Longitudinal analysis of memory T follicular helper cells and antibody response following CoronaVac vaccination DOI Creative Commons
Pengcheng Zhou,

Cheng Cao,

Tuo Ji

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Май 17, 2023

Abstract The inactivated vaccine CoronaVac is one of the most widely used COVID-19 vaccines globally. However, longitudinal evolution immune response induced by remains elusive compared to other platforms. Here, we recruited 88 healthy individuals that received 3 doses vaccine. We longitudinally evaluated their polyclonal and antigen-specific CD4 + T cells neutralizing antibody after receiving each dose for over 300 days. Both 2 nd rd vaccination robust spike-specific antibodies, with a further increased overall magnitude response, neutralization against Omicron sub-lineages B.1.1.529, BA.2, BA.4/BA.5 BA.2.75.2. Spike-specific cell circulating follicular helper (cT FH ) were markedly vaccine, accompanied altered composition functional cT subsets distinct effector memory potential. Additionally, are positively correlated titers. Our results suggest vaccine-induced capable supporting humoral immunity long-term protection.

Язык: Английский

Identification of an immunological signature of long COVID syndrome DOI Creative Commons
Gisella Guerrera, Manolo Sambucci, Eleonora Timperi

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 8, 2025

Acute COVID-19 infection causes significant alterations in the innate and adaptive immune systems. While most individuals recover naturally, some develop long COVID (LC) syndrome, marked by persistent or new symptoms weeks to months after SARS-CoV-2 infection. Despite its prevalence, there are no clinical tests distinguish LC patients from those fully recovered. Understanding immunological basis of is essential for improving diagnostic treatment approaches. We performed deep immunophenotyping functional assays examine profiles patients, with active COVID-19, recovered healthy donors. This analysis assessed both features, identifying potential biomarkers syndrome. A Binomial Generalized Linear Model (BGLM) was used pinpoint features characterizing LC. exhibited depletion cell subsets, including plasmacytoid conventional dendritic cells, classical, non-classical, intermediate monocytes, monocyte-derived inflammatory cells. Elevated basal inflammation observed compared whose were closer donors individuals. However, displayed alterations, reduced T subsets (CD4, CD8, Tregs) switched memory B similar patients. Through BGLM, a unique signature identified, featuring CD8 gd cells low proliferative capacity diminished expression activation homing receptors. The findings highlight associated characterized dysregulation. recovery comparable Recovered individuals, deficits populations evident, differentiating full recovery. These provide insights into pathogenesis may support development tools targeted therapies.

Язык: Английский

Процитировано

1
An angel or a devil? Current view on the role of CD8+ T cells in the pathogenesis of myasthenia gravis DOI Creative Commons
Yong Peng, Huan Yang, Quan Chen

и другие.

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Фев. 20, 2024

Abstract Background Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal model are characterized by T-cell-induced B-cell-dominated diseases that affect neuromuscular junction. Several subtypes of CD4 + T cells, including helper (Th) 17 follicular Th regulatory cells (Tregs), contribute to pathogenesis MG. However, increasing evidence suggests CD8 also play a critical role in treatment Main body Herein, we review literature on MG, focusing their potential effector roles, as well relevant (peripheral, situ, cerebrospinal fluid, under different treatments), T-cell receptor usage, cytokine chemokine expression, cell marker Treg, Tc17, CD3 CD20 T, CXCR5 cells. Conclusions Further studies necessary determine, among others, real pattern Vβ gene usage autoantigen-specific patients with images physiology function from MG/EAMG, subset (Tc1, IL-17 IFN-γ cells). There many reports CD20-expressing (or T) diseases, especially multiple sclerosis rheumatoid arthritis. Unfortunately, up now, there has been no report these which might be good direction for future studies.

Язык: Английский

Процитировано

5
Chemokine receptors in COVID-19 infection DOI

Claudia Gutierrez-Chavez,

Shalom Aperrigue-Lira, Brando Ortiz-Saavedra

и другие.

International review of cell and molecular biology, Год журнала: 2024, Номер unknown, С. 53 - 94

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

4
Longitudinal analysis of memory Tfh cells and antibody response following CoronaVac vaccination DOI Creative Commons
Pengcheng Zhou,

Cheng Cao,

Tuo Ji

и другие.

JCI Insight, Год журнала: 2023, Номер 8(15)

Опубликована: Июнь 29, 2023

The inactivated vaccine CoronaVac is one of the most widely used COVID-19 vaccines globally. However, longitudinal evolution immune response induced by remains elusive compared with other platforms. Here, we recruited 88 healthy individuals who received 3 doses vaccine. We longitudinally evaluated their polyclonal and antigen-specific CD4+ T cells neutralizing antibody after receiving each dose for over 300 days. Both second third robust spike-specific antibodies, a further increasing overall magnitude neutralization against Omicron sublineages B.1.1.529, BA.2, BA.4/BA.5, BA.2.75.2. Spike-specific circulating follicular helper (cTfh) were markedly increased vaccine, accompanied altered composition functional cTfh cell subsets distinct effector memory potential. Additionally, positively correlated titers. Our results suggest that vaccine-induced are capable supporting humoral immunity long-term protection.

Язык: Английский

Процитировано

6
Longitudinal evaluation of innate immune responses to three doses of CoronaVac vaccine DOI Creative Commons

Cheng Cao,

Junfeng Jiang, Min Liu

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Окт. 2, 2023

The adaptive immune responses induced by inactivated COVID-19 vaccine has been extensively studied. However, few studies have analyzed the impact of vaccination on innate cells. Here in this study, we recruited 62 healthcare workers who received three doses CoronaVac and longitudinally profiled alterations peripheral monocytes NK cells during vaccination. results showed that both monocyte cell subsets distribution were altered, although frequencies total remained stable Additionally, found 2nd 3rd dose elicited robust IFN-γ-producing response. Our data provided necessary insights context homologous vaccination, supplied immunological basis for future design vaccines against SARS-CoV-2 or other viruses.

Язык: Английский

Процитировано

2
Longitudinal analysis of memory T follicular helper cells and antibody response following CoronaVac vaccination DOI Creative Commons
Pengcheng Zhou,

Cheng Cao,

Tuo Ji

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Май 17, 2023

Abstract The inactivated vaccine CoronaVac is one of the most widely used COVID-19 vaccines globally. However, longitudinal evolution immune response induced by remains elusive compared to other platforms. Here, we recruited 88 healthy individuals that received 3 doses vaccine. We longitudinally evaluated their polyclonal and antigen-specific CD4 + T cells neutralizing antibody after receiving each dose for over 300 days. Both 2 nd rd vaccination robust spike-specific antibodies, with a further increased overall magnitude response, neutralization against Omicron sub-lineages B.1.1.529, BA.2, BA.4/BA.5 BA.2.75.2. Spike-specific cell circulating follicular helper (cT FH ) were markedly vaccine, accompanied altered composition functional cT subsets distinct effector memory potential. Additionally, are positively correlated titers. Our results suggest vaccine-induced capable supporting humoral immunity long-term protection.

Язык: Английский

Процитировано

0