How Important is the Metal-free Catalytic Knoevenagel Reaction in Medicinal Chemistry? An Updated Review DOI
Suzaimi Johari, Mohd Rafie Johan, Nader Ghaffari Khaligh

и другие.

Current Medicinal Chemistry, Год журнала: 2024, Номер 31(27), С. 4286 - 4311

Опубликована: Янв. 21, 2024

Abstract: The Knoevenagel condensation is a powerful and primary step for the development of carbon-carbon bond transformations. These condensations offer versatile products/ intermediates diverse uses in polymers, cosmetics, chemical industries, medicinal chemistry. Various homogenous heterogenous catalysts have been found to promote reaction, both environmentally economically. Due their attractive use production pharmaceutical drugs, they are proven be main force that drives synthesis involving numerous multi-component multistep reactions. present study, therefore, aims summarise reported reactions using metal-free resulting pharmaceutically useful compounds with anti-cancer, anti-tumor, anti-oxidant, anti-malarial, anti-diabetic, anti- bacterial activities. By considering factors like structure-activity relationships (SARs), reaction conditions, steps involved, as well advantages limitations particular approach, we also provide general framework direction order achieve superior characteristics catalyst.

Язык: Английский

How Important is the Metal-free Catalytic Knoevenagel Reaction in Medicinal Chemistry? An Updated Review DOI
Suzaimi Johari, Mohd Rafie Johan, Nader Ghaffari Khaligh

и другие.

Current Medicinal Chemistry, Год журнала: 2024, Номер 31(27), С. 4286 - 4311

Опубликована: Янв. 21, 2024

Abstract: The Knoevenagel condensation is a powerful and primary step for the development of carbon-carbon bond transformations. These condensations offer versatile products/ intermediates diverse uses in polymers, cosmetics, chemical industries, medicinal chemistry. Various homogenous heterogenous catalysts have been found to promote reaction, both environmentally economically. Due their attractive use production pharmaceutical drugs, they are proven be main force that drives synthesis involving numerous multi-component multistep reactions. present study, therefore, aims summarise reported reactions using metal-free resulting pharmaceutically useful compounds with anti-cancer, anti-tumor, anti-oxidant, anti-malarial, anti-diabetic, anti- bacterial activities. By considering factors like structure-activity relationships (SARs), reaction conditions, steps involved, as well advantages limitations particular approach, we also provide general framework direction order achieve superior characteristics catalyst.

Язык: Английский

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