Threats of per- and poly-fluoroalkyl pollutants to susceptible populations

The Science of The Total Environment, Год журнала: 2024, Номер 921, С. 171188 - 171188

Опубликована: Фев. 22, 2024

Язык: Английский

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Association of per- and polyfluoroalkyl substances with hepatic steatosis and metabolic dysfunction-associated fatty liver disease among patients with acute coronary syndrome

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 264, С. 115473 - 115473

Опубликована: Сен. 16, 2023

Etiology of hepatic steatosis and metabolic dysfunction-associated fatty liver disease (MAFLD) among acute coronary syndrome (ACS) remains unclear. Existing studies suggested the potential role per- polyfluoroalkyl substances (PFAS) in comorbidity ACS patients. Therefore, we conducted a cross-sectional study based on inpatients to assess associations plasma PFAS congeners mixtures with MAFLD. This included 546 newly diagnosed Twelve were quantified using ultra-high-performance liquid chromatography-tandem mass spectrometry. Hepatic was defined by index (HSI). MAFLD as combination risk factor calculation abnormalities. Generalized linear model used examine HSI Adaptive elastic net (AENET) further for selection. Mixture effects also assessed Bayesian kernel machine regression (BKMR). Congeners analysis observed significant greater percent change each doubling PFOS (1.82%, 95% CI: 0.87%, 2.77%), PFHxS (1.17%, 0.46%, 1.89%) total (1.84%, 0.56%, 3.14%). Moreover, (OR=1.42, 1.13, 1.81), (OR=1.31, 1.09, 1.59) (OR=1.43, 1.06, 1.94) associated increased In AENET regression, only presented positive HSI. indicated between is first demonstrate patients, which provides hypothesis into mechanisms behind well tertiary prevention ACS.

Язык: Английский

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Investigating fatty liver disease-associated adverse outcome pathways of perfluorooctane sulfonate using a systems toxicology approach

Food and Chemical Toxicology, Год журнала: 2023, Номер 176, С. 113781 - 113781

Опубликована: Апрель 12, 2023

Язык: Английский

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Exposure to per- and polyfluoroalkyl substances and high-throughput proteomics in Hispanic youth

Environment International, Год журнала: 2024, Номер 186, С. 108601 - 108601

Опубликована: Март 23, 2024

Strong epidemiological evidence shows positive associations between exposure to per- and polyfluoroalkyl substances (PFAS) adverse cardiometabolic outcomes (e.g., diabetes, hypertension, dyslipidemia). However, the underlying cardiometabolic-relevant biological activities of PFAS in humans remain largely unclear. We evaluated with high-throughput proteomics Hispanic youth. included 312 overweight/obese adolescents from Study Latino Adolescents at Risk (SOLAR) 2001 2012, along 137 young adults Metabolic Asthma Incidence Research (Meta-AIR) 2014 2018. Plasma (i.e., PFOS, PFOA, PFHxS, PFHpS, PFNA) were quantified using liquid-chromatography high-resolution mass spectrometry. proteins (n = 334) measured utilizing proximity extension assay an Olink Explore Cardiometabolic Panel I. conducted linear regression covariate adjustment identify PFAS-associated proteins. Ingenuity Pathway Analysis, protein-protein interaction network analysis, protein annotation used investigate alterations functions clusters. Results after adjusting for multiple comparisons showed 13 significant SOLAR six Meta-AIR, sharing similar inflammation, immunity, oxidative stress. In SOLAR, PFNA demonstrated largest number proteins, including ACP5, CLEC1A, HMOX1, LRP11, MCAM, SPARCL1, SSC5D. After considering mixture effect PFAS, only SSC5D remained significant. mixtures GDF15 IL6. Exploratory analysis findings. Specifically, pathway PFOA- PFNA-associated activation immune-related pathways, inflammatory response. PFHxS-associated dendric cell maturation was found. Moreover, associated common clusters immunoregulatory interactions JAK-STAT signaling both cohorts. broad proteomic profiles linked pro-inflammation immunoregulation. The these provide insight into potential molecular mechanisms toxicity.

Язык: Английский

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Exposure to perfluoroalkyl substances and longitudinal changes in bone mineral density in adolescents and young adults: A multi-cohort study

Environmental Research, Год журнала: 2023, Номер 244, С. 117611 - 117611

Опубликована: Дек. 6, 2023

Per- and polyfluoroalkyl substances (PFAS) may impair bone development in adolescence, which impacts life-long health. No previous studies have examined prospective associations of individual PFAS their mixture with mineral density (BMD) changes Hispanic young persons, a population at high risk osteoporosis adulthood.

Язык: Английский

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