Feasibility, acceptability, and safety of a novel device for self-collecting capillary blood samples in clinical trials in the context of the pandemic and beyond DOI Creative Commons
Harika Dasari, Anna Smyrnova, Jing Leng

и другие.

PLoS ONE, Год журнала: 2024, Номер 19(5), С. e0304155 - e0304155

Опубликована: Май 29, 2024

Background Home blood self-collection devices can enable remote monitoring, but their implementation requires validation. Our objectives were to explore (i) the impact of sampling sites and topical analgesia on capillary volume pain perception (ii) safety, acceptability, failure among adults children using Tasso-SST device. Methods We conducted a two-phase study. The investigational phase consisted two on-site cross-sectional studies in healthy adult participants (≥ 12 years) (1–17 with accompanying parent. Adults received 4 samplings, where puncture randomized factorial design, venipuncture; (and one parent) had sampling. co-primary outcomes pain. was multicentre trials choosing visits; volume, collection failure, adverse events, satisfaction documented. Results In , 90 9 7 parents enrolled; 15 2 preschoolers participated . study, device collected median (25%, 75%) 450 (250, 550) μl no significant difference between site, analgesia, its interaction. Using reduced by 0.61 (95% CI: 0.97, 0.24; P <0.01) points 11-point scale; reduction varied lower back showing most decrease. Overall, combining all phases, 425 500) μl, rate 4.4%; minor effects reported 8.9% participants, willing use again. Conclusion Capillary self-collection, yielding slightly less than 500 proves be safe relatively painless method for children, high low rates. site do not affect could reduce

Язык: Английский

Capillary blood self‐collection for high‐throughput proteomics DOI Creative Commons
Bassim El‐Sabawi, Shi Huang, Kahraman Tanrıverdi

и другие.

PROTEOMICS, Год журнала: 2024, Номер 24(16)

Опубликована: Май 24, 2024

Abstract In this study, we sought to compare protein concentrations obtained from a high‐throughput proteomics platform (Olink) on samples collected using capillary blood self‐collection (with the Tasso+ device) versus standard venipuncture (control). Blood collection was performed 20 volunteers, including one sample via and two device. were stored at 2°C–8°C for 24‐hs (Tasso‐24) or 48‐h (Tasso‐48) prior processing simulate shipping times study participant's home. Proteomics analyzed Olink (384 Inflammatory Panel). successful in 37/40 attempts. Of 230 proteins included our analysis, Pearson correlations ( r) mean coefficient of variation (CV) between Tasso‐24 Tasso‐48 variable. 34 (14.8%) had both correlation r > 0.5 CV < 0.20. 68 (29.6%) Combining analyses, 26 (11.3%) met these thresholds. We concluded that processed 24–48 h after demonstrated wide technical variability variable with gold‐standard. Use home large‐scale should be limited select good agreement venipuncture.

Язык: Английский

Процитировано

5
­­Evaluating blood sampling strategies within the SIREN study: the experience from a large cohort of healthcare workers in the UK DOI Creative Commons
Nipunadi Hettiarachchi,

Debbie Blick,

Tom Coleman

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Abstract Background Delivering research studies that require a large number of samples to monitor specific populations is complex, often resulting in high costs and intricate logistics. We aim describe the processes for blood sample collection management evaluate alternative sampling methods within cohort healthcare workers UK (the SIREN study). Methods conducted process evaluation. First, we described across different study periods from June 2020 March 2024 how these evolved over time. Secondly, compared sampling: venous phlebotomy (hospital-based) vs. capillary (at-home). Results The main challenges with stemmed scale use decentralised 135 hospital sites during COVID-19 pandemic. adapted our as progressed, overcoming most challenges. When comparing hospital-based at-home sampling, overall, return rates taken at home were higher than site- based (80% vs 71%, respectively). At-home took less time be returned UKHSA Laboratory testing (median 2 days; interquartile (IQ) 2-3) 6 IQ 3-8). However, more likely considered void (4%) when tested (0%). Cost was almost 3-times (£34.05 £11.50, respectively), however larger volumes obtained via (8 ml 600 µl whole blood). Conclusions Sample are complex. Our results support an effective cheaper strategy therefore should method future research. Trial registration number: ISRCTN11041050 - date 12/01/2021.

Язык: Английский

Процитировано

0
NEW TRENDS IN BIOANALYSIS SAMPLING AND PRETREATMENT: HOW MODERN MICROSAMPLING IS REVOLUTIONISING THE FIELD DOI Creative Commons
Michele Protti, Elisa Milandri,

Roberta Di Lecce

и другие.

Advances in Sample Preparation, Год журнала: 2025, Номер unknown, С. 100161 - 100161

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Determining the Efficacy, Feasibility, and Impact of Storage Conditions on At-Home Blood Collection Kits for Proteomic Studies DOI Creative Commons

Caroline Scranton,

Xiaoxiao Sun,

Denazir Atizol Rodriguez

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

At-home blood collection kits have the potential to greatly increase efficiency of for diagnostic or research purposes by reducing cost and burden on participants, researchers, physicians eliminating need a phlebotomist, specialized equipment, on-site processing. These shown be effective studying specific metabolites proteins, but analyses targeting entire proteome, their effectiveness is unknown. For this study, data human serum proteome was compared when capillary-collected with Tasso+ device (Tasso Inc.) versus gold-standard venous samples drawn trained phlebotomist. Analyses were conducted using SomaScan 7K assay (SomaLogic Inc.), which assesses levels nearly 7,600 proteins. Additionally, duplicate also subjected variety pre-processing storage temperatures times mimic effects shipping from participants baseline samples. Minimal differences seen between results capillary all participants. Delays in processing greater than 48 hours led large changes detected protein throughout while lower holding (refrigeration at > 4°C) decreased amount change proteome. Overall, it determined that processed immediately, gives similar blood, minimizing time ( < hrs) temperature can minimize collected at-home assay.

Язык: Английский

Процитировано

0
Feasibility, acceptability, and safety of a novel device for self-collecting capillary blood samples in clinical trials in the context of the pandemic and beyond DOI Creative Commons
Harika Dasari, Anna Smyrnova, Jing Leng

и другие.

PLoS ONE, Год журнала: 2024, Номер 19(5), С. e0304155 - e0304155

Опубликована: Май 29, 2024

Background Home blood self-collection devices can enable remote monitoring, but their implementation requires validation. Our objectives were to explore (i) the impact of sampling sites and topical analgesia on capillary volume pain perception (ii) safety, acceptability, failure among adults children using Tasso-SST device. Methods We conducted a two-phase study. The investigational phase consisted two on-site cross-sectional studies in healthy adult participants (≥ 12 years) (1–17 with accompanying parent. Adults received 4 samplings, where puncture randomized factorial design, venipuncture; (and one parent) had sampling. co-primary outcomes pain. was multicentre trials choosing visits; volume, collection failure, adverse events, satisfaction documented. Results In , 90 9 7 parents enrolled; 15 2 preschoolers participated . study, device collected median (25%, 75%) 450 (250, 550) μl no significant difference between site, analgesia, its interaction. Using reduced by 0.61 (95% CI: 0.97, 0.24; P <0.01) points 11-point scale; reduction varied lower back showing most decrease. Overall, combining all phases, 425 500) μl, rate 4.4%; minor effects reported 8.9% participants, willing use again. Conclusion Capillary self-collection, yielding slightly less than 500 proves be safe relatively painless method for children, high low rates. site do not affect could reduce

Язык: Английский

Процитировано

2