Prolonged exposure to heat enhances mosquito tolerance to viral infection
Communications Biology,
Год журнала:
2025,
Номер
8(1)
Опубликована: Фев. 4, 2025
How
and
to
what
extent
mosquito-virus
interaction
is
influenced
by
climate
change
a
complex
question
of
ecological
epidemiological
relevance.
We
worked
at
the
intersection
between
thermal
biology
vector
immunology
studied
shifts
in
tolerance
resistance
cell
fusing
agent
virus
(CFAV),
prominent
component
mosquito
virome
known
contribute
shaping
competence,
warm-acclimated
warm-evolved
Aedes
albopictus
mosquitoes.
show
that
length
challenge
influences
outcome
infection
with
mosquitoes
being
more
tolerant
CFAV
infection,
while
resistant
suffering
from
extensive
fitness
costs.
These
results
highlight
importance
considering
fluctuations
immunity
relation
understand
natural
variation
response
viruses
frame
realistic
transmission
models.
Single
versus
multi-generational
exposure
increased
temperature
alters
immune
viral
implications
for
interactions
under
global
change.
Язык: Английский
A Laboratory-Adapted and a Clinical Isolate of Dengue Virus Serotype 4 Differently Impact Aedes aegypti Life-History Traits Relevant to Vectorial Capacity
Mariana Maraschin,
Diego Novak,
Valdorion José Klein
и другие.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 7, 2024
Dengue
virus
cases
are
on
the
rise
globally,
and
strategies
to
reduce
new
infections
by
controlling
its
primary
vector,
mosquito
Aedes
aegypti,
represent
a
promising
biotechnological
approach.
However,
interaction
between
serotypes
genotypes
with
aegypti
is
poorly
characterized
at
molecular
level,
as
well
in
terms
of
life-history
traits
related
vector
capacity
disease
tolerance.
Here,
we
infected
two
philogenetically
distant
strains
serotype
4
genotype
II:
laboratory-adapted
strain,
DENV4
-
TVP/360,
recent
clinical
strain
isolated
from
southern
Brazil,
LRV
13/422.
These
strains,
which
exhibit
26
amino
acid
differences
their
sequences,
have
been
shown
produce
distinct
immune
phenotypes
vertebrate
cells.
assessed
various
including
mortality,
fecundity,
fertility,
induced
flight
capacity,
competence-related
parameters
such
infection
intensity
prevalence,
following
exposure
different
viral
concentrations.
We
found
that
each
differentially
affected
traits.
While
neither
significantly
reduced
lifespan,
prevalence
was
influenced
initial
dose
TVP/360.
This
also
enhanced
induced-flight
early
(24
hours
post-infection
DPI)
late
(21
time
points.
On
other
hand,
isolate,
13/422,
specifically
fertility.
A
better
understanding
how
arbovirus
influence
connected
spread
will
be
critical
public
health
efforts
mitigate
outbreaks
focused
vector.
Язык: Английский
Prolonged thermal stress enhances mosquito tolerance to viral infection
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 9, 2024
Summary
How
and
to
what
extent
mosquito-virus
interaction
is
influenced
by
climate
change
a
complex
question
of
ecological
epidemiological
relevance.
We
worked
at
the
intersection
between
thermal
biology
vector
immunology
studied
shifts
in
tolerance
resistance
cell
fusing
agent
virus
(CFAV),
prominent
component
mosquito
virome
know
contribute
shaping
competence,
warm-acclimated
warm-evolved
Aedes
albopictus
mosquitoes.
show
that
length
challenge
influences
outcome
infection
with
mosquitoes
being
more
tolerant
CFAV
infection,
while
resistant
suffering
from
extensive
fitness
costs.
These
results
highlight
importance
considering
fluctuations
immunity
relation
understand
natural
variation
response
viruses
frame
realistic
transmission
models.
Язык: Английский
Dengue-mediated changes in the vectorial capacity of Aedes aegypti (Diptera: Culicidae): manipulation of transmission or infection by-product?
Journal of Medical Entomology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 22, 2024
Abstract
An
arthropod’s
vectorial
capacity
summarizes
its
disease
transmission
potential.
Life-history
traits,
such
as
fecundity
or
survival,
and
behavioral
locomotor
activity,
host-seeking
feeding
behavior,
are
important
components
of
capacity.
Studies
have
shown
that
mosquito-borne
pathogens
may
alter
traits
their
mosquito
vectors,
thus
directly
impacting
epidemic
Here,
we
compile
discuss
the
evidence
supporting
dengue-mediated
changes
in
yellow
fever
Aedes
aegypti
(L.),
primary
vector,
evaluate
whether
observed
effects
represent
an
evolved
trait
manipulation
with
epidemiological
implications.
Dengue
infection
appears
to
manipulate
essential
facilitate
vector–host
contact,
host-seeking,
but
underlying
mechanisms
still
not
understood.
Conversely,
life-history
relevant
vector
population
dynamics,
oviposition,
fecundity,
appear
be
negatively
impacted
by
dengue
virus.
Overall,
any
detrimental
on
a
negligible
cost
derived
from
virulence
has
manipulating
Ae.
behavior
performance.
However,
methodological
disparities
among
studies
render
comparisons
difficult
limit
ability
reach
well-supported
conclusions.
This
highlights
need
for
more
standardized
methods
research
into
virus-mediated
traits.
Eventually,
argue
outlined
here
must
considered
when
assessing
impact
other
arbovirus–vector–host
interactions.
Язык: Английский