Mechanisms of Copper-Induced Autophagy and Links with Human Diseases

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 99 - 99

Опубликована: Янв. 15, 2025

As a structural and catalytic cofactor, copper is involved in many biological pathways required for the biochemistry of all living organisms. However, excess intracellular can induce cell death due to its potential catalyze generation reactive oxygen species, thus homeostasis strictly regulated. And deficiency or accumulation connected with various pathological conditions. Since success platinum-based compounds clinical treatment types neoplasias, metal-based drugs have shown encouraging perspectives drug development. Compared platinum, an essential trace element that may better prospects development than platinum. Recently, therapeutic role copper-induced autophagy chronic diseases such as Parkinson’s, Wilson’s, cardiovascular disease has already been demonstrated. In brief, ions, numerous complexes, copper-based nano-preparations could autophagy, lysosome-dependent process plays important human diseases. this review, we not only focus on current advances elucidating mechanisms compounds/preparations regulation but also outline association between

Язык: Английский

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Azido acetylated-glucosamine Schiff base copper complexes accumulate in cancer cells and induce apoptosis in vitro:High selective cytotoxicity against HepG-2 cells

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142348 - 142348

Опубликована: Апрель 1, 2025

Язык: Английский

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The Induction of G2/M Phase Cell Cycle Arrest and Apoptosis by the Chalcone Derivative 1C in Sensitive and Resistant Ovarian Cancer Cells Is Associated with ROS Generation

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7541 - 7541

Опубликована: Июль 9, 2024

Ovarian cancer ranks among the most severe forms of affecting female reproductive organs, posing a significant clinical challenge primarily due to development resistance conventional therapies. This study investigated effects chalcone derivative 1C on sensitive (A2780) and cisplatin-resistant (A2780cis) ovarian cell lines. Our findings revealed that suppressed viability, induced cycle arrest at G2/M phase, triggered apoptosis in both These are closely associated with generating reactive oxygen species (ROS). Mechanistically, DNA damage, modulated activity p21, PCNA, phosphorylation Rb Bad proteins, as well cleaved PARP. Moreover, it Akt, Erk1/2, NF-κB signaling pathways. Interestingly, we observed differential Nrf2 levels between resistant cells. While increased cells after 12 h decreased them 48 h, opposite effect was Notably, these were by potent antioxidant N-acetylcysteine (NAC), underscoring crucial role ROS 1C-induced antiproliferative activity. suggest modulation can, least partially, contribute 1C.

Язык: Английский

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Synthesis of N-alkyl azoles carrying metal complexes for catalytic and medicinal applications

Inorganic Chemistry Communications, Год журнала: 2024, Номер unknown, С. 113144 - 113144

Опубликована: Сен. 1, 2024

Язык: Английский

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Phenanthroline and phenyl carboxylate mixed ligand copper complexes in developing drugs to treat cancer

Journal of Inorganic Biochemistry, Год журнала: 2024, Номер 260, С. 112700 - 112700

Опубликована: Авг. 14, 2024

Язык: Английский

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