Click chemistry-based modified exosomes: Towards enhancing precision in cancer theranostics
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160915 - 160915
Опубликована: Фев. 1, 2025
Язык: Английский
Unlocking the therapeutic potential: odyssey of induced pluripotent stem cells (iPSC) in precision cell therapies
International Journal of Surgery,
Год журнала:
2024,
Номер
110(10), С. 6432 - 6455
Опубликована: Июль 4, 2024
This
review
explores
the
application
of
induced
pluripotent
stem
cells
(iPSCs)
in
regenerative
medicine.
The
therapeutic
significance
iPSC-derived
cell
therapy
within
medicine,
emphasizes
their
reprogramming
process
and
crucial
role
cellular
differentiation
while
setting
purpose
scope
for
comprehensive
exploration
therapy.
subsequent
sections
intricately
examine
therapy,
unravelling
diverse
derivatives
iPSCs
striking
a
delicate
balance
between
advantages
limitations
applications.
Mechanisms
action,
revealing
how
seamlessly
integrate
into
tissues,
induce
regeneration,
contribute
to
disease
modeling
drug
screening
advancements
is
discussed.
analysis
extends
clinical
trials,
shedding
light
on
outcomes,
safety
considerations,
ethical
dimensions.
Challenges
concerns,
including
risk
tumorigenesis
scalability
issues,
are
explored.
focus
disease-specific
applications,
showcasing
as
promising
avenue
various
medical
conditions,
supported
by
illustrative
case
studies.
Future
directions
research
needs
outlined,
identifying
areas
further
exploration,
considerations
potential
enhancements
that
will
shape
future
landscape
therapies.
In
conclusion,
this
provides
significant
understanding
therapy's
status,
contemplates
implications
medicine
personalized
treatment
using
iPSCs,
offering
perspective
evolving
field
confines
dynamic
scientific
frontier.
Язык: Английский
Exosomes: intriguing mediators of intercellular communication in the organism’s response to noxious agents
Archives of Industrial Hygiene and Toxicology,
Год журнала:
2024,
Номер
75(4), С. 228 - 239
Опубликована: Дек. 1, 2024
Exosomes
are
small
extracellular
vesicles
that
range
from
30
to
150
nm
in
size
and
formed
through
cellular
endocytosis.
They
consist
of
proteins,
lipids,
nucleic
acids
at
varying
ratios
quantities.
The
composition
spatiotemporal
dynamics
exosomes
suggest
they
play
a
crucial
role
intercellular
communication.
information
conveyed
by
significantly
impacts
the
regulation
health
disease
states
organism.
term
"noxious"
refers
all
harmful
environmental
agents
conditions
can
disrupt
physiological
equilibrium
induce
pathological
states,
regardless
whether
radiological,
biological,
or
chemical
origin.
This
review
comprehensively
examines
presence
such
noxious
within
organism
relation
exosome
formation
function.
Furthermore,
it
explores
cause-effect
relationship
between
exosomes,
aiming
restore
homeostasis
prepare
for
defence
against
agents.
Regardless
specific
bioinformatic
content
associated
with
each
agent,
synthesis
data
on
interactions
various
types
reveals
an
organized
these
is
unachievable
without
support
exosomes.
Consequently,
identified
as
primary
communication
system
organism,
their
being
pivotal
maintaining
health-disease
balance.
Язык: Английский