Frontiers in Microbiology, Год журнала: 2025, Номер 16
Опубликована: Апрель 28, 2025
Atopic dermatitis is a chronic inflammatory skin condition with higher incidence rate among children. In recent years, the role of gut microbiota in pathogenesis atopic has garnered increasing attention. This review systematically delineates research advancements structural characteristics children and its influencing factors. Studies have revealed significant differences structure between healthy controls, characterized by reduction microbial diversity, decrease beneficial bacteria, an increase harmful bacteria. Dietary patterns, environmental factors, birth antibiotic use, gestational diabetes mellitus are factors could impact hence susceptibility to dermatitis. Moreover, this explores interplay immune system dermatitis, potential inform more effective probiotic treatment strategies for
Язык: Английский
Процитировано
0Thymic stromal lymphopoietin-activated basophil promotes lung inflammation in mouse atopic march model
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Май 15, 2025
Atopic dermatitis (AD), a prevalent inflammatory skin disease affecting 10%-20% of the population, is linked to development asthma through atopic march (AM). This study aims explore role basophils in OVA-induced lung inflammation presence AD-like lesions and investigate potential contribution thymic stromal lymphopoietin (TSLP) activating basophils. Mouse AM models were established C57BL/6 mice using MC903 OVA epicutaneous sensitization, followed by intranasal challenges. An intraperitoneal OVA-sensitized model was employed as control group. RNA-Seq analysis conducted on CD45+ immune cells from these models. Histologic examinations, flow cytometry, ELISA used examine systemic response. Basophil depletion achieved administration anti-FcϵRIα mAb. The TSLP investigated TSLPR knockout mice. As sensitization model, also induced eosinophilic mice, resembling process. revealed differential gene expression, with genes related being prominent model. Increased basophil activation IL-4 production observed epicutaneously sensitized attenuated inflammation. levels increased topical MC903, reduced inflammation, suggesting involved activation. Basophils play crucial context lesions, appears drive Understanding interactions provides insights for therapeutic interventions AM-associated conditions.
Язык: Английский
Процитировано
0Efficacy of Upadacitinib in Treating Alopecia Areata, Atopic Dermatitis, and Th1 Comorbidities in Pediatric Patients: A Comprehensive Case Series and Literature Review
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(11), С. 3881 - 3881
Опубликована: Май 30, 2025
Alopecia areata (AA) and atopic dermatitis (AD) are complex immune-mediated conditions that frequently coexist in pediatric patients, complicating treatment approaches. Upadacitinib, a selective JAK1 inhibitor, modulates both Th1 Th2 pathways is approved for AD adolescents adults. This study presents case series of three adolescent patients with refractory AA treated upadacitinib 15 mg/day 12 months, alongside comprehensive literature review. All demonstrated rapid remission symptoms within the first month progressive hair regrowth, SALT scores significantly improving at six twelve months. No severe adverse events were reported. Notably, one patient achieved complete regrowth despite presence ophiasis, pattern typically associated poor prognosis. Our review identified only four previous cases successfully upadacitinib, highlighting novelty our findings. These cases, together experience, suggest offers safe effective therapeutic option concomitant AD, including those who failed conventional or biologic therapies such as dupilumab. Larger, controlled studies needed to confirm long-term efficacy safety. results also support potential role managing multiple Th1/Th2-mediated comorbidities populations.
Язык: Английский
Процитировано
0Multi-Ancestry Genome-Wide Association Meta-Analysis Identifies Novel Loci in Atopic Dermatitis
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июнь 19, 2024
ABSTRACT Atopic dermatitis (AD) is a highly heritable and common inflammatory skin condition affecting children adults worldwide. Multi-ancestry approaches to AD genetic association studies are poised boost power detect signal identify ancestry-specific loci contributing risk. Here, we present multi-ancestry GWAS meta-analysis of twelve cohorts from five ancestral populations totaling 56,146 cases 602,280 controls. We report 101 genomic associated with AD, including 15 that have not been previously or eczema. Fine-mapping, QTL colocalization, cell-type enrichment analyses identified genes cell types implicated in pathophysiology. Functional keratinocytes provide evidence for could play role through epidermal barrier function. Our study provides new insights into the etiology by harnessing multiple functional unveil mechanisms which AD-associated variants impact types. Disclosure Statement BRG, MO, CH, KMS employees AbbVie. FT was an employee AbbVie at time study. JEG (University Michigan) has received research support AbbVie, Janssen, Almirall, Prometheus Biosciences/Merck, BMS/Celgene, Boehringer Ingelheim, Galderma, Eli Lilly, advisor Sanofi, BMS, Ingelheim. MKS, RU, MTP, QL, RW, JMK, LCT University Michigan no funding disclose. MEM, AHS, FDM, DW, JTG, HH Children’s Hospital Philadelphia The design, conduct, financial this were provided participated interpretation data, review, approval publication.
Язык: Английский
Процитировано
1Regulatory T cells and their role in allergic disease
Allergy, Год журнала: 2024, Номер unknown
Опубликована: Сен. 27, 2024
Abstract The incidence of allergic diseases has been rising over the past decades, and this troubling trend coincides with environmental changes such as shifts in diet increased antibiotic use, both which can impact our immune system. Allergic reactions occur when system overreacts to normally harmless substances, it is known that regulatory T cells (Tregs) play a major role suppression generation tolerance. However, new research suggests Tregs malfunction environments promote allergies. This review delves into Treg function, how factors influence their ability maintain homeostasis. Specifically, we explore origins cells, well mechanisms used for inflammation tissue healing, concentration on food allergies, atopic dermatitis asthma. Understanding function context changing environment crucial developing strategies prevent treat
Язык: Английский
Процитировано
1Halting the Vicious Cycle of Atopic Dermatitis: Empowered by Scientific Understanding
Journal of Investigative Dermatology, Год журнала: 2024, Номер 144(5), С. 917 - 918
Опубликована: Апрель 19, 2024
The progress in our understanding of atopic dermatitis (AD) (atopic eczema) the last 10 years has been remarkable. Nearly half scientific papers ever published on AD have written years. This contribution knowledge, parallel with technological and pharmaceutical progress, transformed ability to treat some most severe forms AD. Notably, we seen advent biologics such as anti–IL-4 receptor biologic dupilumab (Simpson et al, 2016), 2 anti–IL-13 agents (tralokinumab [Wollenberg 2021] lebrikizumab [Silverberg 2023]), small-molecular Jak inhibitors (the Jak1 upadacitinib [Guttman-Yassky abrocitinib [Simpson 2020] Jak1/Jak2 inhibitor baricitinib [Zhou 2021]).
Язык: Английский
Процитировано
0Updated insights into the molecular pathogenesis of canine atopic dermatitis
Veterinary Dermatology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 25, 2024
Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed revolutionised our knowledge of human AD; understanding the molecular fingerprint AD associated pathogenic immune pathways led to preclinical assessments several novel treatments. Initial studies using microarray analysis analyse transcriptome (gene expression) changes provided relevant insight on structural occurring at time acute or lesions, after immunomodulating treatments drugs ciclosporin dupilumab, monoclonal antibody anti‐IL4 receptor. revealed that characterised by activation multiple cytokine (predominance T helper cell [Th]2 some Th1, Th17 Th22) as well dysregulated expression barrier components in skin. There are reports different single targets (e.g. interleukin [IL]‐13, CCL17 periostin) spontaneous canine (cAD). However, significant have been limited study analysing lesions dogs. While revealing large number genes differentially expressed cAD skin, small sample size (n = 13 dogs) lack key epidermal microarrays inhibited discussion towards specific immunological changes. This review summarises current literature regarding mechanisms cAD, including recent data RNA sequencing, compares aspects previously published from AD.
Язык: Английский
Процитировано
0IL-4 and dendritic cells in atopic dermatitis: Old dogs learn new tricks
Journal of Allergy and Clinical Immunology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0A genome-wide pleiotropy study between atopic dermatitis and neuropsychiatric disorders
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Окт. 30, 2024
Abstract Comorbidities between atopic dermatitis (AD) and neuropsychiatric disorders are frequently reported, however the extent of shared genetic architecture remains unclear. Here, we performed a large-scale genome-wide pleiotropy approach to investigate correlations causal associations AD five disorders, attention deficit hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BP), major depressive (MDD), schizophrenia (SCZ). Using association (GWAS) data, explored overlaps, pleiotropic loci assessed capacity identify drug targets. We identified significant positive ADHD (rg=0.14, P-value=2×10), MDD (rg=0.13, P-value=1.2×10 ³) BP (rg=0.11, P-value= 4×10 ³). Genome-wide scans 37 distinct traits, with gene-based analyses highlighting 86 unique genes participating in inflammatory pathways. Pleiotropy-informed target prioritization facilitated identification novel pathophysiological mechanisms for putative targets, such as members TNF JAK-STAT3 signaling. Mendelian randomization provided evidence relationship liability an increased risk AD, independent sample overlap. Collectively, our findings elucidate molecular emphasizing immune-related pathways key contributors both disease categories, potential implications therapeutic interventions targeting common mechanisms.
Язык: Английский
Процитировано
0Atualização na patogênese da dermatite atópica
Опубликована: Ноя. 1, 2024
Процитировано
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