Identification of an immunological signature of long COVID syndrome
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 8, 2025
Acute
COVID-19
infection
causes
significant
alterations
in
the
innate
and
adaptive
immune
systems.
While
most
individuals
recover
naturally,
some
develop
long
COVID
(LC)
syndrome,
marked
by
persistent
or
new
symptoms
weeks
to
months
after
SARS-CoV-2
infection.
Despite
its
prevalence,
there
are
no
clinical
tests
distinguish
LC
patients
from
those
fully
recovered.
Understanding
immunological
basis
of
is
essential
for
improving
diagnostic
treatment
approaches.
We
performed
deep
immunophenotyping
functional
assays
examine
profiles
patients,
with
active
COVID-19,
recovered
healthy
donors.
This
analysis
assessed
both
features,
identifying
potential
biomarkers
syndrome.
A
Binomial
Generalized
Linear
Model
(BGLM)
was
used
pinpoint
features
characterizing
LC.
exhibited
depletion
cell
subsets,
including
plasmacytoid
conventional
dendritic
cells,
classical,
non-classical,
intermediate
monocytes,
monocyte-derived
inflammatory
cells.
Elevated
basal
inflammation
observed
compared
whose
were
closer
donors
individuals.
However,
displayed
alterations,
reduced
T
subsets
(CD4,
CD8,
Tregs)
switched
memory
B
similar
patients.
Through
BGLM,
a
unique
signature
identified,
featuring
CD8
gd
cells
low
proliferative
capacity
diminished
expression
activation
homing
receptors.
The
findings
highlight
associated
characterized
dysregulation.
recovery
comparable
Recovered
individuals,
deficits
populations
evident,
differentiating
full
recovery.
These
provide
insights
into
pathogenesis
may
support
development
tools
targeted
therapies.
Язык: Английский
An angel or a devil? Current view on the role of CD8+ T cells in the pathogenesis of myasthenia gravis
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 20, 2024
Abstract
Background
Myasthenia
gravis
(MG)
and
the
experimental
autoimmune
MG
(EAMG)
animal
model
are
characterized
by
T-cell-induced
B-cell-dominated
diseases
that
affect
neuromuscular
junction.
Several
subtypes
of
CD4
+
T
cells,
including
helper
(Th)
17
follicular
Th
regulatory
cells
(Tregs),
contribute
to
pathogenesis
MG.
However,
increasing
evidence
suggests
CD8
also
play
a
critical
role
in
treatment
Main
body
Herein,
we
review
literature
on
MG,
focusing
their
potential
effector
roles,
as
well
relevant
(peripheral,
situ,
cerebrospinal
fluid,
under
different
treatments),
T-cell
receptor
usage,
cytokine
chemokine
expression,
cell
marker
Treg,
Tc17,
CD3
CD20
T,
CXCR5
cells.
Conclusions
Further
studies
necessary
determine,
among
others,
real
pattern
Vβ
gene
usage
autoantigen-specific
patients
with
images
physiology
function
from
MG/EAMG,
subset
(Tc1,
IL-17
IFN-γ
cells).
There
many
reports
CD20-expressing
(or
T)
diseases,
especially
multiple
sclerosis
rheumatoid
arthritis.
Unfortunately,
up
now,
there
has
been
no
report
these
which
might
be
good
direction
for
future
studies.
Язык: Английский
Chemokine receptors in COVID-19 infection
International review of cell and molecular biology,
Год журнала:
2024,
Номер
unknown, С. 53 - 94
Опубликована: Янв. 1, 2024
Язык: Английский
Longitudinal analysis of memory Tfh cells and antibody response following CoronaVac vaccination
JCI Insight,
Год журнала:
2023,
Номер
8(15)
Опубликована: Июнь 29, 2023
The
inactivated
vaccine
CoronaVac
is
one
of
the
most
widely
used
COVID-19
vaccines
globally.
However,
longitudinal
evolution
immune
response
induced
by
remains
elusive
compared
with
other
platforms.
Here,
we
recruited
88
healthy
individuals
who
received
3
doses
vaccine.
We
longitudinally
evaluated
their
polyclonal
and
antigen-specific
CD4+
T
cells
neutralizing
antibody
after
receiving
each
dose
for
over
300
days.
Both
second
third
robust
spike-specific
antibodies,
a
further
increasing
overall
magnitude
neutralization
against
Omicron
sublineages
B.1.1.529,
BA.2,
BA.4/BA.5,
BA.2.75.2.
Spike-specific
circulating
follicular
helper
(cTfh)
were
markedly
increased
vaccine,
accompanied
altered
composition
functional
cTfh
cell
subsets
distinct
effector
memory
potential.
Additionally,
positively
correlated
titers.
Our
results
suggest
that
vaccine-induced
are
capable
supporting
humoral
immunity
long-term
protection.
Язык: Английский
Longitudinal evaluation of innate immune responses to three doses of CoronaVac vaccine
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 2, 2023
The
adaptive
immune
responses
induced
by
inactivated
COVID-19
vaccine
has
been
extensively
studied.
However,
few
studies
have
analyzed
the
impact
of
vaccination
on
innate
cells.
Here
in
this
study,
we
recruited
62
healthcare
workers
who
received
three
doses
CoronaVac
and
longitudinally
profiled
alterations
peripheral
monocytes
NK
cells
during
vaccination.
results
showed
that
both
monocyte
cell
subsets
distribution
were
altered,
although
frequencies
total
remained
stable
Additionally,
found
2nd
3rd
dose
elicited
robust
IFN-γ-producing
response.
Our
data
provided
necessary
insights
context
homologous
vaccination,
supplied
immunological
basis
for
future
design
vaccines
against
SARS-CoV-2
or
other
viruses.
Язык: Английский
Longitudinal analysis of memory T follicular helper cells and antibody response following CoronaVac vaccination
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Май 17, 2023
Abstract
The
inactivated
vaccine
CoronaVac
is
one
of
the
most
widely
used
COVID-19
vaccines
globally.
However,
longitudinal
evolution
immune
response
induced
by
remains
elusive
compared
to
other
platforms.
Here,
we
recruited
88
healthy
individuals
that
received
3
doses
vaccine.
We
longitudinally
evaluated
their
polyclonal
and
antigen-specific
CD4
+
T
cells
neutralizing
antibody
after
receiving
each
dose
for
over
300
days.
Both
2
nd
rd
vaccination
robust
spike-specific
antibodies,
with
a
further
increased
overall
magnitude
response,
neutralization
against
Omicron
sub-lineages
B.1.1.529,
BA.2,
BA.4/BA.5
BA.2.75.2.
Spike-specific
cell
circulating
follicular
helper
(cT
FH
)
were
markedly
vaccine,
accompanied
altered
composition
functional
cT
subsets
distinct
effector
memory
potential.
Additionally,
are
positively
correlated
titers.
Our
results
suggest
vaccine-induced
capable
supporting
humoral
immunity
long-term
protection.
Язык: Английский