Correlation of Stress and Oral Inflammatory Burden in Patients With Chronic Periodontitis in a Sample Population From Bhopal: A Randomized Clinical Study DOI Open Access
Anuj Singh Parihar,

Sumit Narang

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

Introduction Chronic periodontitis is a prevalent inflammatory disease that leads to the destruction of tooth-supporting structures. Psychological stress potential risk factor for periodontitis, potentially exacerbating inflammation and impairing treatment outcomes. This study aims explore correlation between chronic oral burden, as measured by Periodontal Inflamed Surface Area (PISA), in sample population from Bhopal, India. Methods randomized clinical included 1,250 participants, divided into three groups: Group A (control, n=250), B (chronic n=500), C (post-treatment n=500). Participants underwent comprehensive periodontal examination, including calculation PISA, completed Perceived Stress Scale-10 (PSS-10) assess levels. Statistical analysis Pearson's relationship PSS-10 scores with comparisons among groups using variance or Kruskal-Wallis tests. Results exhibited significantly higher parameters than (p<0.001 all comparisons). showed significant improvements both following (p<0.001). positive was observed PISA (r=0.62, p<0.001), indicating perceived associated increased untreated periodontitis. persisted after adjusting confounders, age, sex, socioeconomic status. Conclusions burden patients suggesting may act an independent progression. therapy reduces alleviates psychological distress. Integrating management plans enhance patient outcomes, highlighting importance holistic approach care.

Язык: Английский

Mitophagy and Its Significance in Periodontal Disease DOI Open Access

Guliqihere Abulaiti,

Xu Qin, Lili Chen

и другие.

Oral Diseases, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Periodontal disease is a common chronic inflammatory condition affecting the tissues that support teeth, leading to their destruction. Mitophagy, specialized form of autophagy responsible for degrading damaged mitochondria, plays crucial role in maintaining cellular homeostasis. However, its periodontal progression remains poorly understood. This review aims summarize recent research on mitophagy's pathogenesis. A comprehensive literature mitophagy was conducted using PubMed, Scopus, and Web Science databases, employing keywords related such as "periodontal," "periodontitis," "gingiva," "gingivitis." 18 original studies revealed by regulating key pathophysiological mechanisms. Specifically, modulates inflammation influencing pro-inflammatory cytokines mitochondrial reactive oxygen species. Additionally, it essential alveolar bone remodeling, impacting both resorption regeneration. Mitophagy also regulates cell apoptosis within tissues, helping preserve function tissue integrity during progression. pathogenesis modulating inflammation, death tissues. Further needed explore therapeutic potential treatment improve targeted interventions.

Язык: Английский

Процитировано

0
Editorial – Immunobiophysics: Advances and techniques DOI
Luiz Eduardo Baggio Savio

Journal of Immunological Methods, Год журнала: 2024, Номер unknown, С. 113755 - 113755

Опубликована: Сен. 1, 2024

Процитировано

0
Correlation of Stress and Oral Inflammatory Burden in Patients With Chronic Periodontitis in a Sample Population From Bhopal: A Randomized Clinical Study DOI Open Access
Anuj Singh Parihar,

Sumit Narang

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

Introduction Chronic periodontitis is a prevalent inflammatory disease that leads to the destruction of tooth-supporting structures. Psychological stress potential risk factor for periodontitis, potentially exacerbating inflammation and impairing treatment outcomes. This study aims explore correlation between chronic oral burden, as measured by Periodontal Inflamed Surface Area (PISA), in sample population from Bhopal, India. Methods randomized clinical included 1,250 participants, divided into three groups: Group A (control, n=250), B (chronic n=500), C (post-treatment n=500). Participants underwent comprehensive periodontal examination, including calculation PISA, completed Perceived Stress Scale-10 (PSS-10) assess levels. Statistical analysis Pearson's relationship PSS-10 scores with comparisons among groups using variance or Kruskal-Wallis tests. Results exhibited significantly higher parameters than (p<0.001 all comparisons). showed significant improvements both following (p<0.001). positive was observed PISA (r=0.62, p<0.001), indicating perceived associated increased untreated periodontitis. persisted after adjusting confounders, age, sex, socioeconomic status. Conclusions burden patients suggesting may act an independent progression. therapy reduces alleviates psychological distress. Integrating management plans enhance patient outcomes, highlighting importance holistic approach care.

Язык: Английский

Процитировано

0