The mechanism study of quercetin isolated from Zanthoxylum bungeanum maxim. inhibiting ferroptosis and alleviating MAFLD through p38 MAPK/ERK signaling pathway based on lipidomics and transcriptomics DOI Creative Commons
Yan Chen,

Fajian Ren,

Nannan Yang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 31, 2025

As a resource with variety of medicinal and edible values, Zanthoxylum bungeanum Maxim has been found to improve high-fat diet-induced metabolic-associated fatty liver disease (MAFLD). The aim this study was predict the main active metabolites in Z. Maxim. Based on network analysis, explore validate their potential mechanisms action through lipidomics transcriptomic techniques. MAFLD mouse model cell were established evaluate effect components MAFLD. Serum biochemical indexes, pathological staining observation, lipid group transcriptome used verify mechanism Quercetin can regulate mice Glycerophospholipid metabolic pathway, thereby improving accumulation injury. At same time, quercetin also by reducing oleic acid-induced HepG2 cells, inhibit ferroptosis p38 MAPK/ERK signaling alleviating progression isolated from ameliorative effects MAFLD, probably mainly affecting pathways MAPK pathways.

Язык: Английский

The mechanism study of quercetin isolated from Zanthoxylum bungeanum maxim. inhibiting ferroptosis and alleviating MAFLD through p38 MAPK/ERK signaling pathway based on lipidomics and transcriptomics DOI Creative Commons
Yan Chen,

Fajian Ren,

Nannan Yang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 31, 2025

As a resource with variety of medicinal and edible values, Zanthoxylum bungeanum Maxim has been found to improve high-fat diet-induced metabolic-associated fatty liver disease (MAFLD). The aim this study was predict the main active metabolites in Z. Maxim. Based on network analysis, explore validate their potential mechanisms action through lipidomics transcriptomic techniques. MAFLD mouse model cell were established evaluate effect components MAFLD. Serum biochemical indexes, pathological staining observation, lipid group transcriptome used verify mechanism Quercetin can regulate mice Glycerophospholipid metabolic pathway, thereby improving accumulation injury. At same time, quercetin also by reducing oleic acid-induced HepG2 cells, inhibit ferroptosis p38 MAPK/ERK signaling alleviating progression isolated from ameliorative effects MAFLD, probably mainly affecting pathways MAPK pathways.

Язык: Английский

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