Bioinspired Synthesis of Gold Nanoparticles for Enhanced Anti-Cancer Activity and Cell Viability Studies DOI Creative Commons

Bh. Prashanthi,

Rajat Singh,

Himanshu Makhija

и другие.

E3S Web of Conferences, Год журнала: 2024, Номер 588, С. 02006 - 02006

Опубликована: Янв. 1, 2024

Gold nanoparticles, or AuNPs, have garnered significant attention in biomedical research, especially cancer therapy, due to their unique physicochemical properties. This work discusses the bioinspired production of gold nanoparticles (AuNPs) using plant extracts as reducing and stabilizing agents. research conducted synthesis. Transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS), Fourier transform infrared (FTIR) were used analyze synthesized nanoparticles. These approaches characterize nanoparticles’ dimensions, morphology, stability, functional groups. At a wavelength 532 nm, averaging 18 ± 3 nm size, exhibited pronounced surface plasmon resonance (SPR) peak, indicating efficacy manufacturing method. Cell viability assessments performed HeLa (a cervical cell type), MCF-7 breast model), WI-38 healthy fibroblast model) demonstrated concentration-dependent reduction viability, with little impact on cells. concentration 100 µg/mL cells decreased 35.2% 41.7%, respectively. The was maintained at 83.4%. analysis apoptosis revealed that AuNPs induced early late rates 35.4% 45.8%, respectively, but cells, they 32.5% 42.1%. therapeutic significantly enhanced by bioactive compounds isolated from plant. eco-friendly synthesis method this study not only provides sustainable means for nanoparticle also enhances potential application anti-cancer therapies. applications these will be further explored via vivo tests, which emphasis next research.

Язык: Английский

Exploring How Microbial Extracellular Metabolites Drive Nanoparticle Synthesis: A Bioinformatics Approach DOI
Muhammad Irfan, Amrita Kumar Sana, Alishba Maryam

и другие.

BioNanoScience, Год журнала: 2025, Номер 15(2)

Опубликована: Апрель 9, 2025

Язык: Английский

Процитировано

0
Bioinspired Synthesis of Gold Nanoparticles for Enhanced Anti-Cancer Activity and Cell Viability Studies DOI Creative Commons

Bh. Prashanthi,

Rajat Singh,

Himanshu Makhija

и другие.

E3S Web of Conferences, Год журнала: 2024, Номер 588, С. 02006 - 02006

Опубликована: Янв. 1, 2024

Gold nanoparticles, or AuNPs, have garnered significant attention in biomedical research, especially cancer therapy, due to their unique physicochemical properties. This work discusses the bioinspired production of gold nanoparticles (AuNPs) using plant extracts as reducing and stabilizing agents. research conducted synthesis. Transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS), Fourier transform infrared (FTIR) were used analyze synthesized nanoparticles. These approaches characterize nanoparticles’ dimensions, morphology, stability, functional groups. At a wavelength 532 nm, averaging 18 ± 3 nm size, exhibited pronounced surface plasmon resonance (SPR) peak, indicating efficacy manufacturing method. Cell viability assessments performed HeLa (a cervical cell type), MCF-7 breast model), WI-38 healthy fibroblast model) demonstrated concentration-dependent reduction viability, with little impact on cells. concentration 100 µg/mL cells decreased 35.2% 41.7%, respectively. The was maintained at 83.4%. analysis apoptosis revealed that AuNPs induced early late rates 35.4% 45.8%, respectively, but cells, they 32.5% 42.1%. therapeutic significantly enhanced by bioactive compounds isolated from plant. eco-friendly synthesis method this study not only provides sustainable means for nanoparticle also enhances potential application anti-cancer therapies. applications these will be further explored via vivo tests, which emphasis next research.

Язык: Английский

Процитировано

0