The Lancet, Год журнала: 2025, Номер 405(10478), С. 583 - 596
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
11Skin Barrier in Atopic Dermatitis
Journal of Investigative Dermatology, Год журнала: 2024, Номер 144(5), С. 989 - 1000.e1
Опубликована: Апрель 19, 2024
Язык: Английский
Процитировано
14An S100A8/A9 neutralizing antibody potently ameliorates contact hypersensitivity and atopic dermatitis symptoms.
Journal of Investigative Dermatology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1Deciphering epigenetic regulations in the inflammatory pathways of atopic dermatitis
Life Sciences, Год журнала: 2024, Номер 348, С. 122713 - 122713
Опубликована: Май 11, 2024
Язык: Английский
Процитировано
6Update on the pathogenesis of atopic dermatitis
Anais Brasileiros de Dermatologia, Год журнала: 2024, Номер 99(6), С. 895 - 915
Опубликована: Авг. 12, 2024
Atopic dermatitis is a chronic, recurrent, and multifactorial skin-mucosal manifestation resulting from the interaction between elements mainly associated with skin barrier deficit, homeostasis of immune response, neurological aspects, patterns reactivity to environmental antigens, which are established in genetically predisposed individuals. In addition skin, atopic diathesis involves other organs such as airways (upper lower), eyes, digestive tract, neuropsychiatric inflict additional morbidity on dermatological patient. The different phenotypes disease fundamentally depend participation each these factors, life circumstances, age groups, occupational exposure patterns, physical activity, pollution, genetic load, climatic factors. A better understanding complexity its pathogenesis allows not only therapeutic targets but also how identify preponderant that mediate activity circumstance, for selecting best treatment strategies mitigation triggering This narrative review presents an update dermatitis, especially aimed at clinical manifestations, main context available strategies.
Язык: Английский
Процитировано
5Off-Label Treatment in Inflammatory Skin Diseases—European Point of View
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2376 - 2376
Опубликована: Март 30, 2025
Off-label treatment is the use of a drug approved for marketing, outside registration in terms indication, age group, dose or route administration. Despite constant appearance new preparations on market, SmPCs guidelines current clinical problem. It believed that it based needs patients unmet by classical therapy methods. This work focuses off-label inflammatory dermatoses such as atopic dermatitis, psoriasis, acne vulgaris and rosacea. Publications this subject, available PubMed, Google Scholar Cochrane Library, were analyzed form review, taking into account mechanisms action, efficacy safety preparations. Based literature analysis, can be concluded drugs SmPC indications common situation dermatology. However, difficult to determine its exact frequency-there lack data prevalence appliances from European perspective. demonstrate varying effectiveness therapy, depending specific preparation. dermatology remains an important issue should explored further research.
Язык: Английский
Процитировано
0Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Апрель 1, 2025
Atopic dermatitis is a highly heritable and common inflammatory skin condition affecting children adults worldwide. Multi-ancestry approaches to atopic genetic association studies are poised boost power detect signal identify loci contributing risk. Here, we present multi-ancestry GWAS meta-analysis of twelve cohorts from five ancestral populations totaling 56,146 cases 602,280 controls. We report 101 genomic associated with dermatitis, including 16 that have not been previously or eczema. Fine-mapping, QTL colocalization, cell-type enrichment analyses identified genes cell types implicated in pathophysiology. Functional keratinocytes provide evidence for could play role through epidermal barrier function. Our study provides insights into the etiology by harnessing multiple functional unveil mechanisms which dermatitis-associated variants impact types. condition. authors perform carry out downstream experiments understand they identify.
Язык: Английский
Процитировано
0Difamilast Topically Ameliorates Pruritus, Dermatitis, and Barrier Dysfunction in Atopic Dermatitis Model Mice by Inhibiting Phosphodiesterase 4, Especially the 4B Subtype.
Journal of Pharmacology and Experimental Therapeutics, Год журнала: 2025, Номер unknown, С. 103582 - 103582
Опубликована: Апрель 1, 2025
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder, characterized by itchy eczema. The complex interplay among pruritus, inflammation, and barrier dysfunction contributes to the development, progression, chronicity of AD. Phosphodiesterase 4 (PDE4), an enzyme that specifically degrades cAMP, expressed in variety cell types, including immune cells, fibroblasts, keratinocytes. PDE4 involved persistence exacerbation diseases such as obstructive pulmonary disease, asthma, psoriasis, One topical inhibitors, difamilast, has been shown be effective clinical treatment However, its pharmacological effects mechanisms action are not completely understood. Therefore, we evaluated difamilast on dermatitis, MC903-induced AD model mice. results revealed single application dramatically reduced number scratching events, indicator repeated increase ear thickness, transepidermal water loss, dysfunction. In addition, these symptoms were milder PDE4B-deficient mice than wild-type mice, had little or no further therapeutic attenuating symptoms. summary, our study demonstrated effectively alleviates primary through inhibition PDE4B, one mechanisms. SIGNIFICANCE STATEMENT: This major atopic also detailed mechanism which effect mediated mainly PDE4B inhibition. may provide new insights into use for dermatitis.
Язык: Английский
Процитировано
0Extracellular Vesicles and Their Role in Skin Inflammatory Diseases: From Pathogenesis to Therapy
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3827 - 3827
Опубликована: Апрель 18, 2025
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released into the extracellular space by almost all known cell types. They facilitate communication between cells transferring bioactive molecules, which impact both physiological processes development of diseases. EVs play a crucial role in pathogenesis various diseases participating multiple pathological processes. contribute to disease progression triggering cytokine release, modulating immune activity, inducing inflammatory responses. Beyond their implications, also offer significant therapeutic potential. Both natural engineered show great potential fields targeted therapy, drug delivery, modulation dermatological applications. The EV-based treatments is showing promise advancing patient outcomes, particularly chronic immune-mediated skin conditions. This review comprehensively examined biogenesis, classification, functional roles EVs, advanced methods for isolation characterization. Furthermore, we summarized recent studies highlighting involvement four major diseases: psoriasis, atopic dermatitis, systemic lupus erythematosus, wound healing.
Язык: Английский
Процитировано
0Gut microbiota modulation: a key determinant of atopic dermatitis susceptibility in children
Frontiers in Microbiology, Год журнала: 2025, Номер 16
Опубликована: Апрель 28, 2025
Atopic dermatitis is a chronic inflammatory skin condition with higher incidence rate among children. In recent years, the role of gut microbiota in pathogenesis atopic has garnered increasing attention. This review systematically delineates research advancements structural characteristics children and its influencing factors. Studies have revealed significant differences structure between healthy controls, characterized by reduction microbial diversity, decrease beneficial bacteria, an increase harmful bacteria. Dietary patterns, environmental factors, birth antibiotic use, gestational diabetes mellitus are factors could impact hence susceptibility to dermatitis. Moreover, this explores interplay immune system dermatitis, potential inform more effective probiotic treatment strategies for
Язык: Английский
Процитировано
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