as
representative
probiotic
chronic
Alimentary Pharmacology & Therapeutics,
Год журнала:
2024,
Номер
60(3), С. 340 - 349
Опубликована: Май 29, 2024
Summary
Backgrounds
and
Aims
Alcohol
use
leads
to
disabilities
deaths
worldwide.
It
not
only
harms
the
liver
but
also
causes
alcohol
disorder
(AUD)
heart
disease.
Additionally,
consumption
contributes
health
disparities
among
different
socio‐economic
groups.
Methods
We
estimated
global
regional
trends
in
burden
of
AUD,
disease,
cardiovascular
disease
from
using
methodology
Global
Burden
Disease
study.
Results
In
2019,
highest
disability‐adjusted
life
years
rate
per
100,000
population
was
due
AUD
(207.31
[95%
Uncertainty
interval
(UI)
163.71–261.66]),
followed
by
alcohol‐associated
(ALD)
(133.31
UI
112.68–156.17]).
The
prevalence
decreased
for
(APC
[annual
percentage
change]
−0.38%)
alcohol‐induced
cardiomyopathy
−1.85%)
increased
ALD
0.44%)
cancer
0.53%).
Although
mortality
0.30%),
rates
other
diseases
decreased.
Between
2010
complications
countries
with
low
low‐middle
sociodemographic
index
(SDI),
contributing
more
significantly
burden.
Conclusion
liver,
has
been
high
increasing
over
past
decade,
particularly
complications.
Lower
SDI
are
this
There
is
a
pressing
need
effective
strategies
address
escalating
