Bivalent mRNA booster vaccination recalls cellular and antibody immunity against antigenically divergent SARS-CoV-2 spike antigens
npj Vaccines,
Год журнала:
2025,
Номер
10(1)
Опубликована: Апрель 18, 2025
Abstract
The
ongoing
rollout
of
SARS-CoV-2
vaccines
lags
behind
rapid
viral
evolution.
Updated
vaccine
immunogens
elicit
neutralising
antibodies
against
the
component
strain.
However,
protection
future
variants
is
unclear.
Here,
we
sought
to
understand
factors
underpinning
serological
breadth
following
bivalent
BA.1
vaccination.
Booster
vaccination
33
individuals
elicited
robust
and
durable
antibody
responses
antigens
elevated
frequencies
spike-specific
CD4
CD8
T
cells.
Immunisation
predominantly
drove
recall
cross-reactive
memory
B
cells
which
also
recognised
XBB.1.5
spike,
with
significantly
enhanced
neutralisation
titres
XBB
virus
seen
within
91%
participants.
Multivariate
regression
indicated
that
both
baseline
cell
were
strong
predictors
ancestral,
post-immunisation.
These
data
highlight
updated
maintains
recognition
antigenically
evolved
suggests
help
prior
underpin
vaccine-induced
activity.
Язык: Английский
Effect of XBB.1.5-adapted booster vaccination on the imprinting of SARS-CoV-2 immunity
npj Vaccines,
Год журнала:
2024,
Номер
9(1)
Опубликована: Ноя. 21, 2024
Abstract
In
the
present
study,
Pušnik
et
al.
investigated
whether
XBB.1.5-adapted
booster
can
overcome
persistent
imprinting
of
SARS-CoV-2
immunity
by
wild-type
based
vaccines.
The
findings
demonstrate
increased
plasma
neutralization
against
homologous
variant
following
vaccination.
Formation
de
novo
humoral
response
mutated
epitopes
XBB.1.5
variant’s
surface
proteins
was
observed
in
3/20
individuals.
vaccination
had
no
significant
effect
on
T-cell
response.
Язык: Английский