Dengue-mediated changes in the vectorial capacity of Aedes aegypti (Diptera: Culicidae): manipulation of transmission or infection by-product? DOI Creative Commons

Ioana Mateescu,

Sébastian Lequime

Journal of Medical Entomology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

Abstract An arthropod’s vectorial capacity summarizes its disease transmission potential. Life-history traits, such as fecundity or survival, and behavioral locomotor activity, host-seeking feeding behavior, are important components of capacity. Studies have shown that mosquito-borne pathogens may alter traits their mosquito vectors, thus directly impacting epidemic Here, we compile discuss the evidence supporting dengue-mediated changes in yellow fever Aedes aegypti (L.), primary vector, evaluate whether observed effects represent an evolved trait manipulation with epidemiological implications. Dengue infection appears to manipulate essential facilitate vector–host contact, host-seeking, but underlying mechanisms still not understood. Conversely, life-history relevant vector population dynamics, oviposition, fecundity, appear be negatively impacted by dengue virus. Overall, any detrimental on a negligible cost derived from virulence has manipulating Ae. behavior performance. However, methodological disparities among studies render comparisons difficult limit ability reach well-supported conclusions. This highlights need for more standardized methods research into virus-mediated traits. Eventually, argue outlined here must considered when assessing impact other arbovirus–vector–host interactions.

Язык: Английский

Prolonged exposure to heat enhances mosquito tolerance to viral infection DOI Creative Commons
Hugo D. Perdomo, Ayda Khorramnejad,

Nfamara M. Cham

и другие.

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Фев. 4, 2025

How and to what extent mosquito-virus interaction is influenced by climate change a complex question of ecological epidemiological relevance. We worked at the intersection between thermal biology vector immunology studied shifts in tolerance resistance cell fusing agent virus (CFAV), prominent component mosquito virome known contribute shaping competence, warm-acclimated warm-evolved Aedes albopictus mosquitoes. show that length challenge influences outcome infection with mosquitoes being more tolerant CFAV infection, while resistant suffering from extensive fitness costs. These results highlight importance considering fluctuations immunity relation understand natural variation response viruses frame realistic transmission models. Single versus multi-generational exposure increased temperature alters immune viral implications for interactions under global change.

Язык: Английский

Процитировано

0
A Laboratory-Adapted and a Clinical Isolate of Dengue Virus Serotype 4 Differently Impact Aedes aegypti Life-History Traits Relevant to Vectorial Capacity DOI Creative Commons

Mariana Maraschin,

Diego Novak,

Valdorion José Klein

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 7, 2024

Dengue virus cases are on the rise globally, and strategies to reduce new infections by controlling its primary vector, mosquito Aedes aegypti, represent a promising biotechnological approach. However, interaction between serotypes genotypes with aegypti is poorly characterized at molecular level, as well in terms of life-history traits related vector capacity disease tolerance. Here, we infected two philogenetically distant strains serotype 4 genotype II: laboratory-adapted strain, DENV4 - TVP/360, recent clinical strain isolated from southern Brazil, LRV 13/422. These strains, which exhibit 26 amino acid differences their sequences, have been shown produce distinct immune phenotypes vertebrate cells. assessed various including mortality, fecundity, fertility, induced flight capacity, competence-related parameters such infection intensity prevalence, following exposure different viral concentrations. We found that each differentially affected traits. While neither significantly reduced lifespan, prevalence was influenced initial dose TVP/360. This also enhanced induced-flight early (24 hours post-infection DPI) late (21 time points. On other hand, isolate, 13/422, specifically fertility. A better understanding how arbovirus influence connected spread will be critical public health efforts mitigate outbreaks focused vector.

Язык: Английский

Процитировано

0
Prolonged thermal stress enhances mosquito tolerance to viral infection DOI Creative Commons
Hugo D. Perdomo, Ayda Khorramnejad,

Nfamara M. Cham

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Summary How and to what extent mosquito-virus interaction is influenced by climate change a complex question of ecological epidemiological relevance. We worked at the intersection between thermal biology vector immunology studied shifts in tolerance resistance cell fusing agent virus (CFAV), prominent component mosquito virome know contribute shaping competence, warm-acclimated warm-evolved Aedes albopictus mosquitoes. show that length challenge influences outcome infection with mosquitoes being more tolerant CFAV infection, while resistant suffering from extensive fitness costs. These results highlight importance considering fluctuations immunity relation understand natural variation response viruses frame realistic transmission models.

Язык: Английский

Процитировано

0
Dengue-mediated changes in the vectorial capacity of Aedes aegypti (Diptera: Culicidae): manipulation of transmission or infection by-product? DOI Creative Commons

Ioana Mateescu,

Sébastian Lequime

Journal of Medical Entomology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

Abstract An arthropod’s vectorial capacity summarizes its disease transmission potential. Life-history traits, such as fecundity or survival, and behavioral locomotor activity, host-seeking feeding behavior, are important components of capacity. Studies have shown that mosquito-borne pathogens may alter traits their mosquito vectors, thus directly impacting epidemic Here, we compile discuss the evidence supporting dengue-mediated changes in yellow fever Aedes aegypti (L.), primary vector, evaluate whether observed effects represent an evolved trait manipulation with epidemiological implications. Dengue infection appears to manipulate essential facilitate vector–host contact, host-seeking, but underlying mechanisms still not understood. Conversely, life-history relevant vector population dynamics, oviposition, fecundity, appear be negatively impacted by dengue virus. Overall, any detrimental on a negligible cost derived from virulence has manipulating Ae. behavior performance. However, methodological disparities among studies render comparisons difficult limit ability reach well-supported conclusions. This highlights need for more standardized methods research into virus-mediated traits. Eventually, argue outlined here must considered when assessing impact other arbovirus–vector–host interactions.

Язык: Английский

Процитировано

0