Anti-inflammatory agents design via the fragment hybrid strategy in the discovery of compound c1 for treating ALI and UC

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 289, С. 117431 - 117431

Опубликована: Фев. 25, 2025

Язык: Английский

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Primary biliary cholangitis: Insights into genetic susceptibility and systemic manifestations

European Journal of Inflammation, Год журнала: 2025, Номер 23

Опубликована: Март 1, 2025

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by damage to small intrahepatic bile ducts. The etiology and pathogenesis of PBC remain unknown. It often considered be related an immunological disorder induced genetics environmental factors. Antimitochondrial antibodies (AMAs) along with specific antinuclear such as gp210 Sp100 are markers the disease. Middle-aged elderly women main patients. clinical manifestations non-specific, which presents fatigue skin itching usually. However, patients gradually develop cholestasis fibrosis, eventually dying progressed cirrhosis failure. Currently, ursodeoxycholic acid (UDCA) treatment choice, recommended for all may coexist other disorders that arise from multiple systems, inflammatory bowel (IBD), Sjögren’s syndrome (SS) type 1 diabetes mellitus (T1DM). causal relationship between extrahepatic diseases (EHAIDs) unclear. This article summarizes new developments in study primary aims provide reference scientific workers field research on this

Язык: Английский

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Risk of colon polyps and colorectal cancer in primary biliary cholangitis, a population-based retrospective cohort study in Taiwan

Journal of the Formosan Medical Association, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Bile acids are carcinogens causing mutations leading to colorectal cancer (CRC). Higher total bile acid concentrations in the serum of patients with primary biliary cholangitis (PBC), compared healthy controls, have been reported previous studies. However, association between PBC and risk for CRC remains controversial. We investigated development colonic polyps overall this study. The study enrolled 1,936,512 individuals from Longitudinal Health Insurance Database spanning 2000 2017 cohort analysis. Individuals assigned ICD-9-CM ICD-10-CM codes representing were incorporated. A 1:4 control was randomly selected. After adjusting factors using Cox regression analysis, we calculated hazard ratios developing colon general population. Within cohort, consisting 2024 meeting inclusion criteria, 199 developed or CRC. In contrast, among 8096 comparison 650 cases observed during 17-year-follow-up period. According adjusted ratio indicated that 1.678 times higher group group. This population-based retrospective identified a 1.68-fold increased PBC, suggesting potential neoplasia. Further research is warranted evaluate role endoscopic surveillance PBC.

Язык: Английский

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Assessing the causal relationship between metabolic biomarkers and coronary artery disease by Mendelian randomization studies

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Авг. 16, 2024

The development of coronary artery disease (CAD) is significantly affected by impaired endocrine and metabolic status. Under this circumstance, improved prevention treatment CAD may result from knowing the connection between metabolites CAD. This study aims to delve into causal relationship human biomarkers using two-sample Mendelian randomization (MR). Utilizing bidirectional MR analysis, we assessed correlation 1400 blood CAD, data CLSA, encompassing 8299 participants. Metabolite analysis identified 1091 plasma 309 ratios as instrumental variables. To evaluate link analyzed three datasets: ebi-a-GCST005195 (547,261 European & East Asian samples), bbj-a-159 (29,319 cases 183,134 controls), ebi-a-GCST005194 (296,525 samples). estimate links, utilized IVW method. conduct sensitivity used MR-Egger, Weighted Median, MR-PRESSO. Additionally, employed MR-Egger interception Cochran's Q statistic assess potential heterogeneity pleiotropy. What's more, replication reverse analyses were performed verify reliability results order disease. Furthermore, conducted a pathway identify pathways. 59 27 metabolite nominally associated with (P < 0.05) A total four known metabolites, namely beta-hydroxyisovaleroylcarnitine (OR 1.06, 95% CI 1.027–1.094, FDR 0.07), 1-palmitoyl-2-arachidonoyl 1.07, 1.029–1.110, 0.09), 1-stearoyl-2- docosahexaenoyl 1.034–1.113, 0.07) Linoleoyl-arachidonoyl-glycerol, 1.036–1.105, 0.05), two ratios, spermidine N-acetylputrescine ratio 0.94, 0.903–0.972, 0.09) benzoate linoleoyl-arachidonoyl-glycerol 0.87, 0.879–0.962, confirmed having significant after correcting for method (p 0. 1). was found be established beta -hydroxyisovalerylcarnitine validation in other datasets. Moreover, multiple pathways discovered Our supports hypothesis that have an impact on demonstrating important new strategies

Язык: Английский

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Investigating the shared genetic basis of inflammatory bowel disease and systemic lupus erythematosus using genetic overlap analysis

BMC Genomics, Год журнала: 2024, Номер 25(1)

Опубликована: Сен. 16, 2024

Inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE) are autoimmune diseases that often coexist clinically. This phenomenon might be due to shared genetic components.

Язык: Английский

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Inhibitory neuron links the causal relationship from air pollution to psychiatric disorders: a large multi-omics analysis

Journal Of Big Data, Год журнала: 2024, Номер 11(1)

Опубликована: Сен. 11, 2024

Язык: Английский

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